Neurobiological Pathways between Chronic Stress and Depression: Dysregulated Adaptive Mechanisms?

Sharpley, Christopher F.

doi:10.4137/cmpsy.s3658

Cited by 24 publications

(23 citation statements)

References 124 publications

(219 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was significant difference of type of psychosocial stressor between two groups. This evidence supported that psychosocial stressor influenced the developing of depression in metabolic syndrome 23 . Correlation test also showed the moderate and high correlation between SLE total score, social relationship, health and housing with BDI score.…”

Section: Introductionsupporting

confidence: 71%

“…Psychosocial stressor and chronic stress increased the activity of hypothalamuspituitary-adrenal which increased cortisol level in blood, which in long time caused the insulin resistance or metabolic syndrome through central obesity 21,22 . Hypercortisolism induced the neurobiology imbalance in amigdala and frontal cortex that manifested in emotional disorder, mood and depression 23 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Type of psychosocial stressor as risk factor of depressive symptom in metabolic syndrome

Fauziyati

Siswanto

Purnomo

et al. 2016

Bangladesh J Med Sci

View full text Add to dashboard Cite

Abstract:Metabolic syndrome and depression are two major diseases over the world, which are increasing in prevalence over time. Depression is a major mental health burden over the world. In long time, depression can lead to metabolic syndrome, while metabolic syndrome is a risk factor for developing depression. Metabolic syndrome is a major risk factor for developing cardiovascular disease. Chronic stress induced by psychosocial stressor leads to the development of both metabolic syndrome and depression. Further research is important to identify which type of psychosocial stressor is the risk factor for depressive symptom in patients with metabolic syndrome. The objective of this study is to identify the type of psychosocial stressor which could be the risk factor for depressive symptom. The study design was case control. The case group consisted of metabolic syndrome patients with depressive symptom, while the control group consisted of metabolic syndrome patients without depressive symptom. Metabolic syndrome was diagnosed based on International Diabetes Federation (IDF) criteria. Depressive symptom was measured by Beck Depression Inventory (BDI). Psychosocial stressors were measured by Stressful Life Events (SLE) questionnaire. Dependent variable was depressive symptom, while independent variables were type of psychosocial stressors (finance, work, social relationship, health and housing). Analysis methods that used in this study were independent t test, Pearson/ Spearman correlation analysis, chi square and logistic regression. There were 54 patients in this study, consisted of 24 in case group and 30 in control group. There was no significant difference in most basic characteristics between two groups. There was significant difference of SLE score between two groups. Chi square analysis showed that housing, finance, health, social relationship, and work stressors were risk factors for developing depressive symptom in metabolic syndrome (OR 24.5 (p 0.001); 9.7 (p 0.039); 8.4 (p 0.016); 5.4 (p 0.004); 3.9 (p 0.001), respectively). Demographic factor which also influenced depressive symptom was salary less than 1 million per month (OR 45, p 0.004). According to logistic regression analysis, psychosocial stressors which most influenced the depressive symptom were finance and housing. In conclusion, this study showed that housing, finance, health, social relationship and work stressors were risk factors for developing depressive symptom in metabolic syndrome.

show abstract

Section: Introductionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Type of psychosocial stressor as risk factor of depressive symptom in metabolic syndrome

Fauziyati

Siswanto

Purnomo

et al. 2016

Bangladesh J Med Sci

View full text Add to dashboard Cite

show abstract

“…These findings are of obvious value in terms of research into how these patients respond to their disease and also hold important implications for clinical practice. As is discussed below, treatments that focus upon separate aspects of the anxiety-depression construct may not always be as successful as those which encompass both sets of symptoms, thus acknowledging the overlap of these two disorders and accepting that they may have common underlying genetic and biological causes and pathways (Sharpley, 2009). …”

Section: Discussionmentioning

confidence: 97%

Variability in Anxiety and Depression Over Time Following Diagnosis in Patients with Prostate Cancer

Sharpley

Christie²,

Bitsika

2010

Journal of Psychosocial Oncology

Self Cite

View full text Add to dashboard Cite

To determine the presence and nature of variability in anxiety and depression in patients with prostate cancer (PCa) over 3 years following diagnosis, 442 patients with PCa completed standardized anxiety and depression inventories via survey between 1 and 36 months after receiving their initial diagnosis. Data were analyzed from a series of 3-month cohorts, and results indicated that total scores and incidence of clinically significant anxiety and depression varied over time, but that this variability was restricted to specific subfactors of anxiety and depression. Provision of effective psychological treatment to patients with PCa is discussed.

show abstract

“…cortisol) was observed after the stress management programme. Although both the intervention and control groups did demonstrate lowered level of salivary cortisol at the post‐assessment, it may have the implication that the programme is able to down‐regulate the effect of HPA axis among teachers with emotional disturbance (Sharpley, ). Future research using a more sophisticated and meticulously designed randomized controlled trial is needed to examine if significant results in these outcome variables may be obtained.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Evaluation on a Stress Management Programme Using a Combined Approach of Cognitive Behavioural Therapy (CBT) and Complementary and Alternative Medicine (CAM) for Elementary School Teachers

et al. 2013

View full text Add to dashboard Cite

The aim of this study is to explore the efficacy of implementing a stress management programme based on a combined approach using cognitive behavioural therapy and complementary and alternative medicine for elementary school teachers who experienced mild level of stress, anxiety and/or depressive symptoms in Hong Kong. A 12-h programme involving cognitive behavioural therapy, self-management, relaxation techniques (diaphragmatic breathing and progressive muscle relaxation), mindful exercises (qigong and yoga), aromatherapy and acupressure was conducted. A quasi-experimental design was used to compare the intervention groups (n = 47) with the wait-list control groups (n = 46). The primary outcome measures were depression, anxiety and stress. Results indicated that the intervention group had significant reduction in depression [(F = 3.93; degrees of freedom (df) = 2.90; p = 0.023)], anxiety (F = 3.37; df = 2.90; p = 0.039) and stress (F = 3.63; df = 2.89; p = 0.031) when compared with the control group. Participants in both groups demonstrated lowered level of salivary cortisol at the post-assessment. The pilot results provided preliminary support to the multi-component stress management programme in relieving affective symptoms of teachers. The programme may be considered as an initial strategy to empower teachers with the abilities to cope with their affective symptoms. Further evaluation using a better designed randomized study with a larger sample size is warranted. (word: 198; max.: 200).

show abstract

Neurobiological Pathways between Chronic Stress and Depression: Dysregulated Adaptive Mechanisms?

Cited by 24 publications

References 124 publications

Type of psychosocial stressor as risk factor of depressive symptom in metabolic syndrome

Type of psychosocial stressor as risk factor of depressive symptom in metabolic syndrome

Variability in Anxiety and Depression Over Time Following Diagnosis in Patients with Prostate Cancer

A Pilot Evaluation on a Stress Management Programme Using a Combined Approach of Cognitive Behavioural Therapy (CBT) and Complementary and Alternative Medicine (CAM) for Elementary School Teachers

Contact Info

Product

Resources

About