Neuroblastoma consensus deletion maps to 1p36.1–2

Weith, Andreas; Martinsson, Tommy; Cziepluch, Celina; Brüderlein, Silke; Amler, Lukas C.; Berthold, Frank; Schwab, Manfred

doi:10.1002/gcc.2870010209

Cited by 162 publications

(88 citation statements)

References 28 publications

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“…Similar results have been obtained independently by other investigators (Weith et al, 1989). Loss or inactivation of a putative neuroblastoma suppressor gene at this site may be critical for the development or progression of neuroblastoma.…”

Section: Common Region Of Loh In Neuroblastomassupporting

confidence: 89%

Biology of tumors of the peripheral nervous system

Brodeur

Moley

1991

Cancer Metast Rev

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Section: Common Region Of Loh In Neuroblastomassupporting

confidence: 89%

Biology of tumors of the peripheral nervous system

Brodeur

Moley

1991

Cancer Metast Rev

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“…Our results demonstrated that a region commonly deleted in gastric adenocarcinomas is located between DIS201 and DlS197. 427 tumours have implied the presence of a putative tumoursuppressor gene(s) on chromosome 1; these results have been reported in colorectal cancers (Leister et al, 1990;Bardi et al, 1993), hepatocellular carcinomas (Simon et al, 1991;Yeh et al, 1994), neuroblastomas (Fong et al, 1989;Weith et al, 1989;Schleiermacher et al, 1994;Takeda et al, 1994), phaeochromocytomas and medullary thyroid carcinomas (Mathew et al, 1987;Moley et al, 1992) and breast cancers (Bieche et al, 1993;Dracopoli et al, 1994;Loupart et al, 1995). As the commonly deleted region we have observed in gastric cancers overlaps with the commonly deleted regions reported in various other tissues (Mathew et al, 1987;Fong et al, 1989;Leister et al, 1990;Moley et al, 1992), inactivation of the same unidentified tumour-suppressor gene(s) on the short arm of chromosome 1 may be associated with more than one type of cancer.…”

Section: Discussionmentioning

confidence: 89%

Deletion mapping on chromosome 1p in well-differentiated gastric cancer

Ezaki

Yanagisawa²,

Ohta³

et al. 1996

Br J Cancer

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Summary To define the region on the short arm of chromosome 1 that is thought to include one or more tumour-suppressor genes for gastric cancers, we carried out loss of heterozygosity (LOH) studies in 26 gastric adenocarcinomas, using three restriction fragment length polymorphism (RFLP) markers and nine microsatellite markers. All tumours were informative with at least one locus; three revealed replication errors (RERs) at multiple microsatellite loci, and interstitial or telomeric allelic deletions were observed in 12 cases. Deletion mapping of these tumours defined a commonly deleted region between two loci, DlS201 and DlS197, that are 13 cM apart. As two loci within the commonly deleted region, D1S57 (pYNZ2) and D1S62 (pTHI54), were mapped respectively to lp35 and lp34.3 by fluorescence in situ hybridisation, we conclude that a locus likely to contain a tumour-suppressor gene for gastric cancer is located within a 13 cM region encompassing these two chromosomal bands. (Deng et al., 1987;Kihana et al., 1991) and p53 (Tamura et al., 1991;Strickler et al., 1994) genes. Amplification of the erbB-2 gene and mutations of the APC and ras genes are found frequently in well-differentiated adenocarcinomas but not in poorly differentiated adenocarcinomas (Yokota et al., 1988;Kihana et al., 1991;. In contrast, amplification of the K-sam gene and replication errors (RERs) at microsatellite loci have been detected preferentially in poorly differentiated adenocarcinomas (Hattori et al., 1990;Han et al., 1993). These observations imply that the genetic pathways involved in development of these two histopathologically distinguished forms of gastric adenocarcinoma are likely to be different.Recent results of LOH studies have suggested that loci containing tumour-suppressor genes associated with gastric carcinogenesis exist on chromosomal arms lp, lq, 5q, 7q, 12q 17p and 18q (Sano et al., 1991;Uchino et al., 1992; Kuniyasu et al., 1995). As part of a strategy to identify these putative tumour-suppressor genes we began by attempting to define the region on chromosome lp that is commonly deleted in gastric cancers. Here we report results of LOH studies in 26 well-differentiated adenocarcinomas of the stomach. Materials and methodsPreparation of samples and DNA A total of 26 paired samples of tumours and corresponding normal tissues removed from Japanese patients with welldifferentiated adenocarcinomas of the stomach were obtained at the Cancer Institute Hospital, Tokyo. In 18 cases the tissue samples were fixed in formalin, embedded in paraffin and attached individually to glass slides. Genomic DNA was extracted according to methods described elsewhere (Goelz et al., 1985;Yanagisawa et al., 1991). The remaining eight samples were frozen in liquid nitrogen after surgical resection and stored at -80°C until isolation of DNA. Genomic DNA was extracted from the frozen tissues according to methods described elsewhere (Sato et al., 1990).RFLP markers for LOH analysis The three RFLP markers used in this study, D1S77 (pMCT58), DIS57 (...

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“…One region of high incidence of LOH is at 1p36.2-3 and another is encompassed by larger deletions extending to 1p32. 14,15,[51][52][53] We also detected varying lengths of deletions of 1p36 with low risk tumors primarily exhibiting shorter regions of contiguous loss, but this association did not reach statistical significance. In addition, our study detected a high incidence of LOH at 1p22 apparently distinct from LOH at 1p36.…”

Section: Discussionmentioning

confidence: 99%