Neurobiology of Alcohol Craving and Relapse Prediction

Wiers, Corinde E.; Heinz, Andreas

doi:10.1002/9781118472415.ch10

Cited by 9 publications

(9 citation statements)

References 115 publications

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“…It is also common for problem drinkers to have extended periods without drinking followed by a return to previous drinking patterns 44 . Among the factors thought to underlie prolonged relapse is conditioned alcohol craving brought forth by the presence of alcohol or other cues associated with drinking, that is, cue‐elicited craving 45 . Given the strong clinical relevance of cue‐induced craving, our understanding of the time course of reactivity to alcohol cues with progressive abstinence in humans has been grossly insufficient.…”

Section: Discussionmentioning

confidence: 99%

Incubation of alcohol craving as it naturally occurs in a developmentally diverse sample of dependent and nondependent drinkers

Padovano

Miranda

2020

Addiction Biology

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Longer periods of abstinence are shown to enhance response to alcohol cues among alcohol‐dependent animals and humans, a phenomenon described as “incubation of craving.” The present work examined the effects of days since last drink on general craving and alcohol‐cued craving as it occurs in daily life and explored whether effects were influenced by age and dependence. Three samples were combined to include 266 drinkers ranging in age from 14 to 67 years recruited from the community; about half (59.4%) met criteria for alcohol dependence. Drinkers used handheld electronic devices to rate their subjective alcohol craving (assessed as “urge to drink”) and situational context (e.g., presence of visible alcohol cues) at nondrinking times in daily life, with days since last alcohol use culled from timeline follow‐back interviews and real‐world reports. Drinkers at the lower end of the age range in this sample reported greater intensification of craving with more days of continuous abstinence than drinkers at the upper end of the age range. Age was not related to incubation of cue‐elicited craving, in specific, however. For drinkers with dependence, craving when in the presence of visible alcohol cues intensified with more days of continuous abstinence, suggesting craving incubation. This study builds from important foundational work to demonstrate that incubation of cue‐elicited craving occurs in dependent drinkers and applies regardless of age. Inasmuch as craving is a motivational drive that maintains alcohol use, understanding factors that influence craving in daily life holds promise for improving clinical care.

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Section: Discussionmentioning

confidence: 99%

Incubation of alcohol craving as it naturally occurs in a developmentally diverse sample of dependent and nondependent drinkers

Padovano

Miranda

2020

Addiction Biology

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“…The amygdala plays a central role in the modulation of incentive salience to cues (Cunningham and Brosch, 2012), the formation and consolidation of emotional memories and in Pavlovian conditioned learning (Koob and Volkow, 2010;Mahler and Berridge, 2009). As discussed in the previous paragraph, the amygdala has played a strong role in the anxiety attentional bias (Carlson et al, 2013;Hardee et al, 2013;Monk et al, 2006), and often correlates with craving in patients with AUD (Wiers and Heinz, 2015;Wiers et al, 2014). Behavioral studies of inhibition training showed that the inhibition of responses to stimuli that were initially positively valenced resulted in a devaluation of this stimulus category (Veling and Aarts, 2009;Veling et al, 2008).…”

Section: Hypothesized Working Mechanisms Of Cbmmentioning

confidence: 99%

Imaging the neural effects of cognitive bias modification training

Wiers

2017

NeuroImage

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Cognitive bias modification (CBM) was first developed as an experimental tool to examine the causal role of cognitive biases, and later developed into complementary interventions in experimental psychopathology research. CBM involves the "re-training" of implicit biases by means of multiple trials of computerized tasks, and has been demonstrated to change anxious, depressive and drug-seeking behavior, including clinically relevant effects. Recently, the field has progressed by combining CBM with neuroimaging techniques, which provides insight into neural mechanisms underlying how CBM affects implicit biases in anxiety, depression, and addiction, and potentially other pathologies. This narrative literature review summarizes the state of the art of studies on the neural effects of CBM and provides directions for future research in the field. A total of 13 published studies were found and discussed: n=9 in anxiety, n=2 in depressive behavior, and n=2 in addiction.

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“…Craving for alcohol that is evoked by cues or settings associated with drinking is one clinical manifestation of AUD (Bickel et al, 2019; Koob & Volkow, 2016; Volkow et al, 2016). Provoked craving, or “cue reactivity,” is important because of the diagnostic and prognostic utility of its behavioral and neurobiological correlates and potential relevance as a treatment target (Wiers & Heinz, 2015). When considering adolescent and young‐adult substance use, the relevance of interpersonal, peer influences for understanding intrapersonal, subjective experiences is hard to overstate (Dimoff & Sayette, 2017; Fairbairn & Sayette, 2014).…”

Section: Discussionmentioning

confidence: 99%

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Meisel

Padovano

Pielech

et al. 2023

Alcohol: Clinical and Experimental Research

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Background Although peers figure prominently in developmental models of alcohol use, our understanding of the influence of peer social context in cue reactivity paradigms with adolescents and emerging adults in the human laboratory and the natural environment is limited. This study tested associations between alcohol craving among youth in the human laboratory using alcohol‐related images, with and without peers, and in the natural environment using ecological momentary assessment (EMA). Methods Data for this preregistered secondary analysis were collected prior to randomization in two medication trials (N = 115). Participants completed an image cue exposure paradigm at the baseline laboratory session followed by approximately 7 days of EMA. Results In the laboratory, model‐based mean comparisons from multilevel models (MLMs) showed that all drinking images elicited greater craving than neutral images. No differences were observed across the three image categories containing alcohol. Image category by age interactions demonstrated that, compared to older youth, younger youth displayed lower craving in response to neutral versus social drinking context with peers images and older, compared to younger, youth displayed higher craving in response to nonsocial drinking images versus social drinking contexts with peers images. In the natural environment, craving was greatest when youth were in the presence of alcohol‐using peers and alcohol‐related cues, regardless of age. Laboratory craving to alcohol images was positively associated with craving in the natural environment. Conclusions For youth, peers are a salient social context associated with increased craving, particularly in the natural environment. Laboratory cue reactivity to alcohol images predicted real‐world craving, further supporting the ecological validity of this paradigm in youth.

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Neurobiology of Alcohol Craving and Relapse Prediction

Cited by 9 publications

References 115 publications

Incubation of alcohol craving as it naturally occurs in a developmentally diverse sample of dependent and nondependent drinkers

Incubation of alcohol craving as it naturally occurs in a developmentally diverse sample of dependent and nondependent drinkers

Imaging the neural effects of cognitive bias modification training

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

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