Neurobehavioral assessment of rats exposed to pristine polystyrene nanoplastics upon oral exposure

Rafiee, Mohammad; Dargahi, Leila; Eslami, Akbar; Beirami, Elmira; Jahangiri‐rad, Mahsa; Sabour, Siamak; Amereh, Fatemeh

doi:10.1016/j.chemosphere.2017.11.076

Cited by 114 publications

(53 citation statements)

References 71 publications

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“…On the other hand, a study with mice fed with PS MPs did not reveal any histologically detectable lesions or significant inflammatory responses [109]. A neurobehavioral study on rat fed with NPs also did not detect any significant behavioral changes or abnormality [110].…”

Section: Toxicity Of Mps/nps In Mouse Modelsmentioning

confidence: 88%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

552

280

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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Section: Toxicity Of Mps/nps In Mouse Modelsmentioning

confidence: 88%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

552

280

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“…No statistically significant behavioral effects were observed in any of the tests performed. 153 In conclusion, it has been shown by in vitro and in vivo studies that micro-as well as nanoplastic particles might be taken up into the human body and can overcome tissue barriers, thus also allowing interaction with single cells. However, real-world plastics sources (rather than commercially available perfectly spherical polystyrene particles) have not yet been used; therefore, further studies applying different plastic materials with significant size and/or shape polydispersity as well as environmentally relevant concentrations need to be conducted to fill the existing knowledge gaps.…”

Section: Impact Of Nanoplastics On Human Healthmentioning

confidence: 95%

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Lehner

Weder

Petri‐Fink

et al. 2019

Environ. Sci. Technol.

889

364

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On account of environmental concerns, the fate and adverse effects of plastics have attracted considerable interest in the past few years. Recent studies have indicated the potential for fragmentation of plastic materials into nanoparticles, i.e., "nanoplastics," and their possible accumulation in the environment. Nanoparticles can show markedly different chemical and physical properties than their bulk material form. Therefore possible risks and hazards to the environment need to be considered and addressed. However, the fate and effect of nanoplastics in the (aquatic) environment has so far been little explored. In this review, we aim to provide an overview of the literature on this emerging topic, with an emphasis on the reported impacts of nanoplastics on human health, including the challenges involved in detecting plastics in a biological environment. We first discuss the possible sources of nanoplastics and their fates and effects in the environment and then describe the possible entry routes of these particles into the human body, as well as their uptake mechanisms at the cellular level. Since the potential risks of environmental nanoplastics to humans have not yet been extensively studied, we focus on studies demonstrating cell responses induced by polystyrene nanoparticles. In particular, the influence of particle size and surface chemistry are discussed, in order to understand the possible risks of nanoplastics for humans and provide recommendations for future studies.

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“…organism, population). Nonetheless, the rst evaluation of polystyrene NPs toxicity on the same subject demonstrated subtle and transient behavioral consequences in adult rats [26], denoting that neurotransmission might not be directly connected to the barely perceptible behavioral disorders. In support of our ndings, Wei Lin et al [73] observed declined AChE activity in Daphnia magna following exposure to various functionalized PS-NPs (PS-p-NH 2 , PS-n-NH 2 and PS-COOH).…”

Section: Discussionmentioning

confidence: 99%

“…Adult male Wistar rats were used as a model species to investigate the implications on human health and body, because they are known as the chief model in numerous elds, such as neurobehavioral and toxicological studies [23]. This paper is one of a series of papers [24,25,26] describing a comprehensive study on the potential mechanisms of toxicity and hence therein possible effects of nano(micro)plastics uptake on human health. The results obtained provide detailed information on the potential health risks of microscopic plastic particulates exposure to mammals including human.…”

Section: Introductionmentioning

confidence: 99%

Physiological stress response of the Wistar albino rats orally exposed to polystyrene nanoparticles

Babaei

Rafiee

Khodagholi

et al. 2020

Preprint

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Background Few studies have examined nano-sized plastic particulates (NPs) exposure in relation to oxidative stress and biochemical responses in rodents, commonly used for toxicity evaluations on which to base risk assessment for humans.Methods Here we explored possible oxidative stress and biochemical responses of five weeks oral exposure to polystyrene (PS) nanoparticles (1, 3, 6 and 10 mg/kg body weight per day) in male rats. We used variance analysis and variance explained statistic eta-squared (𝜂2) to estimate the strength of relationships worked out. The whole body scanning further provided insight into the bio-distribution of nanoplastics upon oral exposure.Results Results demonstrated the accumulation of PS-NPs through whole body and also a dose-dependent increase in the production of reactive oxygen species (ROS). Significant alterations in antioxidant responses including serum levels of catalase, superoxide dismutase (SOD), and total glutathione content were noticed, pointing towards a perturbation of redox state induced by the exposure conditions. Acetylcholinesterase level in highest dose group was about 40 percent lower than those in control group. Biochemical parameters viz. glucose, cortisol, lipase, lactate, lactate dehydrogenase (LDH), alkaline phosphatase, gamma-glutamyl transpeptidase (GGT), triglycerides, and urea showed a significant increase, while total protein, albumin and globulin levels showed an appreciable decline.Conclusion The pattern of associations noticed with AChE activity and biochemical responses in our study suggests the possibility that a neurobehavioral effect or dysfunctions in energy metabolism, or both, may be the potential mode of action, possibly through stress response as well as liver function. Perturbations of creatinine and uric acid levels are indeed plausible biological explanations for the association with kidney dysfunction. Although we provided a new scientific clue for exploring the biological effects of plastics nanoparticles, the results warrant additional research with a larger sample size. The suggested potential mechanisms also remains to be investigated.

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Neurobehavioral assessment of rats exposed to pristine polystyrene nanoplastics upon oral exposure

Cited by 114 publications

References 71 publications

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Physiological stress response of the Wistar albino rats orally exposed to polystyrene nanoparticles

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