Neurocognitive Predictors of Treatment Outcomes in Cognitive Processing Therapy for Post-traumatic Stress Disorder: Study Protocol

Cenkner, David P.; Asnaani, Anu; DiChiara, Christina; Harb, Gerlinde C.; Lynch, Kevin G.; Greene, Jennifer L.; Scott, J. Cobb

doi:10.3389/fpsyg.2021.625669

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…The symptoms of PTSD can disappear throughout the patient's life; therefore, they can interfere with work function and life effectiveness [43], [44]. Our findings were in consistency with existing researches.…”

Section: Univariate Analysissupporting

confidence: 91%

Symptoms Description of Family Post Traumatic Stress Disorder of the Mount Merapi Eruption Disaster Victims during Covid19

Wakhid

Hamid

Setiawan

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Volcano disaster can cause psychological problems such as Post Traumatic Stress Disorder (PTSD). PTSD is an anxiety disorder caused by a scary or frightening, unpleasant and challenging event or experience with physical abuse or threatened feeling. AIM: The purpose of this study was to describe the symptoms of PTSD experienced by families after the volcanic eruption disaster in Magelang Regency. METHODOLOGY: This research was conducted with a descriptive-analytic strategy. The research population was community aged 15–64 years, with a total of 574 people, and 86 respondents were selected as samples using a quota sampling technique. RESULTS: The results show that the majority of respondents experience symptoms of PTSD in the mild category as many as 60 respondents with a percentage of 68.9%. However, there are two respondents included in the severe category. The results of this study are expected to be the basis for the community and other institutions to pay attention to the symptoms of PTSD. CONCLUSION: Respondents who are categorized as experiencing weight PTSD symptoms are expected to conduct further examinations at health services immediately; therefore, PTSD can be handled.

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Section: Univariate Analysissupporting

confidence: 91%

Symptoms Description of Family Post Traumatic Stress Disorder of the Mount Merapi Eruption Disaster Victims during Covid19

Wakhid

Hamid

Setiawan

et al. 2022

Open Access Maced J Med Sci

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“…PTSD is a widespread mental disturbance, included in trauma- and stressor-related disorders, which commonly co-occurs with other mental health disorders, such as anxiety ( Brady et al, 2000 ). PTSD evolves from exposure to significant traumatic, frightening, or stressful experiences ( Bracha, 2004 ; Goswami et al, 2013 ; Huang et al, 2020 ; Cenkner et al, 2021 ). Usually, PTSD patients manifest three wide groups of symptoms such as re-experiencing, avoidance, and hyperarousal, and show deficiencies in the processes that lead to the elimination of memories related to intense fear ( Lissek et al, 2005 ; Goswami et al, 2013 ; Inslicht et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Sotalol Treatment may Interfere With Retrieval, Expression, and/or Reconsolidation Processes Thus Disrupting Traumatic Memories in a Post-Traumatic Stress Disorder Mice Model

et al. 2022

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The processes by which fear memory is encoded, consolidated, and re-consolidated are extremely complex and appear to require the release of stress hormones, especially adrenaline (AD). AD improves contextual fear memory, acting specifically on peripheral β2-adrenoceptors. Propranolol (peripheral and central β-adrenoceptor antagonist) treatment was shown to prevent post-traumatic stress disorder (PTSD) development and reduce its symptoms. However, propranolol has several side effects. Thus, we aimed to evaluate if sotalol (a peripheral β-adrenoceptor antagonist) treatment interferes with retrieval, expression, and/or reconsolidation of traumatic memories in a validated mice model that mimics the signs/symptoms of PTSD, thus intending to decrease them. Female mice were induced with PTSD following an established protocol. Sotalol (2.0 mg/kg) or vehicle were administered on days 2, 7, and 14. The percentage of freezing was calculated, and behavioral tests were carried out. Catecholamines in plasma were quantified by HPLC with electrochemical detection. Quantitative real-time polymerase chain reaction (qPCR) was used to evaluate mRNA expression of NR4A family genes in hippocampus. Following the submission of the animals to the same aversive context on days 2, 7, and 14, sotalol-treated mice exhibited significant less freezing behavior. In the elevated plus-maze test, the time spent and number of entries in the open arms, and total arm entries were increased in sotalol-treated mice. Also, the light-dark transition test revealed higher time spent, number of transitions to the light, and total number of transitions in sotalol-treated mice. Moreover, plasma AD was significantly decreased in sotalol-treated mice. On day 14, sotalol-treated mice exhibited a decrease in mRNA expression of Nr4a1 in the hippocampus. In conclusion, in PTSD mice model, sotalol appears to decrease traumatic memories and anxiety-like behavior, probably due to a decrease in peripheral adrenergic activity, which influences traumatic memories. The effects of sotalol upon re-exposure to the traumatic context may be consistent with interference in the retrieval, expression, and/or reconsolidation processes of contextual traumatic memory, resulting in a long-term reduction of PTSD symptoms and signs. The decreased Nr4a1 mRNA expression in the hippocampal formation may be crucial for these mice to develop diminished traumatic contextual memories after sotalol therapy in PTSD.

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Assessment of memory deficits in psychiatric disorders: A systematic literature review

Kushwaha,

Basera,

Kumari

et al. 2024

JNRP

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Memory deficits are observed across psychiatric disorders ranging from the prodrome of psychosis to common mental disorders such as anxiety, depression, and dissociative disorders. Memory deficits among patients recovering from psychiatric disorders could be directly related to the primary illness or secondary to the adverse effect of a treatment such as Electroconvulsive Therapy (ECT). The trouble in the meaningful integration of working-memory and episodic memory is the most commonly affected domain that requires routine assessments. An update on the recent trends of methods of assessment of memory deficits is the first step towards understanding and correcting these deficits to target optimum recovery. A systematic literature search was conducted from October 2018 to October 2022 to review the recent methods of assessment of memory deficits in psychiatric disorders. The definition of ‘Memory deficit’ was operationalized as ‘selective processes of memory, commonly required for activities of daily living, and affected among psychiatric disorders resulting in subjective distress and dysfunction’. We included 110 studies, most of them being conducted in western countries on patients with schizophrenia. Other disorders included dementia and mild cognitive impairment. Brief Assessment of Cognition in Schizophrenia, Cambridge Automated Neuropsychological Test Battery, California Verbal Learning Test, Trail Making Test Part A and B, Rey Auditory Verbal Learning Test, Wechsler Memory Scale, Wechsler Adults Intelligence Scale-IV were the most common neuropsychological assessments used. Mini-Mental State Examination and Montreal Cognitive Assessment were the most common bedside assessment tools used while Squire Subjective Memory Questionnaire was commonly used to measure ECT-related memory deficits. The review highlights the recent developments in the field of assessment of memory deficits in psychiatric disorders. Findings recommend and emphasize routine assessment of memory deficits among psychiatric disorders in developing countries especially severe mental illnesses. It remains interesting to see the role of standardized assessments in diagnostic systems given more than a decade of research on memory deficits in psychiatric disorders.

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Neurocognitive Predictors of Treatment Outcomes in Cognitive Processing Therapy for Post-traumatic Stress Disorder: Study Protocol

Cited by 3 publications

References 62 publications

Symptoms Description of Family Post Traumatic Stress Disorder of the Mount Merapi Eruption Disaster Victims during Covid19

Symptoms Description of Family Post Traumatic Stress Disorder of the Mount Merapi Eruption Disaster Victims during Covid19

Sotalol Treatment may Interfere With Retrieval, Expression, and/or Reconsolidation Processes Thus Disrupting Traumatic Memories in a Post-Traumatic Stress Disorder Mice Model

Assessment of memory deficits in psychiatric disorders: A systematic literature review

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