The modulating effects of brain stimulation on emotion regulation and decision-making

Choi, Kyung Mook; Scott, David T.; Lim, Seung-Lark

doi:10.1186/s40810-016-0018-z

Cited by 14 publications

(11 citation statements)

References 85 publications

(154 reference statements)

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“…Previous brain stimulation research involving transcranial direct current stimulation (tDCS), as well as rTMS protocols, has indicated that transcranial brain stimulation over the DLPFC improves emotion processing in both healthy and patient populations, by inhibiting negative bias and increasing excitability for positive stimuli (Brunoni et al, 2014;Guo et al, 2019;Ironside, O'Shea, Cowen, & Harmer, 2016;Nitsche et al, 2012). Authors argue that stimulation methods such as rTMS, if applied over the left PFC, can modulate affective processing (Choi, Scott, & Lim, 2016;Schutter & van Honk, 2005). For instance, a study performed in a schizophrenic cohort showed that rTMS improved facial affect recognition (Wölwer et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Dumitru

Rocchi

Saini

et al. 2020

Cogn Affect Behav Neurosci

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Repetitive transcranial magnetic stimulation is a potential treatment option for depression, with the newer intermittent theta-burst stimulation (iTBS) protocols providing brief intervention. However, their mechanism of action remains unclear. We investigated the hypothesis that iTBS influences brain circuits involved in emotion processing that are also affected by antidepressants. We predicted that iTBS would lead to changes in performance on emotion-processing tasks. We investigated the effects of intermittent TBS (iTBS) over the left dorsolateral prefrontal cortex (DLPFC) on the processing of emotional information (word recall and categorization, facial emotion recognition, and decision-making) in 28 healthy volunteers by contrasting these effects with those of sham stimulation. Each volunteer received iTBS and sham stimulation in a blinded crossover design and completed the emotion-processing tasks before and after stimulation. Compared to sham stimulation, iTBS increased positive affective processing for word recall, yet had an unexpected effect on facial emotion recognition for happy and sad faces. There was no evidence of an effect on decision-making or word categorization. We found support for our hypothesis that iTBS influences emotion processing, though some changes were not in the expected direction. These findings suggest a possible common mechanism of action between iTBS and antidepressants, and a complex neural circuitry involved in emotion processing that could potentially be tapped into via brain stimulation. Future research should investigate the neural correlates of emotion processing more closely to inform future iTBS protocols.

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Section: Introductionmentioning

confidence: 99%

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Dumitru

Rocchi

Saini

et al. 2020

Cogn Affect Behav Neurosci

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“…These studies vary in their methodology and reveal contradictory results with high-frequency right dlPFC rTMS being associated with an increase in attentional bias toward negative stimuli (34), whereas high-frequency left dlPFC stimulation decreased the amygdala response to negative stimuli (35). Additionally, a recent review concludes that rTMS influences cognitive control and the attentional and affective aspects of emotion regulation and that rTMS should be investigated for substance use disordered patients (33, 36).…”

Section: Introductionmentioning

confidence: 99%

The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls: A Functional Magnetic Resonance Imaging Study

et al. 2019

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Impaired cognitive–motivational functioning is present in many psychiatric disorders, including alcohol use disorder (AUD). Emotion regulation is a key intermediate factor, relating to the (cognitive) regulation of emotional and motivational states, such as in regulation of craving or negative emotions that may lead to relapse in alcohol use. These cognitive–motivational functions, including emotion regulation, are a target in cognitive behavioral therapy and may possibly be improved by neurostimulation techniques. The present between-subjects, single-blind study assesses the effects of sham-controlled high-frequency neuronavigated repetitive transcranial magnetic stimulation (10 Hz) of the right dorsolateral prefrontal cortex (dlPFC) on several aspects relevant for emotion regulation (emotion processing and reappraisal abilities) and related brain activity, as well as self-reported craving in a sample of alcohol use disorder patients (AUD; n = 39) and healthy controls (HC; n = 36). During the emotion reappraisal task, participants were instructed to either attend or reappraise their emotions related to the negative, positive, neutral, and alcohol-related images, after which they rated their experienced emotions. We found that repetitive transcranial magnetic stimulation (rTMS) reduces self-reported experienced emotions in response to positive and negative images in AUD patients, whereas experienced emotions were increased in response to neutral and positive images in HCs. In the functional magnetic resonance imaging (fMRI) analyses, we found that rTMS reduces right dlPFC activity during appraisal of affective images relative to sham stimulation only in AUD patients. We could not confirm our hypotheses regarding the effect of rTMS craving levels, or on reappraisal related brain function, since no significant effects of rTMS on craving or reappraisal related brain function were found. These findings imply that rTMS can reduce the emotional impact of images as reflected in blood oxygenation level-dependent (BOLD) response, especially in AUD patients. Future studies should replicate and expand the current study, for instance, by assessing the effect of multiple stimulation sessions on both explicit and implicit emotion regulation paradigms and craving, and assess the effect of rTMS within subgroups with specific addiction-relevant image preferences. Clinical Trial Registration: , identifier NCT02557815.

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“…The tDCS, in fact, leads to a reduction in drug craving through inducing changes in dopaminergic neurotransmission in the brain and reducing cortical arousal (10). In addition, tDCS reduces drug craving through influencing the DLPFC area of the prefrontal cortex (11).…”

Section: Introductionmentioning

confidence: 99%

“…Through the anodal stimulation of the right DLPFC (according to the international 10 -20 system of electrode placement) and the cathodal stimulation of the left supraorbital area of the frontal lobe, tDCS reduces the skin conductance response (SCR) and emotional arousal that, in turn, leads to reduced craving (11).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the future of neuromodulation for treating drug use and other psychiatric disorders requires more rigorous research. The current prominent theory maintains that combining brain stimulation with other therapies can increase the efficacy of treatment (11). In addition to tDCS, the efficacy of emotion regulation training and related techniques in reducing drug craving has been shown in different studies (4,(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Transcranial Direct-Current Stimulation (tDCS) and Emotion Regulation Training in Reducing Current Drug Craving and Drug-Use Thoughts and Fantasies in Opioid-Dependent Patients: The Issue of Precedence

Kooteh

Bakhshani

Nosratabadi

et al. 2019

Int J High Risk Behav Addict

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Background: Craving is an important factor in predicting relapse in opioid-dependent patients. Objectives: The aim of the present study was to determine which combination therapy, including emotion regulation training followed by tDCS or tDCS followed by emotion regulation training, is more effective in reducing current drug craving and drug-use thoughts and fantasies in opioid-dependent patients in Zahedan, Iran. Patient and Methods: A quasi-experimental study with a pretest-posttest design and two intervention groups was conducted. From eight randomly-selected centers, asample of 28 patients was selected based on the inclusion and exclusion criteria. They were randomly divided into two intervention groups. The first group received eight sessions of tDCS, followed by eight sessions of emotion regulation training. The second group received eight sessions of emotion regulation training followed by eight sessions of tDCS. The statistical population included all opioid-dependent patients at medium-term residential drug rehabilitation centers in Zahedan, Iran, in 2018-2019. The data were gathered using the personal drug use questionnaire, the desires for drug questionnaire (DDQ), and the drug use thoughts, fantasies, and temptations questionnaire. All analyses were performed using SPSS-16. Results: The results of repeated measures ANOVA showed that both sequences had a significant, long-term effect on the reduction of current drug craving and drug-use thoughts and fantasies in opioid-dependent patients. In addition, emotion regulation training followed by tDCS was more effective in reducing current drug craving and drug-use thoughts and fantasies than tDCS followed by emotion regulation training. Conclusions: Combination therapy can significantly reduce drug craving in opioid-dependent patients and starting treatment with emotion regulation training followed by tDCS can lead to better results.

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The modulating effects of brain stimulation on emotion regulation and decision-making

Cited by 14 publications

References 85 publications

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls: A Functional Magnetic Resonance Imaging Study

Effectiveness of Transcranial Direct-Current Stimulation (tDCS) and Emotion Regulation Training in Reducing Current Drug Craving and Drug-Use Thoughts and Fantasies in Opioid-Dependent Patients: The Issue of Precedence

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