2013
DOI: 10.1016/j.brainres.2013.09.016
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Neurodegenerative Diversity in human cortical contusion: Histological analysis of tissue derived from decompressive craniectomy

Abstract: The principal aim in the management of patients with cerebral contusion (CC) following severe traumatic brain injury (TBI) is the prevention, amelioration, and treatment of secondary neuronal dysfunction and pathology. Distinguishing between irreversibly damaged and surviving tissue could have considerable therapeutic and prognostic implications for patients. To characterize structurally the neuronal compartment of the contused region in samples derived from patients who suffered severe TBI and were subjected … Show more

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Cited by 7 publications
(6 citation statements)
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“…No significant differences were found between counts of supragranular and infragranular regions with antibodies against CRYAB and GFAP. This may indicate that the astroglial reactivity process tends to be homogenous in the injured section, unlike the selective vulnerability of neurons according to the cortical layer seen in TBI ( Riascos et al, 2013 ). It should be noted that for both GFAP and CRYAB labeling, expression was always higher in subcortical white matter than in cortical gray matter, possibly because the number of astrocytes was higher in subcortical white matter.…”
Section: Discussionmentioning
confidence: 99%
“…No significant differences were found between counts of supragranular and infragranular regions with antibodies against CRYAB and GFAP. This may indicate that the astroglial reactivity process tends to be homogenous in the injured section, unlike the selective vulnerability of neurons according to the cortical layer seen in TBI ( Riascos et al, 2013 ). It should be noted that for both GFAP and CRYAB labeling, expression was always higher in subcortical white matter than in cortical gray matter, possibly because the number of astrocytes was higher in subcortical white matter.…”
Section: Discussionmentioning
confidence: 99%
“…Important knowledge has been obtained from both clinical and pre-clinical studies. TBI patients with cerebral contusion and subsequent inflammation are at higher risk for epilepsy than those without contusion [14]. Mechanisms triggered by neuroinflammation such as oxidative stress and mitochondrial dysfunction appear to add to the onset and progression of epilepsy post-TBI and may contribute to the neurodegeneration that has been reported with PTE [15].…”
Section: Introductionmentioning
confidence: 99%
“…Estudios de TCE en humanos han evidenciado alteraciones citomorfológicas en células piramidales de las láminas III y V de la neocorteza cerebral y pérdida de inmunorreactividad de subpoblaciones específicas de interneuronas gabaérgicas positivas para parvalbúmina, como lo son las células en cesta y las células en candelabro. Tanto la pérdida de interneuronas gabaérgicas como sus alteraciones citomorfológicas podrían relacionarse con las alteraciones funcionales observadas en las neuronas piramidales en los biomodelos, como la disminución del control de la actividad eléctrica (14, 16,17).…”
Section: Figuraunclassified