Neuroendocrine aspects of migraine in women

Nappi, Rossella E.; Nappi, Giuseppe

doi:10.3109/09513590.2012.651931

Cited by 20 publications

(10 citation statements)

References 56 publications

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“…Migraine, common in the general population, is more prevalent in women [Nappi and Nappi, ]. Migraine is also more prevalent among EDS which also has a female predilection [Bendik et al, ; Castori and Voermans, ; Castori et al, ].…”

Section: Headache In Ehlers–danlos Syndromementioning

confidence: 99%

Neurological and spinal manifestations of the Ehlers–Danlos syndromes

Henderson¹,

Austin²,

Benzel³

et al. 2017

American J of Med Genetics Pt C

182

174

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The Ehlers–Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression. This report also discusses increased prevalence of migraine, idiopathic intracranial hypertension, Tarlov cysts, tethered cord syndrome, and dystonia, where associations with EDS have been anecdotally reported, but where epidemiological evidence is not yet available. Chiari Malformation Type I (CMI) has been reported to be a comorbid condition to EDS, and may be complicated by craniocervical instability or basilar invagination. Motor delay, headache, and quadriparesis have been attributed to ligamentous laxity and instability at the atlanto‐occipital and atlantoaxial joints, which may complicate all forms of EDS. Discopathy and early degenerative spondylotic disease manifest by spinal segmental instability and kyphosis, rendering EDS patients prone to mechanical pain, and myelopathy. Musculoskeletal pain starts early, is chronic and debilitating, and the neuromuscular disease of EDS manifests symptomatically with weakness, myalgia, easy fatigability, limited walking, reduction of vibration sense, and mild impairment of mobility and daily activities. Consensus criteria and clinical practice guidelines, based upon stronger epidemiological and pathophysiological evidence, are needed to refine diagnosis and treatment of the various neurological and spinal manifestations of EDS. © 2017 Wiley Periodicals, Inc.

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Section: Headache In Ehlers–danlos Syndromementioning

confidence: 99%

Neurological and spinal manifestations of the Ehlers–Danlos syndromes

Henderson¹,

Austin²,

Benzel³

et al. 2017

American J of Med Genetics Pt C

182

174

View full text Add to dashboard Cite

show abstract

“…In the adult brain , women are more affected by migraine than men, and neuroendocrine drivers are thought to act as major modulators (33). In the 2011 National Health Interview Survey, 16.6% of adults > 18 years reported having migraine or other severe headaches in the last 3 months, and the prevalence was shown to be highest in females 18-44 years and lowest in males >75 years (34).…”

Section: Phenotypic Expression By Physiological Modulators In the Devmentioning

confidence: 99%

Sex and the migraine brain

Borsook

Erpelding

Lebel

et al. 2014

Neurobiology of Disease

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The brain responds differently to environmental and internal signals that relates to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.

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“…In addition, there is disagreement about migraine prophylaxis medications for these patients [7]. There are several biological theories about the cause of PMS [8][9][10][11]. It seems that there is a consensus that natural fluctuations in gonadal hormones (estrogen and progesterone) in women who are vulnerable to developing migraines can lead to the biochemical changes in the brain which are responsible for PMS symptoms.…”

Section: Migraine In Premenstrual Syndrome;mentioning

confidence: 99%

“…It seems that there is a consensus that natural fluctuations in gonadal hormones (estrogen and progesterone) in women who are vulnerable to developing migraines can lead to the biochemical changes in the brain which are responsible for PMS symptoms. Fluctuations in estrogen levels lead to increased cerebrovascular stimulation and cause headache [7][8][9][10][11][12]. It seems that among all neurotransmitters studied until now, serotonin is more related to PMS than others.…”

Section: Migraine In Premenstrual Syndrome;mentioning

confidence: 99%