Neuroblastoma: Influence of age at diagnosis, stage, tumor site, and sex on prognosis

Coldman, Andy; Fryer, Christopher; Elwood, J Mark; Sonley, Marilyn

doi:10.1002/1097-0142(19801015)46:8<1896::aid-cncr2820460833>3.0.co;2-y

Cited by 138 publications

(45 citation statements)

References 8 publications

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“…It is well established that NB of any stage diagnosed in infants have a better prognosis than those diagnosed in children at the same stage [17,19,25,29]. In fact, the main NB prognostic categorization schemes based on morphological parameters were age-linked systems [32,48,49].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognostic factors: a study of 182 cases from the Spanish Neuroblastoma Registry

et al. 2006

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In addition to clinical and biological factors, further valuable prognostic information in neuroblastoma (Schwannian stroma-poor) (NB) patients is provided by the histopathologic analysis and the application of the International Neuroblastoma Pathology Classification (INPC) system. The objective of this study was to assess the prognostic impact of the INPC classification in a series of NB (Schwannian stroma-poor) and its relation with other prognostic factors. One hundred eighty-two cases of NB were collected from the files of the Spanish Neuroblastoma Registry. Slides were reviewed, and NB cases were grouped into favorable and unfavorable categories according to INPC criteria, taking into account morphological features (mitosis-karyorrhexis index, histological subtype) and patient's age at diagnosis. Other pathological [presence of calcifications, tissular components, and number of mitotic cells per 10 high-power field (HPF)], immunohistochemical (P-glycoprotein and Ki-67 protein expression) and genetic (MYCN amplification and chromosome 1p deletion) features were also studied. Statistical analyses of overall survival with Kaplan-Meier curves and a multivariate study using Cox regression were performed (40.3% of NBs were considered favorable and 59.7% unfavorable). Unfavorable NB showed a mean survival time of 57 months compared with 89 months in favorable cases. Advanced stage, more than ten mitoses per 10 HPF, Ki-67 expression in more than 30% of tumor cells, MYCN oncogene amplification and chromosome 1p deletion were observed more frequently in unfavorable NB. The Cox regression analysis demonstrated that clinical stage (International Neuroblastoma Staging System stage 4) and histological subtype (undifferentiated NB) were the most important factors that influence the overall survival (p<0.001). INPC classification results are major prognostic indicators in NB and should be considered in the therapeutic stratification of NB patients.

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Section: Discussionmentioning

confidence: 99%

“…Tumor stage is also an independent prognostic factor in NB: localized tumors have longer survival rates than disseminated ones [17,19]. In the multivariate analysis, we found that INSS stage 4 was the parameter with a more negative effect on hazard rate.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognostic factors: a study of 182 cases from the Spanish Neuroblastoma Registry

et al. 2006

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“…HE PROGNOSIS OF CHILDREN WITH TUMORS Of the T sympathetic nervous system has been shown to correlate highly with several clinical, biochemical, and histologic Shimada et al have recently shown that three morphologic features are particularly useful in predicting the behavior of these tumors: (1) the proportion of neuroblastic and Schwann's cells; (2) the extent of ganglion cell differentiation; and (3) the percentage of mitotic figures and karyorrhectic nuclei (mitotic karyorrhectic index, MKI). Flow cytometric DNA analysis (FCDA), like the MKI, provides information concerning growth lunetics.…”

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confidence: 99%

Flow cytometric DNA analysis of neuroblastoma. Correlation with histology and clinical outcome

Gansler

Chatten

Varello

et al. 1986

Cancer

118

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Clinical and histologic features of 38 cases of neuroblastoma were compared with data obtained by flow cytometric DNA analysis. Favorable clinical outcome was associated with an aneuploid stem line (P < 0.01) and a low percentage of tumor cells in the S, G I , and M phases of the cell cycle (P < 0.005).These favorable cytometric features were also associated with a favorable clinical stage (1, 2, 4s), and histologic evidence of Schwann's cell and ganglion cell differentiation. Consideration of cytometric data improved the sensitivity, specificity, and predictive efficiency of a current system for histologic grading of neuroblastoma.Cancer 58:2453-2458, 1986. HE PROGNOSIS OF CHILDREN WITH TUMORS Of theT sympathetic nervous system has been shown to correlate highly with several clinical, biochemical, and histologic Shimada et al. have recently shown that three morphologic features are particularly useful in predicting the behavior of these tumors: (1) the proportion of neuroblastic and Schwann's cells; (2) the extent of ganglion cell differentiation; and (3) the percentage of mitotic figures and karyorrhectic nuclei (mitotic karyorrhectic index, MKI). Flow cytometric DNA analysis (FCDA), like the MKI, provides information concerning growth lunetics. FCDA is also used to detect abnormal tumor DNA content (aneuploidy), which has been associated with a favorable outcome in cases of neur~blastoma.~ Previous studies from this and other laboratories have also demonstrated the usefulness of FCDA in the diagnosis of neoplastic and preneoplastic disorders of the uterine cervix, bladder, lung, breast, gastrointestinal tract, and other site^.^,^ In order to evaluate the prognostic value of FCDA of neuroblastoma and ganglioneuroblastoma, a retrospective study of 38 cases was undertaken. The percentage of cells in the S and G2/M phase ofthe cell cycle (%SG*M) showed a highly significant association with clinical outcome, and when incorporated into the histologic classi-

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“…Finally, we should explain the negative results of classical prognostic indicators such as age, [1][2][3][4] histological category or INPC Prognostic Group 5,6 in our series. Based on the literature and the recent published article by Sano and colleagues, 31 the International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age.…”

Section: Discussionmentioning

confidence: 99%

Morphometric Evaluation of Nb84, Synaptophysin and Agnor Is Useful for the Histological Diagnosis and Prognosis in Peripheral Neuroblastic Tumors (Pnts)

Carvalho

Parra

Zerbini

et al. 2007

Clinics

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Neuroblastoma: Influence of age at diagnosis, stage, tumor site, and sex on prognosis

Cited by 138 publications

References 8 publications

Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognostic factors: a study of 182 cases from the Spanish Neuroblastoma Registry

Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognostic factors: a study of 182 cases from the Spanish Neuroblastoma Registry

Flow cytometric DNA analysis of neuroblastoma. Correlation with histology and clinical outcome

Morphometric Evaluation of Nb84, Synaptophysin and Agnor Is Useful for the Histological Diagnosis and Prognosis in Peripheral Neuroblastic Tumors (Pnts)

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