Neurobehavioral Responses of Newborn Infants after Maternal Epidural Anesthesia

Scanlon, John W.; Brown, Walter U.; Weiß, Joseph; Alper, Milton H.

doi:10.1097/00000542-197402000-00005

Cited by 260 publications

(72 citation statements)

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“…However, together with analgesia, there was an increase in CO 2 arterial blood partial pressure, clearly mediated by opioid distribution in brain receptors. Furthermore, sufentanil plasmatic concentrations after injection were higher than the minimum needed for eliminating postoperative pain in patients when sufentanil was intravenously administered by a Patient Controlled Analgesia pump 22 . Plasmatic distribution of sufentanil after subarachnoid administration has been confirmed, explaining the association between respiratory depression and analgesia which can also be mediated by brain and spinal receptors.…”

Section: Discussionmentioning

confidence: 96%

“…Neonates with higher Apgar scores may display mildly depressed neurological signs due to drugs like mild hypotonia or poor primary reflex responses, etc. 22 NACS was developed to differentiate newborn drug-induced depression as a result of asphyxia, labor trauma, or neurological disease. 12 In a review article, Brockhurst et al 23 criticized the AmielTison test as follows: 1) variability of maternal anthropometric data, 2) exclusion/inclusion factors for neonates, and 3) gestational age.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects on mother and fetus of epidural and combined spinal-epidural techniques for labor analgesia

Nakamura¹,

Ganem²,

Rugolo³

et al. 2009

Rev. Assoc. Med. Bras.

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Summary objectIve. Epidural (EA) and combined spinal-epidural (CSE) techniques have both been utilized for labor analgesia. This study compared the effects on the mother and newborn of these techniques in labor analgesia and anesthesia. Methods. Forty pregnant women received epidural analgesia with 15 mL of 0.125% ropivacaine (EA group) and 5 µg of sufentanil plus 2.5mg bupivacaine in the subarachnoid space (CSE group). Pain intensity, sensory blockade level, latency time, motor block intensity, labor analgesia duration, epidural analgesia duration, maternal hypotension, and pruritus were evaluated. The newborns were evaluated by Apgar and the neurological and adaptive capacity score (NACS) developed by Amiel-Tison. results. There were no significant statistical differences between groups for pain scores, latency time, sensory blockade level, and Apgar score. Motor block, labor analgesia duration, and epidural analgesia duration were greater in the CSE group, whose seven mothers had mild pruritus. The NACS were greater in the EA group after half, two, and 24 hours. Ninety five percent of EA group newborns and 60% of CSE group newborns were found to be neurologically healthy at the 24 hour examination. conclusIon. EA and CSE analgesia relieved maternal pain during obstetric analgesia, but CSE mothers had pruritus and a longer labor. Newborns of mothers who received epidural analgesia showed the best NACS.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Effects on mother and fetus of epidural and combined spinal-epidural techniques for labor analgesia

Nakamura¹,

Ganem²,

Rugolo³

et al. 2009

Rev. Assoc. Med. Bras.

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show abstract

“…Lidocaine has been vindicated in several studies which have examined the effects of this drug on the newborn, i,z In 1974-76, neurobehavioural testing of normal newborns suggested that lidocaine used for epidural analgesia produced "floppy" babies. 3 Recently a larger series 4 using a different and more thorough neonatal assessment, showed convincingly that the previous findings with lidocaine were not clinically significant and that lidocaine was still an extremely useful agent in obstetrics.…”

Section: Local Anaestheticsmentioning

confidence: 95%

Update on obstetrical anaesthesia

Biehl

Palahniuk

1986

Can Anaesth Soc J

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“…When new experiments were made with different neurobehavioral and attitudinal tests (SCANLON test) and different Stimuli [8,15,17], remarkable differences were always noticed between groups of babies exposed to meperidine and not exposed ones. After the result of the previous researches we thought it useful to verify the effects of the association of meperidine and promethazine on the Curriculum vitae MAURO behavior of the newborn in order to estimate the actual possibility of using such method.…”

Section: Introductionmentioning

confidence: 99%