Sex and the migraine brain

Borsook, David; Erpelding, Nathalie; Lebel, Alyssa; Linnman, Clas; Veggeberg, Rosanna; Grant, P. Ellen; Buettner, Catherine; Becerra, Lino; Burstein, Rami

doi:10.1016/j.nbd.2014.03.008

Cited by 86 publications

(56 citation statements)

References 216 publications

(206 reference statements)

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“…These data seem worthy of confirmation in larger samples. Another observation, which may emerge from these data, regards the equilibrium between sexes in the observed population, which confirms the results of epidemiological studies in prepubertal children [34–36]. As expected, the disability linked with migraine prevailed in the CM group.…”

Section: Discussionsupporting

confidence: 88%

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Tommaso

Sciruicchio²,

Delussi

et al. 2017

J Headache Pain

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Background: Central sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This study aimed to evaluate the frequency and the clinical characteristics of allodynia, pericranial tenderness, and comorbidity for Juvenile Fibromialgia (JFM) in a cohort of migraine children selected in a tertiary headache center. Methods: This was an observational cross-sectional study on 8-15 years old migraine patients. Allodynia was assessed by a questionnaire. Pericranial tenderness and comorbidity for JFM as well as their possible association with poor quality of life and migraine related disability, and with other clinical symptoms as anxiety, depression, sleep disorders and pain catastrophizing, were also evaluated. Results: One hundred and fifty one patients were selected, including chronic migraine (n°47), migraine without aura (n°92) and migraine with aura (n°12) sufferers. Allodynia was reported in the 96,6% and pericranial tenderness was observed in the 68.8% of patients. Pericranial tenderness was more severe in patients with more frequent migraine and shorter sleep duration. Allodynia seemed associated with anxiety, pain catastrophizing and high disability scores. Comorbidity for JFM was present in the 0.03% ofpatients. These children presented with a severe depression and a significant reduction of quality of life as compared to the other patients. Conclusions: This study outlined a relevant presence of symptoms of central sensitization among children with migraine. Severe allodynia and comorbidity for JFM seemed to cause a general decline of quality of life, which would suggest the opportunity of a routine assessment of these clinical features.

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Section: Discussionsupporting

confidence: 88%

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Tommaso

Sciruicchio²,

Delussi

et al. 2017

J Headache Pain

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“…Sex-related changes in women may result from an innate genetic or epigenetic process in female migraineurs. Alternatively it may relate to sex related hormonal changes that may result in the observed prevalence [31]. …”

Section: Introductionmentioning

confidence: 99%

Female migraineurs show lack of insular thinning with age

Maleki

Barmettler

Moulton

et al. 2015

Pain

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Gray matter loss in cortical regions is a normal ageing process for the healthy brain. There have been few studies on the process of ageing of the brain in chronic neurological disorders. In this study, we evaluated changes in the cortical thickness by age in 92 female subjects (46 migraine patients, and 46 healthy controls) using high field MRI. The results indicate that in contrast to healthy subjects migraineurs show lack of thinning in the insula by age. The functional significance of the lack of thinning is unknown, but may contribute to the overall cortical hyperexcitability of the migraine brain since the region is tightly involved in a number of majo brain networks involved in interoception, salience, nociception, and autonomic function, including the default mode network.

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“…In addition, women report more migraine-related symptoms and greater impairment compared to male migraineurs [51]. These data have led some researchers to suggest a putative role of female sex hormones in prevalence and clinical expression of migraine [53]. These sex-specific differences in prevalence and symptomatology are still poorly understood and have driven neuroimaging research to investigate changes in brain structure and function between male and female migraine patients-possibly indicating a sex-specific phenotype ( Table 2).…”

Section: Sex-specific Differences In Migrainementioning

confidence: 99%

Migraine: What Imaging Reveals

Chong

Schwedt

Dodick

2016

Curr Neurol Neurosci Rep

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Although migraine symptomatology is well-defined, our understanding of migraine pathophysiology is incomplete. Structural and functional brain imaging can contribute to a greater understanding of migraine pathophysiology. Recent neuroimaging studies demonstrate that migraine is associated with structural and functional alterations of brain regions commonly implicated in pain processing. This review summarizes recent brain structural and functional imaging findings in migraine and highlights those that are associated with characteristics such as the presence or absence of aura, associated cognitive dysfunction, sex-differences (male vs. female migraineurs), age, and disease burden.

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Sex and the migraine brain

Cited by 86 publications

References 216 publications

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Female migraineurs show lack of insular thinning with age

Migraine: What Imaging Reveals

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