Neurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: An event-related fMRI study

Raedt, Rudi De; Leyman, Lemke; Baeken, Chris; Schuerbeek, Peter Van; Luypaert, Robert; Vanderhasselt, Marie‐Anne; Dannlowski, Udo

doi:10.1016/j.biopsycho.2010.09.015

Cited by 120 publications

(110 citation statements)

References 57 publications

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“…At behavioral level, they showed longer RTs for incompatible compared to compatible conditions comprising clear SRC effects for both positive and negative pictures. These results are in line with studies showing emotional information to cause deactivation of prefrontal regulation areas, whereby material with a negative valence specifically deactivated the right DLPFC [53,54]. Such a mechanism might have reduced activity in the right DLPFC for negative compared to positive pictures and might have lowered cognitive regulation resulting in SRC effects at behavioral level, i.e.…”

Section: Discussionsupporting

confidence: 90%

Genetic Variation in MAOA Modulates Prefrontal Cortical Regulation of Approach-Avoidance Reactions

Ernst

Lutz²,

Ehlis

et al. 2013

Neuropsychobiology

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Background: Regulation of automatic approach and avoidance behavior requires affective and cognitive control, which are both influenced by a genetic variation in the gene encoding Monoamine Oxidase A (termed MAOA-uVNTR). Methods: The current study investigated MAOA genotype as a moderator of prefrontal cortical activation measured with functional near-infrared spectroscopy (fNIRS) in 37 healthy young adults during performance of the approach-avoidance task with positive and negative pictures. Results: Carriers of the low- compared to the high-expressing genetic variant (MAOA-L vs. MAOA-H) showed increasing regulatory activity in the right dorsolateral prefrontal cortex (DLPFC) during incompatible conditions (approach negative, avoid positive). This might have been a compensatory mechanism for stronger emotional reactions as shown in previous studies and might have prevented any influence of incompatibility on behavior. In contrast, fewer errors but also lower activity in the right DLPFC during processing of negative compared to positive stimuli indicated MAOA-H carriers to have used other regulatory areas. This resulted in slower reaction times in incompatible conditions, but - in line with the known better cognitive regulation efficiency - allowed them to perform incompatible reactions without activating the DLPFC as the highest control instance. Carriers of one low- and one high-expressing allele lay as an intermediate group between the reactions of the low- and high-expressing groups. Conclusions: The relatively small sample size and restriction to fNIRS for assessment of cortical activity limit our findings. Nevertheless, these first results suggest monoam-inergic mechanisms to contribute to interindividual differences in the two basic behavioral principles of approach and avoidance and their neuronal correlates.

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Section: Discussionsupporting

confidence: 90%

Genetic Variation in MAOA Modulates Prefrontal Cortical Regulation of Approach-Avoidance Reactions

Ernst

Lutz²,

Ehlis

et al. 2013

Neuropsychobiology

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“…As in previous studies on ABTs (e.g., Leyman et al, 2009; De Raedt et al, 2010), only female participants were included in the study to ensure maximum homogeneity of the sample, and because women are considered to show greater facility in decoding non-verbal messages and to rate their emotions more intensely than males (Killgore and Yurgelun-Todd, 2001). …”

Section: Methodsmentioning

confidence: 99%

Attentional biases toward threat: the concomitant presence of difficulty of disengagement and attentional avoidance in low trait anxious individuals

et al. 2014

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Attentional biases toward threats (ABTs) have been described in high anxious individuals and in clinical samples whereas they have been rarely reported in non-clinical samples (Bar-Haim et al., 2007; Cisler and Koster, 2010). Three kinds of ABTs have been identified (facilitation, difficulty of disengagement, and avoidance) but their mechanisms and time courses are still unclear. This study aimed to understand ABTs mechanisms and timing in low trait anxiety (LTA) and high trait anxiety (HTA) anxious individuals. In particular, in an exogenous cueing task we used threatening or neutral stimuli as peripheral cues with three presentation times (100, 200, or 500 ms). The main results showed that HTA individuals have an attentional facilitation bias at 100 ms (likely automatic in nature) whereas LTA individuals show attentional avoidance and difficulty to disengage from threatening stimuli at 200 ms (likely related to a strategic processing). Such findings demonstrate that threat biases attention with specific mechanisms and time courses, and that anxiety levels modulate attention allocation.

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“…In summary, rTMS can influence attentional aspects of emotion regulation [15,75], affective processing of emotional stimuli [87], and autonomic reactions to affective pictures [3]. Also, these studies show that rTMS applied to the cerebellum can affect mood in emotion regulation [68].…”

Section: Emotion Regulation Rtmsmentioning

confidence: 69%

“…In addition, state anxiety prior to stimulation correlated positively with induced attentional bias. Another study [15] investigated the effects of HF rTMS over the right or left DLPFC on the attentional processing of [87]. The study measured MEG activation for fearful and neutral faces as well as gender discrimination before and after rTMS.…”

Section: Emotion Regulation Rtmsmentioning

confidence: 99%

The modulating effects of brain stimulation on emotion regulation and decision-making

Choi

Scott

Lim

2016

Neuropsychiatr Electrophysiol

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Background: It has been reported that brain stimulation such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) can modulate a variety of cognitions and emotions in humans. rTMS and tDCS studies provide strong possibilities of applications in the manipulation of emotion regulation and decision-making in humans. Methods: We searched the literature by using keywords "rTMS," "tDCS," "emotion regulation," and "decision-making" on PubMed (http://www.ncbi.nlm.nih.gov/pubmed). Based on the search results, we reviewed studies on emotion regulation and decision-making using rTMS and tDCS modulations.

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Neurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: An event-related fMRI study

Cited by 120 publications

References 57 publications

Genetic Variation in <b><i>MAOA</i></b> Modulates Prefrontal Cortical Regulation of Approach-Avoidance Reactions

Genetic Variation in <b><i>MAOA</i></b> Modulates Prefrontal Cortical Regulation of Approach-Avoidance Reactions

Attentional biases toward threat: the concomitant presence of difficulty of disengagement and attentional avoidance in low trait anxious individuals

The modulating effects of brain stimulation on emotion regulation and decision-making

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