2003
DOI: 10.1192/bjp.182.3.214
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Neurocognitive impairment in drug-free patients with major depressive disorder

Abstract: Pronounced neurocognitive impairment was found in this sample of young adult out-patients with MDD. This is not attributable to the confounding effects of psychotropic medication and could therefore provide an objective marker of brain dysfunction in depression.

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Cited by 449 publications
(289 citation statements)
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“…Patients with major depression also are particularly impaired on verbal learning and episodic memory tasks (Austin et al 1999;Sweeney et al 2000), while implicit memory performances seem spared (Danion et al 1995;Ilsley et al 1995). However, no memory deficit was observed in drug-free major depression (Schatzberg et al 2000;Porter et al 2003). This could suggest that deficits are related to antidepressant medications.…”
Section: Cognitive Deficits In Major Depressionmentioning
confidence: 87%
“…Patients with major depression also are particularly impaired on verbal learning and episodic memory tasks (Austin et al 1999;Sweeney et al 2000), while implicit memory performances seem spared (Danion et al 1995;Ilsley et al 1995). However, no memory deficit was observed in drug-free major depression (Schatzberg et al 2000;Porter et al 2003). This could suggest that deficits are related to antidepressant medications.…”
Section: Cognitive Deficits In Major Depressionmentioning
confidence: 87%
“…Impairment of synaptic plasticity in depression has also been proposed to occur in other telencephalic regions such as the hippocampus. This is evidenced by impairment in declarative memory consolidation (Porter et al, 2003). Together, these deficits in the motor cortex, sensory cortex, and hippocampus suggest a deficiency in facilitatory synaptic plasticity that is widespread and not merely in limbic and frontal regions traditionally considered central to depression.…”
Section: Discussionmentioning
confidence: 99%
“…The finding is significant as one of the first objective demonstrations of impaired neuroplasticity in depression. In this study, a physiological measure of plasticity not confounded by factors such as subjective rating and analysis, subject education levels, practice effects, or motivational factors was used, conferring clear advantages compared with cognitive or other behavioural tests previously used to assess plasticity in depression (Landr et al, 2001;Porter et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
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“…In addition to core symptoms of depression, our CMS model (23) also addressed other clinical aspects highly comorbid with major depression such as anxiety (38) and impaired cognition (39,40). On the other hand, both depression (3-7) and anxiety (41,42) have been linked to impaired GABAergic function and overactive glutamatergic function has been shown in different anxiety disorders (43,44).…”
Section: Regulation Of Glutamate/gaba Cycle and Behaviour By Cms In Wmentioning
confidence: 99%