Neurocognition in clinical high risk young adults who did or did not convert to a first schizophrenic psychosis: A meta-analysis

Herdt, Amber De; Wampers, Martien; Vancampfort, Davy; Hert, Marc De; Vanhees, Luc; Demunter, Hella; Bouwel, L Van; Brunner, Emanuel; Probst, Michel

doi:10.1016/j.schres.2013.06.017

Cited by 99 publications

(83 citation statements)

References 78 publications

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“…Such neurocognitive deficits are already present in individuals at high risk for the disorder (Agnew-Blais and Bora and Murray, 2013). More importantly, they have been suggested to be more severe in high-risk individuals who will later develop a psychotic disorder compared to those who will not (De Herdt et al, 2013). Identification of the neural networks involved in this core component of schizophrenia might help clarify the pathophysiological mechanisms that eventually lead to emergence of psychotic symptoms, and promote the development of interventions aiming to prevent transition into a chronic and difficult-to-treat disorder.…”

Section: Introductionmentioning

confidence: 99%

Resting-state theta-band connectivity and verbal memory in schizophrenia and in the high-risk state

Andreou

Leicht

Nolte

et al. 2015

Schizophrenia Research

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Section: Introductionmentioning

confidence: 99%

Resting-state theta-band connectivity and verbal memory in schizophrenia and in the high-risk state

Andreou

Leicht

Nolte

et al. 2015

Schizophrenia Research

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“…7 Consistent with these findings, a recent meta-analysis has suggested that it is possible to differentiate between clinical high-risk individuals who transition or do not transition to psychosis with respect to working memory. 8 Functional magnetic resonance imaging (fMRI) studies have shown that working memory deficits in individuals with an ARMS are accompanied by reduced activation in frontal and parietal brain regions. [9][10][11] Moreover, the reduced prefrontal activation in individuals with an ARMS during a working memory task is associated with a reduction in grey matter volume in the same area.…”

Section: Introductionmentioning

confidence: 99%

Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state

Schmidt

Smieskova

Simon

et al. 2014

J Psychiatry Neurosci

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“…Working memory deficits are a core cognitive feature of psychotic disorders (Lee and Park, 2005) (De et al, 2013) (Kelleher et al, 2013a) (Koychev et al, 2012) (Reichenberg and Harvey, 2007). Working memory encompasses a variety of cognitive processes ranging from relatively simple encoding and maintenance to more complex manipulation of stored information.…”

mentioning

confidence: 99%

Working memory impairment in probands with schizoaffective disorder and first degree relatives of schizophrenia probands extend beyond deficits predicted by generalized neuropsychological impairment

Hill

Buchholz

Amsbaugh

et al. 2015

Schizophrenia Research

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Objective Working memory impairment is well established in psychotic disorders. However, the relative magnitude, diagnostic specificity, familiality pattern, and degree of independence from generalized cognitive deficits across psychotic disorders remain unclear. Method Participants from the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study included probands with schizophrenia (N=289), psychotic bipolar disorder (N=227), schizoaffective disorder (N=165), their first-degree relatives (N=315, N=259, N=193, respectively), and healthy controls (N=289). All were administered the WMS-III Spatial Span working memory test and the Brief Assessment of Cognition in Schizophrenia (BACS) battery. Results All proband groups displayed significant deficits for both forward and backward span compared to controls. However, after covarying for generalized cognitive impairments (BACS composite), all proband groups showed a 74% or greater effect size reduction with only schizoaffective probands showing residual backward span deficits compared to controls. Significant familiality was seen in schizophrenia and bipolar pedigrees. In relatives, both forward and backward span deficits were again attenuated after covarying BACS scores and residual backward span deficits were seen in relatives of schizophrenia patients. Conclusions Overall, both probands and relatives showed a similar pattern of robust working memory deficits that were largely attenuated when controlling for generalized cognitive deficits.

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Neurocognition in clinical high risk young adults who did or did not convert to a first schizophrenic psychosis: A meta-analysis

Cited by 99 publications

References 78 publications

Resting-state theta-band connectivity and verbal memory in schizophrenia and in the high-risk state

Resting-state theta-band connectivity and verbal memory in schizophrenia and in the high-risk state

Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state

Working memory impairment in probands with schizoaffective disorder and first degree relatives of schizophrenia probands extend beyond deficits predicted by generalized neuropsychological impairment

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