Neurodevelopmental Effects of Mercury

Oliveira, Cláudia S.; Nogara, Pablo Andrei; Ardisson-Araújo, Daniel Mendes Pereira; Aschner, Michael; Rocha, João Batista Teixeira da; Dórea, José G.

doi:10.1016/bs.ant.2018.03.005

Cited by 33 publications

(23 citation statements)

References 283 publications

(235 reference statements)

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“…In all forms, mercury is a pollutant of global concern because of its negative effects on human health across the globe. The state of knowledge concerning mercury toxicity and the human health effects has been extensively reviewed (see WHO 2007WHO , 2008USATSDR 1999;Oliveira et al 2018). The brain and central nervous system are the main target tissues for the effects of mercury in adult population as well as in neonates, infants, and children.…”

Section: Mercurymentioning

confidence: 99%

Global Impact of Chemicals and Toxic Substances on Human Health and the Environment

Adeola¹

2020

Handbook of Global Health

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This chapter addresses the global impacts of heterogenous chemicals and toxic substances on human health and the environment. Chemicals and hazardous substances are ubiquitous in every nook and cranny of society across the globe. The challenges facing the scientific community in documenting the number and variety of chemicals, and hazardous products that are manufactured, available on the market, and in use as well as the disease burden associated with them are discussed. The chapter addresses the chemicals, hazardous substances of global public health concern, including air pollution, inorganic substances especially heavy metals, and synthetic organic compounds such as the Persistent Organic Pollutants (POPs) and pesticides. Gaseous elements, acids and bases are also covered. Major sources of releases into the environment and routes of exposure and the consequences for exposed population's health and well-being are addressed. The estimated Global Burden of Disease (GBD), Disability Adjusted Life Years (DALYs), and economic loss associated with selected chemical

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Section: Mercurymentioning

confidence: 99%

Global Impact of Chemicals and Toxic Substances on Human Health and the Environment

Adeola¹

2020

Handbook of Global Health

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“…Mercury is abundant in the earth’s crust and is mobilised into the environment through human industrial activity and natural events such as volcanic activity [ 11 , 12 , 13 ]. Routes to human contact are well documented [ 13 , 14 , 15 ], and include the food chain, soil, water contamination, and mercury-containing cosmetics and other goods [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, inorganic mercury when ingested tends to accumulate within the kidneys and can also be formed within the body from oxidised elemental mercury. Both forms are highly reactive with sulphur-containing proteins and can deactivate enzymes, inhibit DNA methylation and cell division, and lead to oxidative stress and cell death [ 14 , 17 ]. Methylmercury (MeHg)—an organic compound bound with carbon—is the most bioavailable form of mercury and can easily enter the body through the digestion of contaminated foods [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Mercury and Prenatal Growth: A Systematic Review

Dack

Fell

Taylor

et al. 2021

IJERPH

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The intrauterine environment is critical for healthy prenatal growth and affects neonatal survival and later health. Mercury is a toxic metal which can freely cross the placenta and disrupt a wide range of cellular processes. Many observational studies have investigated mercury exposure and prenatal growth, but no prior review has synthesised this evidence. Four relevant publication databases (Embase, MEDLINE/PubMed, PsycINFO, and Scopus) were systematically searched to identify studies of prenatal mercury exposure and birth weight, birth length, or head circumference. Study quality was assessed using the NIH Quality Assessment Tool, and results synthesised in a narrative review. Twenty-seven studies met the review criteria, these were in 17 countries and used 8 types of mercury biomarker. Studies of birth weight (total = 27) involving populations with high levels of mercury exposure, non-linear methods, or identified as high quality were more likely to report an association with mercury, but overall results were inconsistent. Most studies reported no strong evidence of association between mercury and birth length (n = 14) or head circumference (n = 14). Overall, our review did not identify strong evidence that mercury exposure leads to impaired prenatal growth, although there was some evidence of a negative association of mercury with birth weight.

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“…A decreased mercury burden in liver, kidney, cerebrum and cerebellum of mouse was reported in mice treated with (PhSe)2 [3,4,9]. We have hypothesized that (PhSe)2 could be reduced to its selenol intermediate PhSeH, which formed a complex with MeHg + (i.e., PhSeHgMe) [5,9,10]. The reduction of (PhSe)2 and its eventual reaction with methylmercury have several intricate and interesting parts, as reactions may eventually depend on the conformation assumed by (PhSe)2 in the reacting medium [11][12][13].…”

Section: Introductionmentioning

confidence: 99%