Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice

Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

“…In general, CUR is a well-known oxygen free radical scavenger (Pan et al, 2008[21]). Sun et al (2013[25]) disclosed that CUR could also recover learning and memory in senescence-accelerated mice. Similarly, our previous studies revealed that CUR could play protective roles in rat prefrontal cortical neurons in different pathological conditions (Noorafshan et al, 2015[20]).…”

Curcumin promotes exosomes/microvesicles secretion that attenuates lysosomal cholesterol traffic impairment

“…In N ‐methyl N ‐nitrosourea treated mice, curcumin administration normalized the altered levels of total lipids, cholesterol, and phospholipids in membrane preparations from cerebrum and cerebellum . Finally, beneficial effects of curcumin have been reported in different neurologic diseases such as multiple sclerosis , Alzheimer's disease , and senescence . The secretion of exosomes/microvesicles induced by curcumin shown herein, as a mechanism for the secretion of diverse materials out of the cell, may contribute to the ample variety of the potential beneficial effects of this polyphenol.…”

Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway

“…In particular, experimental evidence has demonstrated that curcumin exhibits neuroprotective effects in a variety of AD models [ 6 , 7 ]. The prevention of synaptic protein loss has been suggested to mediate the protective effects of curcumin [ 8 , 9 ]. Recently, Hoppe JB and colleagues have shown that Aβ exerted deleterious effects on synaptic activity in hippocampal slice cultures that were counteracted by curcumin via the modulation of synaptic proteins, such as CaMKII and synapsin I [ 10 ].…”