Neurocognitive endophenotypes for bipolar disorder

Frantom, Linda; Allen, Daniel N.; Cross, Chad L.

doi:10.1111/j.1399-5618.2007.00529.x

Cited by 79 publications

(65 citation statements)

References 78 publications

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“…Since memorizing two target colors at the beginning of each block was essential for successful task performance in the present paradigm, reduced activation in this region in bipolar patients, which was significantly correlated with their reduced performance rates in correct target acceptance, could indicate a disturbance of such working memory processes. These findings are in line with reports of visuospatial and working memory deficits in BD (Frantom et al, 2008;Lera-Miguel et al, 2011;Pan et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder

Trost

Diekhof

Zvonik

et al. 2014

Neuropsychopharmacol

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Bipolar disorder (BD) is characterized by recurrent mood episodes ranging from severe depression to acute full-blown mania. Both states of this severe psychiatric disorder have been associated with alterations of reward processing in the brain. Here, we present results of a functional magnetic resonance imaging (fMRI) study on the neural correlates and functional interactions underlying reward gain processing and reward dismissal in favor of a long-term goal in bipolar patients. Sixteen medicated patients diagnosed with bipolar I disorder, euthymic to mildly depressed, and sixteen matched healthy controls performed the 'desire-reason dilemma' (DRD) paradigm demanding rejection of priorly conditioned reward stimuli to successfully pursue a superordinate goal. Both groups exhibited significant activations in reward-related brain regions, particularly in the mesolimbic reward system. However, bipolar patients showed reduced neural responses of the ventral striatum (vStr) when exploiting a reward stimulus, and exhibited a decreased suppression of the rewardrelated activation of the mesolimbic reward system while having to reject immediate reward in favor of the long-term goal. Further, functional interaction between the anteroventral prefrontal cortex and the vStr in the 'DRD' was significantly impaired in the bipolar group. These findings provide evidence for a reduced responsivity of the vStr to reward stimuli in BD, possibly related to clinical features like anhedonia. The disturbed top-down control of mesolimbic reward signals by prefrontal brain regions in BD can be interpreted in terms of a disease-related enhanced impulsivity, a trait marker of BD.

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Section: Discussionsupporting

confidence: 93%

Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder

Trost

Diekhof

Zvonik

et al. 2014

Neuropsychopharmacol

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“…Researchers proposed neurocognitive deficits as a vulnerability marker or endophenotypes for the development of bipolar I disorder. 1,3,4 However, evidence is insufficient to conclude neurological deficits as important genetic vulnerability markers for the bipolar I disorder. Hence the objective of this study was to determine if any compromise in cognitive function could be linked to the genes and thus be viewed as endophenotypes of bipolar disorder.…”

mentioning

confidence: 99%

Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls

et al. 2017

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Background: Bipolar patients often suffer from debilitating cognitive impairment in different stages of the disease (manic, depressive or euthymic states). We assessed and compared the frequency of neurocognitive deficit among individual with bipolar I disorder but currently in euthymic state, their first-degree blood relatives and healthy controls. In addition, we also probed further into the type of neurocognitive deficit that can be seen among them and observed the influence of sociodemographic characteristics with the occurrence of neurocognitive deficit in individual with bipolar I disorder patient.Methods: Patients (N=30) who fulfilled the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV TR) criteria for bipolar I disorder but currently in remission were assessed for any neurological deficits using the standard instruments. In this study, 30 first-degree blood relatives of bipolar I disorder patients and selected 30 hospital staff as healthy controls were also assessed for neurological deficits.Results: We did not find any significant frontal dysfunction among first-degree blood relatives of bipolar I disorder patient when compared with euthymic bipolar I disorder patients. Factor that significantly affected neurocognitive performance in the bipolar patients who were in euthymic state included age, total duration of illness and number of manic episode.Conclusions: As neurocognitive impairment is associated with number of manic episode and total duration of illness; the objective of treatment should be to prolong remission and impart psychoeducation regarding nature of illness. On the contrary, anticipating definite cognitive impairment in first-degree blood relatives of bipolar I disorder patient when compared to healthy control warrants periodic neurocognitive testing and psychoeducation about deficit and medical intervention, if required.

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“…This impairment is reported to be similar in euthymic BD patients and patients with schizophrenia when results are controlled for possible confounding factors (Addington and Addington 1998 ). In general, the unaffected relatives demonstrated an intermediate level of performance in comparison to the normal control and bipolar group (Frantom et al 2008 ). On the contrary, the visual motion integration was reported to be intact in BD patients (Chen et al 2005 ).…”

Section: Visuospatial Skillsmentioning

confidence: 77%

“…Reasoning seems to rely heavily on verbal and linguistic skills and thus in BD patients it might be important to consider it separately from the rest of the executive functions (Goodwin and Jamison 2007 ). Signifi cant impairment in executive functions except reasoning is reported to be present during all phases of BD (Elshahawi et al 2011 ;Barrett et al 2009 ;Frangou et al 2005a ;Frantom et al 2008 ;Goswami et al 2006 ;Martinez-Aran et al 2002Hsiao et al 2009 ;Martino et al 2011a ;Mur et al 2007 ;Rossi et al 2000 ;Sanchez-Morla et al 2009 ;Torralva et al 2012 ;Wolf et al 2010 ;Borkowska and Rybakowski 2001 ;Malhi et al 2007a ;Antila et al 2007aAntila et al , 2009Dittmann et al 2008a ;Basso et al 2009 ;Glahn et al 2007 ;Zubieta et al 2001 ;Tam et al 1998 ;Tien et al 1996 ;Brambilla et al 2007 ;Morice 1990 ;Coffman et al 1990 ;Seidman et al 2002 ;Fitzgerald et al 2004 ;Bora et al 2007 ;Selva et al 2007 ;Simonsen et al 2011 ;Dittmann et al 2008b ;Malloy-Diniz et al 2009 ;Ali et al 2000 ;Waddington et al 1989 ;Savard et al 1980 ;Rubinsztein et al 2000 ) and early during the course of the illn...…”

Section: Executive Functionmentioning

confidence: 99%

“…On the other hand, specifi c neurocognitive impairments might be relevant, although further research is needed. There is strong evidence that unaffective relatives of patients occupy an intermediate position between patients and healthy controls concerning specifi c neurocognitive functions (Frantom et al 2008 ).…”

Section: The Neurocognitive Deficit As An Endophenotype For Bdmentioning

confidence: 99%

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Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Fountoulakis

2014

Bipolar Disorder

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Neurocognitive endophenotypes for bipolar disorder

Cited by 79 publications

References 78 publications

Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder

Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder

Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

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