Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group

Simonsen, Carmen; Sundet, Kjetil; Vaskinn, Anja; Birkenaes, Astrid B.; Engh, John Abel; Færden, Ann; Jónsdóttir, Halldóra; Ringen, Petter Andreas; Opjordsmoen, Stein; Melle, Ingrid; Friis, Svein; Andreassen, Ole A.

doi:10.1093/schbul/sbp034

Cited by 280 publications

(291 citation statements)

References 41 publications

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“…However, Harkavy-Friedman et al (2006) did not find significant differences between BD I and BD II patients with a depressive episode and suicide attempts and HCs. Simonsen et al (2011) investigated whether neurocognitive dysfunction depends more on the history of psychosis or the diagnostic subtype and found that the latter only had significant main effect on two verbal recall measures, whereas history of psychosis influenced all subscores.…”

Section: Verbal Memorymentioning

confidence: 99%

Are bipolar II patients cognitively impaired? A systematic review

et al. 2011

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Background. There is evidence that bipolar disorder (BD) is associated with significant neurocognitive deficits and this occurs in individuals with BD type I (BD I) and with BD type II (BD II). Only a few studies have focused on cognitive impairment in BD II. The aim of this study was to describe the pattern of cognitive impairment in patients with BD II, in order to identify specific cognitive deficits that distinguish BD II from BD I patients as well as from healthy subjects.Method. We performed a systematic review of the literature of neuropsychological studies of BD II published between 1980 and July 2009. Fourteen articles fulfilled the inclusion criteria and were included in this review.Results. Main cognitive deficits found in BD II include working memory and some measures of executive functions (inhibitory control) and approximately half of the studies also detected verbal memory impairment.Conclusions. There are subtle differences between the two subtypes regarding cognition. This may suggest neurobiological differences between the two subgroups which will be helpful in order to determine cognitive endophenotypes in BD subtypes.

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Section: Verbal Memorymentioning

confidence: 99%

Are bipolar II patients cognitively impaired? A systematic review

et al. 2011

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“…2,5,8 Nevertheless, the mechanisms underlying this association are not well understood. 1,2,9 Cognitive dysfunctions are central to schizophrenia and BD, [10][11][12][13] and recent data suggest that the cognitive decline begins in childhood. 14,15 The cognitive impairments that are typically shared by patients with schizophrenia and BD 12,16,17 have a genetic basis, 18,19 which does not preclude environmental influences from further impacting the developmental trajectory.…”

Section: Introductionmentioning

confidence: 99%

Childhood abuse and neglect may induce deficits in cognitive precursors of psychosis in high-risk children

Berthelot

Paccalet

Gilbert

et al. 2015

jpn

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“…This reflects overlap between affective and psychotic disorders in genetic ) and environmental risk factors (Weiser et al 2005), as well as in underlying endophenotypes, for example (neuro)cognitive, social and emotional dysfunctions (Weiser et al 2005;Hill et al 2009;Simonsen et al 2011). The overlap in diagnostic constructs has important implications for both research and clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

Wigman

Abidi

et al. 2013

Psychol. Med.

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Background. Subthreshold psychotic and bipolar experiences are common in major depressive disorder (MDD). However, it is unknown if effectiveness of psychotherapy is altered in depressed patients who display such features compared with those without. The current paper aimed to investigate the impact of the co-presence of subclinical psychotic experiences and subclinical bipolar symptoms on the effectiveness of psychological treatment, alone or in combination with pharmacotherapy.Method. In a naturalistic study, patients with MDD (n = 116) received psychological treatment (cognitive behavioural therapy or interpersonal psychotherapy) alone or in combination with pharmacotherapy. Depression and functioning were assessed six times over 2 years. Lifetime psychotic experiences and bipolar symptoms were assessed at the second time point.Results. Subclinical psychotic experiences predicted more depression over time (β = 0.20, p < 0.002), non-remission [odds ratio (OR) 7.51, p < 0.016] and relapse (OR 3.85, p < 0.034). Subthreshold bipolar symptoms predicted relapse (OR 1.16, p < 0.037).Conclusions. In general, subclinical psychotic experiences have a negative impact on the course and outcome of psychotherapy in MDD. Effects of subclinical bipolar experiences were less prominent.

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Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group

Cited by 280 publications

References 41 publications

Are bipolar II patients cognitively impaired? A systematic review

Are bipolar II patients cognitively impaired? A systematic review

Childhood abuse and neglect may induce deficits in cognitive precursors of psychosis in high-risk children

Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

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