Neurodevelopment for the first three years following prenatal mobile phone use, radio frequency radiation and lead exposure

Choi, Kyung‐Hwa; Ha, Mina; Ha, Eun Hee; Park, Hyesook; Kim, Yangho; Hong, Yun Chul; Lee, Ae-Kyoung; Kwon, Jong Hwa; Choi, Hyung Do; Kim, Nam; Kim, Suejin; Park, Choong-Hee

doi:10.1016/j.envres.2017.04.029

Cited by 26 publications

(25 citation statements)

References 25 publications

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“…Population-based studies have revealed that women exposed to RF-EMF during pregnancy have adverse effects on the neurodevelopment of offspring, and increase their odds of emotional and behavioral difficulties (Sudan et al, 2016;Choi et al, 2017). Studies focus on adolescents students exposed to mobile phones or base stations have revealed that RF-EMF exposure is associated with the impairment of spatial memory, attention deficiency, and delayed motor skills (Foerster et al, 2018;Meo et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Chen

Deng

et al. 2021

Front. Cell Dev. Biol.

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The increasing intensity of environmental radiofrequency electromagnetic fields (RF-EMF) has increased public concern about its health effects. Of particular concern are the influences of RF-EMF exposure on the development of the brain. The mechanisms of how RF-EMF acts on the developing brain are not fully understood. Here, based on high-throughput RNA sequencing techniques, we revealed that transcripts related to neurite development were significantly influenced by 1800 MHz RF-EMF exposure during neuronal differentiation. Exposure to RF-EMF remarkably decreased the total length of neurite and the number of branch points in neural stem cells-derived neurons and retinoic acid-induced Neuro-2A cells. The expression of Eph receptors 5 (EPHA5), which is required for neurite outgrowth, was inhibited remarkably after RF-EMF exposure. Enhancing EPHA5 signaling rescued the inhibitory effects of RF-EMF on neurite outgrowth. Besides, we identified that cAMP-response element-binding protein (CREB) and RhoA were critical downstream factors of EPHA5 signaling in mediating the inhibitory effects of RF-EMF on neurite outgrowth. Together, our finding revealed that RF-EMF exposure impaired neurite outgrowth through EPHA5 signaling. This finding explored the effects and key mechanisms of how RF-EMF exposure impaired neurite outgrowth and also provided a new clue to understanding the influences of RF-EMF on brain development.

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Section: Introductionmentioning

confidence: 99%

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Chen

Deng

et al. 2021

Front. Cell Dev. Biol.

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“…This, and a limited number of other mammal-based studies [5] suggest that developmental exposures to RFR can result in adverse effects. However, there also exists evidence to the contrary, with several epidemiological studies suggesting a lack of effects unequivocally attributable to RFR exposure [12]. Most of the published RFR studies are based on previous generations of telecommunication RFRs.…”

Section: Introductionmentioning

confidence: 99%

Impacts of high dose 3.5 GHz cellphone radiofrequency on zebrafish embryonic development

et al. 2020

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The rapid deployment of 5G spectrum by the telecommunication industry is intended to promote better connectivity and data integration among various industries. However, since exposures to radio frequency radiations (RFR) >2.4 GHz are still uncommon, concerns about their potential health impacts are ongoing. In this study, we used the embryonic zebrafish model to assess the impacts of a 3.5 GHz RFR on biology-a frequency typically used by 5G-enabled cell phones and lies within the 4G and 5G bandwidth. We established a plate-based exposure setup for RFRs, exposed developing zebrafish to 3.5 GHz RFR, specific absorption rate (SAR) � 8.27 W/Kg from 6 h post fertilization (hpf) to 48 hpf, and measured a battery of morphological and behavioral endpoints at 120 hpf. Our results revealed no significant impacts on mortality, morphology or photomotor response and a modest inhibition of startle response suggesting some levels of sensorimotor disruptions. This suggests that the cell phone radiations at low GHz-level frequencies are likely benign, with subtle sensorimotor effects. Through this assessment, we have established a robust setup for zebrafish RFR exposures readily amenable to testing various powers and frequencies. Future developmental exposure studies in zebrafish will evaluate a wider portion of the radio frequency spectrum to discover the bioactive regions, the potential molecular targets of RFR and the potential long-term effects on adult behavior.

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“…17 Interestingly, there is no study to date that can confirm any of these hypotheses. 7 Wired-in hands-free kits (HFKs) can considerably reduce RFR exposure to the head, 18 which is inconsistent with the results of Sudan et al, 13 that found that the use of a handsfree device during pregnancy was associated with the increased risk. The highest ORs for migraines were found in the groups that often used hands-free devices, followed by those who "rarely used hands-free devices" and "never used hands-free devices."…”

Section: Discussionmentioning

confidence: 97%

Can Prenatal and Postnatal Cell Phone Exposure Increase Adverse Maternal, Infant and Child Outcomes?

Ashrafinia

Moeindarbari

Razmjouei

et al. 2021

Rev Bras Ginecol Obstet

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Objective To determine the association between maternal mobile phone use and adverse outcomes in infants, children, and mothers. Method In March 202, we conducted a search on the MEDLINE, Embase, and Scopus databases. Data extraction and an assessment of the quality of the studies were performed by two authors. The quality of the studies was assessed using the checklist of the Newcastle-Ottawa scale. Results Studies assessing behavioral problems in infants aged 6 to 18 months reported null findings. However, an increased risk of emotional and behavioral disorders was observed in children aged between 7 and 11 years whose mothers had been exposed to cell phones. The findings regarding the association between maternal cell phone exposure and adverse outcomes in children aged 3 to 5 are controversial. A study found a significant association between the call time (p = 0.002) or the history of mobile phone use (in months) and speech disorders in the children (p = 0.003). However, another study found that maternal cell phone use during pregnancy was not significantly associated with child psychomotor and mental developments. Inconclusive results were observed about the adverse outcomes in fetuses, such as fetal growth restriction or t scores for birth weight in cell phone users as opposed to non-users. On the contrary, the children of mothers who were cell phone users had a lower risk of scoring low on motor skills. Similar results were observed regarding the adverse outcomes of cell phone use in infants, such as fetal growth restriction or low birth weight, and the risk of preeclampsia was lower among subjects with medium and high cell phone exposure, as opposed to those with low exposure. Conclusion Studies on behavioral problems have reported different postnatal results, such as null findings among infants and a positive association in children.

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Neurodevelopment for the first three years following prenatal mobile phone use, radio frequency radiation and lead exposure

Abstract: We found no association between prenatal exposure to RFR and child neurodevelopment during the first three years of life; however, a potential combined effect of prenatal exposure to lead and mobile phone use was suggested.

Cited by 26 publications

References 25 publications

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Impacts of high dose 3.5 GHz cellphone radiofrequency on zebrafish embryonic development

Can Prenatal and Postnatal Cell Phone Exposure Increase Adverse Maternal, Infant and Child Outcomes?

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