Neurocytoma of the VIIIth Cranial Nerve: Case Report

Öngürü, Önder; Kurtkaya-Yapıcıer, Özlem; Scheithauer, Bernd W.; Luetmer, Patrick H.; Burger, Peter C.; Mann, Sherrie J; Harvey, Steven

doi:10.1227/01.neu.0000179981.62074.b1

Cited by 5 publications

(13 citation statements)

References 24 publications

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“…In addition, they demonstrated that the transition zone of the VIIIth cranial nerve, the point at which the central nervous tissue becomes peripheral, lies a full centimeter more lateral than in other cranial nerves, and it is situated within the internal auditory meatus. In reality, the tumor had obviously occurred at the portion of the VIIIth cranial nerve based on the first operation findings of the present case, which supported the suggestion of Onguru et al …”

Section: Discussionsupporting

confidence: 92%

“…reported a case of pilocytic astrocytoma arising from the proximal trigeminal nerve, completely separate from the brain stem, and they hypothesized that the point of the origin of the tumor was the root entry zone, where nerve axons were supported by neuroglia . Onguru et al ., reported a rare example of an EVN arising in the cochlear‐vestibular portion of the VIIIth cranial nerve resembling the present case . They commented that a similar argument could be made in their case, but consideration should be given to its origin within the transition zone, a reflection of normal development.…”

Section: Discussionsupporting

confidence: 65%

“…Neurocytoma can also occur in brain parenchyma, or even in sites remote from the ventricles. Therefore, the latter tumor was named EVN . Histopathologically, both CN and EVN display uniform, small, round cells with clear cell cytoplasm in a neuropil background .…”

Section: Discussionmentioning

confidence: 99%

“…However, EVN shows a wide variety of histology compared with CN. EVNs can exhibit sheet‐like structures, Homer‐Wright rosettes, and ganglionic differentiation, unlike CN . In addition, EVNs can exhibit hyalinized vessels and myxoid stroma, but CN rarely does so .…”

Section: Discussionmentioning

confidence: 99%

“…CN is a low‐grade neoplasm that is characterized by its intraventricular localization, its occurrence predominantly in young adults, its histological resemblance to oligodendrogliomas, and its expression of neuronal markers . Shortly after the establishment of CN, similar tumors of the central nervous system were reported in several locations outside the supraventricular system as extraventricular neurocytomas (EVNs) . Histologically, EVN is an unusual tumor that is histologically composed of small uniform cells that demonstrate neuronal differentiation.…”

Section: Introductionmentioning

confidence: 99%

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Malignant progression of an extraventricular neurocytoma arising from the VIIIth cranial nerve: A case report and literature review

et al. 2018

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A rare case of extraventricular neurocytoma (EVN) arising from the VIIIth cranial nerve in a 34‐year‐old woman is reported. The patient had a 20‐year history of hearing loss and facial palsy. Computed tomography showed a 3‐cm enhancing lesion in the left cerebellopontine angle (CPA). At operation, the tumor was seen to originate from the cochlear and vestibular nerves. The tumor was subtotally resected. Histologically, the tumor consisted of uniform cells with oval to round nuclei and scant cytoplasm. Immunohistochemically, the tumor cells were positive for synaptophysin, but negative for glial fibrillary acid protein and S‐100 protein. The Ki‐67 labeling index was 0%. Twelve years after the operation, magnetic resonance imaging (MRI) showed tumor recurrence at the left CPA. The tumor was subtotally resected, and radiation therapy was given. Histologically, the tumor consisted of round cells with mild atypia and one mitosis/20 high‐power fields (HPF). Immunohistochemically, tumor cells showed the same findings as the first operation sample, except for the Ki‐67 labeling index (3%). Twelve years after the second operation, MRI showed a second tumor recurrence at the left CPA and surroundings of the brain stem. The tumor was subtotally resected. Histologically, the tumor consisted of anaplastic short spindle cells and five mitoses/10 HPF. The immunohistochemical findings were almost the same as the earlier operation samples. However, the Ki‐67 labeling index was 20%. In addition, tumor cells from the third specimen were more strongly and more diffusely positive for GAB1 (growth factor receptor‐bound protein 2‐associated binding protein 1) compared to those of the earlier specimens. Electron microscopy showed the presence of numerous cell processes with a dense core and clear vesicles and microtubules. GAB1 immunostaining also indicated that malignant progression might be associated with the sonic hedgehog signaling pathways. To the best of our knowledge, this is the first report of an EVN arising from the VIIIth cranial nerve with malignant progression.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Malignant progression of an extraventricular neurocytoma arising from the VIIIth cranial nerve: A case report and literature review

et al. 2018

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Extraventricular Neurocytomas

Sweiss

Lee

Sherman

2015

Neurosurgery Clinics of North America

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Extraventricular neurocytomas (EVNs) are rare neoplasms with many similar morphologic features compared with central neurocytomas. EVNs have been reported in a variety of locations and mainly occur within the cerebral hemispheres. These lesions display wide variability in morphologic features, cellularity, and proliferation rates. In addition, given their aggressive biological nature and tendencies to affect eloquent areas, EVNs are associated with a poorer prognosis. The epidemiology of these rare tumors is not definitively known, and effective treatment strategies have not been developed. This article reviews these tumors, including their epidemiology, clinical presentation, locations, radiological findings, treatment options, and prognosis.

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