Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19

Baller, Erica B.; Hogan, Charlotte; Fusunyan, Mark; Ivkovic, Ana; Luccarelli, James; Madva, Elizabeth N.; Nisavic, Mladen; Praschan, Nathan; Quijije, Nadia; Beach, Scott R.; Smith, Felicia A.

doi:10.1016/j.psym.2020.05.013

Cited by 79 publications

(99 citation statements)

References 51 publications

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“…The most common presentation of delirium was mixed, which is the usual presentation in elderly hospitalized patients [21]. Moreover, the rate of agitation seems to be higher in delirium associated with COVID-19, as suggested by other studies [22]. One-quarter of patients with delirium died at the hospital, approximately one week after the onset of delirium, which may indicate that acute confusional states implies a worse prognosis in COVID-19, as described in critically-ill patients [23].…”

Section: Discussionsupporting

confidence: 52%

Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study

et al. 2021

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Section: Discussionsupporting

confidence: 52%

Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study

et al. 2021

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“…One of the recommended models is the one proposed by the Society of Critical Care Medicine (SCCM), which includes management of analgesia, sedation, and delirium care (Barr & Pandharipande, 2013). Through the ICU Liberation initiative, Wesley Ely's group promotes the protocol that includes the following: (Assess): pain prevention and management measures, (Both): evaluation of the state of consciousness, breathing and analgesia-sedation, (Choice): evaluate and prevent Delirium, (Early): mobility and early exercise, (Family): commitment and accompaniment, known as the ABCDEF of delirium (As- sess, Both, Choice, Delirium, Early, Family) (Baller et al, 2020;Ely, 2017;LaHue et al, 2020;Pahlevan et al, 2017;Strijbos, Steunenberg, van der Mast, Inouye, & Schuurmans, 2013). Delirium prevention programs are essential in the era of COVID-19 and should not be omitted, despite the challenges related to the measures established in hospitals, such as, for example, the prohibition of visits to patients, the need to use face masks as well as personal protective equipment (PPE).…”

Section: Non-pharmacological Interventionsmentioning

confidence: 99%

Prevention, diagnosis, and treatment of delirium in older adults with COVID-19. Literature review

et al. 2020

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Background. COVID-19 affects several systems in the body, including the central nervous system (CNS), expressed in the form of headaches, hyposmia, cerebrovascular disease, and neuropathy. Older Adults (OA) are vulnerable to this infection, and may also present delirium, which may be the result of the virus directly affecting the CNS or of systemic inflammation during infection. Objective. To determine the clinical characteristics, risk factors, pathophysiology, treatment measures, and prevention of delirium associated with COVID-19 from a review of the literature in times of the SARS-CoV-2 pandemic. Method. A search was conducted in PubMed, SciELO, UpToDate, and Medscape using keywords in English and Spanish. Results. Seventy-two articles were reviewed. We analyzed inclusion and exclusion criteria and 43 articles with relevant information for the narrative description of the review were selected. Twenty to thirty per cent of the COVID-19 patients will present or develop delirium, or changes in mental status during their hospitalization, with rates of 60% to 70% in severe illness. The exact mechanisms are likely to be multifactorial. There is a worrying lack of attention to the implications of identifying and managing delirium in the response to this pandemic. Discussion and conclusion. Delirium is a frequent neurological manifestation in OA with COVID-19 and requires early identification, as well as the implementation of non-pharmacological and pharmacological treatment strategies, which may reduce the associated morbidity and mortality in this age group.

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“…After invasion, the virus will trigger an inflammatory reaction, create cytokine storm [4], [5], [8], [10], [11], and lead to neuropsychiatric symptoms. Invasion into postrema increases the vulnerability of subjects toward depression and delirium [1], [5], [12]. Virus-induced central nervous system demyelination also occurs.…”

Section: Pathogenesis Of Mental Health Disturbance In Covid-19mentioning

confidence: 99%

“…Virus-induced central nervous system demyelination also occurs. Demyelination occurs due to an inflammatory reaction from molecular mimicry between coronavirus envelope S glycoproteins and myelin [1], [5], [12]. Other causes of mental disorders, including secondary to multiorgan failure, hypoxia, and treatmentrelated [4], [8], [11], [12].…”

Section: Pathogenesis Of Mental Health Disturbance In Covid-19mentioning

confidence: 99%

Coronavirus Disease-2019 and Mental Health

Darmadi

Ruslie

2020

Open Access Maced J Med Sci

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BACKGROUND: Coronavirus disease-2019 (COVID-19) emerges in Wuhan, China and becomes a pandemic on March 2020. Its manifestations mainly cover respiratory and gastrointestinal symptoms. In fact, mental health disorders are common in patients with COVID-19 but receive minimum attention. AIM: We aimed to discuss mental health disturbances in relation to COVID-19 and its management. MATERIALS AND METHODS: We gathered literature regarding the topic from electronic sources, including PubMed and Google Scholar. RESULTS: There are several pathogeneses proposed regarding the incidence of mental health problems. The symptoms of mental health problems vary widely and also affect health-care personnel. Diagnosing mental health problem in COVID-19 patients is quite difficult because no examinations are specific enough. The management of mental health problems includes psychological and medical managements. CONCLUSION: Further study regarding mental health problem and its management in patients with COVID-19 is mandatory.

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Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19

Cited by 79 publications

References 51 publications

Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study

Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study

Prevention, diagnosis, and treatment of delirium in older adults with COVID-19. Literature review

Coronavirus Disease-2019 and Mental Health

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