Neurocytoma arising in the pelvis

Friedrichs, Nicolaus; Vorreuther, R.; Fischer, Hans‐Peter; Wiestler, Otmar D.; Buettner, Reinhard

doi:10.1007/s00428-003-0852-9

Cited by 18 publications

(3 citation statements)

References 10 publications

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“…As a result, there has been no large‐scale study performing genetic analysis of EVN. Only numerous case reports delineating its clinicopathological features have accumulated 4–6,9–31 . Research into the pathogenesis and genetic abnormalities of EVN have been seriously limited.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological and genetic characteristics of extraventricular neurocytomas

Myung

Cho²,

Park³

et al. 2012

Neuropathology

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Extraventricular neurocytoma (EVN) shares histological features with central neurocytoma, but has a wide morphological spectrum. Little is known regarding its clinicopathologic nature, biological behavior and genetic abnormalities. The aim of this study is to examine the diagnostic criteria, genetic abnormalities and biological behavior of EVN. Clinicopathological and molecular genetic studies were performed in seven EVNs. Among them, three cases showed atypical histology. Immunohistochemically, synaptophysin was robustly positive, but neuronal muclear antigen was positive in only half the cases (4/7cases). Isocitrate dehydrogenase enzyme isoform 1 (IDH1) (H09 immunostaining), α-internexin and p53 were negative in all cases. One case was positive for galectin-3. None of the cases showed IDH1 R132 and IDH2 R172 mutation by direct sequencing. One case showed high polysomy of the epidermal growth factor receptor (EGFR) gene; however, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and 1p/19q co-deletion were not detected. Array-based comparative genomic hybridization (CGH) study was performed in two cases, revealing different profiles, with loss and gain of multiple chromosomal loci. Two children (18%) had tumor recurrence after initial surgery, and one of them showed worse histology at recurrence and EGFR high polysomy. One patient died from the disease at 18.5 months after surgery. From our study, we concluded that EVNs were characterized by the absence of p53 overexpression, α-internexin positivity, MGMT promotor methylation and IDH1/IDH2 mutation. Oligodendrocyte transcription factor 2 expression was seen in a scattered positive pattern but quite large numbers of tumor cells were negative. EVN is a WHO grade II tumor but some cases (2/7 cases in our series) can show late recurrence but mortality is low (1/7 cases in our series). CGH study suggested genetic heterogeneity of EVNs and unknown subclassification, which requires verification in more cases.

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Section: Introductionmentioning

confidence: 99%

Clinicopathological and genetic characteristics of extraventricular neurocytomas

Myung

Cho²,

Park³

et al. 2012

Neuropathology

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“…Literature data suggest that the presence of brain tissue in mature teratoma is rare. (21,22,23) Although the HP appearance was highly suggestive for the diagnosis of carcinosarcoma associated with mature teratoma, we performed immunohistochemical testing for confirmation of the mixed character of the malignant proliferation (for the carcinomatous component AE1 / AE3, CA-125, ER, WT1, Although we have no data to prove the existence of a previously asymptomatic ovarian mature teratoma we believe that the coexistence of mature teratoma elements with malignant ones in the peritoneal and ovarian tumor formations support the diagnosis of malignant mature teratoma.…”

Section: Discussion Discussionmentioning

confidence: 99%

Mature Teratoma Associated with Bilateral Ovarian Carcinosarcoma - Accidental Association or Etiopathogenetic Determinism? - Case Report

Bîrlă¹,

Catanescu²,

Caragui³

et al. 2016

chr

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RezumatTeratom matur ovarian bilateral asociat cu carcinosarcom -asociere întâmplãtoare sau determinism etiopatogenic? -prezentare de caz Carcinosarcomul este o forma rarã de cancer ovarian cu origine mixtã, iar asocierea sa cu teratomul matur este extrem de rarã. Prezentãm cazul pacientei T.M. în vârstã de 67 ani, internatã în clinicã în 15.05.2016, F.O. 4877 pentru creaeterea în volum a abdomenului. La internare, pacienta afebrilã, conaetientã, cooperantã, echilibratã cardio-respirator, cu abdomen destins de volum, matitate accentuatã pe flancuri, semnul valului pozitiv, bioumoral în limite normale cu excepåia: acid uric seric = 6.64 mg/dl, glicemie sericã = 113.7 mg/dl, proteine serice totale = 8.65 g/dl, raportul albuminã/globulinã subunitar, CRP 33.63 mg/l, sideremie 51 ug/dl, CA 125 = 588.4 UI. Ecografia abdominalã: cantitate mare de lichid decliv aei perihepatic aei multiple formaåiuni tumorale cu transformare chisticã la nivelul abdomenului aei pelvisului. Examen CT descrie multiple mase tisulare localizate intraperitoneal abdomino-pelvin, manaeonate în epanaeament lichidian, infiltrative, cu efect de masã pe lumenele digestive, fãrã obstrucåie vizibilã CT. Tratamentul chirurgical a constat în evacuarea lichidului de ascitã, excizia formaåiunilor tumorale din marele epiploon, a formaåiunilor tumorale din ligamentul gastro-colic, epiploonectomie, anexectomie bilateralã aei histerectomie totalã. Evoluåie postoperatorie simplã. Examenul histopatologic confirmã diagnosticul de carcinosarcom ovarian bilateral asociat cu teratom matur tridermic (prezenåa zonelor de åesut cerebral, asociat cu åesut cartilaginos, epiteliu de tip tranziåional, epiteliu de tip tubar, stromã de tip endometrial, åesut adipos). IHC confirmã compatibilitatea cu diagnosticul de carcinosarcom ovarian (tumorã malignã mixtã mullerianã). Pacienta a urmat polichimioterapie adjuvantã. Asocierea teratomului cu elemente carcinosarcomatoase conferã cazului un prognostic infaust. Cuvinte cheie: teratom matur, carcinosarcom ovarianAbstract Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113.7 mg / dl, serum total proteins = 8.65 g / dl, the albumin / globulin subunit, CRP 33.63 mg / l, sideremia 51 ug / dl, CA 125 = 588.4 IU. Abdominal ultrasound: high volume fluid and multiple perihepatic formations and multiple formations with cystic Chirurgia (2016) 111: 422-427 No. 5, September -October Copyright© Celsius

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“…A unique case of a central neurocytoma arising within a mature cystic teratoma of the ovary abutted onto an ependyma‐lined cyst within the teratoma and, hence, recapitulated the typical location of neurocytoma adjacent to the lateral ventricle (6). The cells of origin of an exceptional case of neurocytoma arising in the pelvis remain to be identified (5). By contrast, olfactory neurocytoma is a neurogenic tumor which is supposed to take origin from olfactory receptor cells (1).…”

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confidence: 99%