Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

Akhtar, Amna; Andleeb, Anisa; Waris, Tayyba Sher; Bazzar, Masoomeh; Moradi, Ali‐Reza; Awan, Nasir; Yar, Muhammad

doi:10.1016/j.jconrel.2020.11.021

Cited by 133 publications

(77 citation statements)

References 102 publications

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“…Effectively, one of the main bottlenecks associated with the development of new therapeutics for PD is the difficulty of many drugs to reach the brain, due to this highly selective semi-permeant barrier that protects brain and the spinal cord from many foreign substances. It is critical the development of deeper investigation studies in more complex in vitro models, such as co-cultures, to understand the ability of C. tomentosum -derived compounds to cross the BBB, and the possibility of their incorporation in smart delivery systems such as nanoparticles for brain drug delivery, tissue engineering, and new biomaterials [ 38 ]. This strategy will contribute to refine the selection of the most active compounds with neuroprotective potential suppressing the gap between in vitro and in vivo assays.…”

Section: Discussionmentioning

confidence: 99%

Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum

et al. 2020

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and is characterized by a progressive degeneration of the dopaminergic neurons in the substantianigra. Although not completely understood, several abnormal cellular events are known to be related with PD progression, such as oxidative stress, mitochondrial dysfunction and apoptosis. Accordingly, the aim of this study was to evaluate the neuroprotective effects of Codium tomentosum enriched fractions in a neurotoxicity model mediated by 6-hydroxydopamine (6-OHDA) on SH-SY5Y human cells, and the disclosure of their mechanisms of action. Additionally, a preliminary chemical screening of the most promising bioactive fractions of C. tomentosum was carried out by GC-MS analysis. Among the tested fractions, four samples exhibited the capacity to revert the neurotoxicity induced by 6-OHDA to values higher or similar to the vitamin E (90.11 ± 3.74% of viable cells). The neuroprotective effects were mediated by the mitigation of reactive oxygen species (ROS) generation, mitochondrial dysfunctions and DNA damage, together with the reduction of Caspase-3 activity. Compounds belonging to different chemical classes, such as terpenes, alcohols, carboxylic acids, aldehydes, esters, ketones, saturated and unsaturated hydrocarbons were tentatively identified by GC-MS. The results show that C. tomentosum is a relevant source of neuroprotective agents, with particular interest for preventive therapeutics.

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Section: Discussionmentioning

confidence: 99%

Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum

et al. 2020

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“…Multiple barriers, including the blood-brain barrier (BBB), blood-CSF barrier, the blood-retinal barrier, and the bloodspinal cord barrier, encircle the CNS without which neural circuits would never be able to play the flute peacefully [66]. However, at the therapeutic level, they are a primary concern for CNS drug delivery.…”

Section: Biomaterials For the Cns And Covid-19: Mechanisms And Implicmentioning

confidence: 99%

“…However, at the therapeutic level, they are a primary concern for CNS drug delivery. There are common approaches to the problem of drug delivery to the brain, including BBB disruption, biotechnology-based delivery, chemistry-based delivery, intracerebral delivery, intrathecal delivery, intranasal delivery, and non-invasive delivery [66], but with the advantages and disadvantages as summarized in Fig. 1.…”

Section: Biomaterials For the Cns And Covid-19: Mechanisms And Implicmentioning

confidence: 99%

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Biosensing surfaces and therapeutic biomaterials for the central nervous system in COVID-19

Saghazadeh

Rezaei

2021

emergent mater.

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COVID-19 can affect the central nervous system (CNS) indirectly by inflammatory mechanisms and even directly enter the CNS. Thereby, COVID-19 can evoke a range of neurosensory conditions belonging to infectious, inflammatory, demyelinating, and degenerative classes. A broad range of non-specific options, including anti-viral agents and anti-inflammatory protocols, is available with varying therapeutic. Due to the high mortality and morbidity in COVID-19–related brain damage, some changes to these general protocols, however, are necessary for ensuring the delivery of therapeutic(s) to the specific components of the CNS to meet their specific requirements. The biomaterials approach permits crossing the blood–brain barrier (BBB) and drug delivery in a more accurate and sustained manner. Beyond the BBB, drugs can protect neural cells, stimulate endogenous stem cells, and induce plasticity more effectively. Biomaterials for cell delivery exist, providing an efficient tool to improve cell retention, survival, differentiation, and integration. This paper will review the potentials of the biomaterials approach for the damaged CNS in COVID-19. It mainly includes biomaterials for promoting synaptic plasticity and modulation of inflammation in the post-stroke brain, extracellular vesicles, exosomes, and conductive biomaterials to facilitate neural regeneration, and artificial nerve conduits for treatment of neuropathies. Also, biosensing surfaces applicable to the first sensory interface between the host and the virus that encourage the generation of accelerated anti-viral immunity theoretically offer hope in solving COVID-19.

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“…Several interrelated cerebral pathways establish the etiopathogenesis of neurodegeneration such as neuroinflammation, altered gene expression, and oxidative stress that eventually could result in the death of neuronal cells [ 1 , 2 ], which are manifested clinically as cognitive dysfunction [ 3 ]. Even if there are available medicines that are used for Alzheimer’s disease, there is a need for more therapies since these medicines do not remedy the whole spectrum of pathobiology [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Edible Bird’s Nest on Cognitive Functions in Experimental Animal Models: A Systematic Review

et al. 2021

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Edible bird’s nest (EBN) is constructed from saliva of swiftlets birds and consumed largely by Southeast and East Asians for its nutritional value and anti-aging properties. Although the neuroprotection of EBN in animals has been reported, there has not been yet systemically summarized. Thus, this review systemically outlined the evidence of the neuroprotective activity of EBN in modulating the cognitive functions of either healthy or with induced-cognitive dysfunction animals as compared to placebos. The related records from 2010 to 2020 were retrieved from PubMed, Scopus, Web of Science and ScienceDirect using pre-specified keywords. The relevant records to the effect of EBN on cognition were selected according to the eligibility criteria and these studies underwent appraisal for the risk of bias. EBN improved the cognitive functions of induced-cognitive dysfunction and enhanced the cognitive performance of healthy animals as well as attenuated the neuroinflammations and neuro-oxidative stress in the hippocampus of these animals. Malaysian EBN could improve the cognitive functions of experimental animals as a treatment in induced cognitive dysfunction, a nutritional cognitive-enhancing agent in offspring and a prophylactic conservative effect on cognition against exposure to subsequent noxious cerebral accidents in a dose-depended manner through attenuating neuroinflammation and neuro-oxidative stress. This systemic review did not proceed meta-analysis.

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Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

Cited by 133 publications

References 102 publications

Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum

Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum

Biosensing surfaces and therapeutic biomaterials for the central nervous system in COVID-19

Efficacy of Edible Bird’s Nest on Cognitive Functions in Experimental Animal Models: A Systematic Review

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