Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy

Akgör, Utku; Kuru, Oğuzhan; Sakıncı, Mehmet; Boyraz, Gökhan; Sen, Serhat; Çakır, İlker; Turan, Taner; Gökçü, Mehmet; Gültekin, Murat; Sayhan, Sevil; Salman, Coskun; Özgül, Nejat

doi:10.1016/j.jogoh.2020.101897

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…Endometrial cancer is often diagnosed in its early stages due to early clinical signs because of abnormal uterine bleeding. However, ENC is a highly aggressive malignant endometrial cancer, which is generally diagnosed at an advanced stage 2,4 . Our data demonstrated that the median survival time of ENC was significantly lower than EAC, ESC, ECC, and EMC.…”

Section: Discussionmentioning

confidence: 62%

“…However, ENC is a highly aggressive malignant endometrial cancer, which is generally diagnosed at an advanced stage. 2,4 Our data demonstrated that the median survival time of ENC was significantly lower than EAC, ESC, ECC, and EMC. Two-year survival of ENC was only 28% with 5-year survival of only 23%.…”

Section: Discussionmentioning

confidence: 72%

“…2 The clinical manifestations of ENC are usually abnormal uterine bleeding or symptomatic metastasis. 4 Due to the extremely low incidence of ENC, there are few literatures available, which were mainly retrospective studies with small sample sizes or individual case reports. 4,5 The epidemiological information and accurate recommendations for ENC are still limited, which is not enough for accurate clinical diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

“…4 Due to the extremely low incidence of ENC, there are few literatures available, which were mainly retrospective studies with small sample sizes or individual case reports. 4,5 The epidemiological information and accurate recommendations for ENC are still limited, which is not enough for accurate clinical diagnosis and treatment. Therefore, this study collected 171 cases of ENC from SEER (surveillance, epidemiology, and end results) database for 30 years from 1987 to 2016 to summarize and analysis the clinical characteristics of ENC.…”

Section: Introductionmentioning

confidence: 99%

“…The reported median survival time was 17 months (95% confidence interval [CI], 12–23) 2 . The clinical manifestations of ENC are usually abnormal uterine bleeding or symptomatic metastasis 4 …”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristic and prognostic factors in high‐grade endometrial neuroendocrine carcinoma

Zhang

Wang

et al. 2022

J of Obstet and Gynaecol

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Aim:The aim of the present study was to summarize the clinical characteristics and analyze the independent prognostic factors in patients with high-grade endometrial neuroendocrine carcinoma (ENC). Methods: Patients diagnosed with ENC, endometrioid adenocarcinoma (EAC), endometrial clear-cell carcinoma (ECC), endometrial serous carcinoma (ESC), endometrioid carcinoma with mucinous features (EMC) from 1987 to 2016 were screened from the National Cancer Institute database (surveillance, epidemiology, and end results [SEER]). Kaplan-Meier were used to assess survival. Univariate and multivariate Cox proportional hazards analysis were done to examine factors affecting survival. Results: The median survival times of ENC were 11 months, shorter than that of EAC, ECC, ESC, and EMC (p < 0.01). There was no significant difference in ages, survival rate, and median survival time between largecell ENC (LCENC) and small-cell ENC (SCENC), which were all belong to ENC. In a multivariable model, the hazard ratio (HR) of death for women with Federation International of Gynecology and Obstetrics (FIGO) stage I-II of ENC was 0.37 compared to FIGO stage III-IV (p < 0.01). The HR of patients who under the surgery was 0.39 compared to the patients who without surgery (p < 0.01), and the HR of patients who received chemotherapy was 0.51 compared to the patients who did not received chemotherapy (p < 0.01). Radiotherapy did not significantly reduce the mortality risk of patients. Conclusion: ENC was a kind of devastating endometrial cancers with the poorest prognosis. Surgical treatment and chemotherapy were necessary for improving prognosis of ENC. Early diagnosis favored better prognosis. There was no prognostic difference between with and without radiotherapy.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristic and prognostic factors in high‐grade endometrial neuroendocrine carcinoma

Zhang

Wang

et al. 2022

J of Obstet and Gynaecol

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Small‐cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Saraei,

Heshmati,

Hosseini

2024

J Neuroendocrinology

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Small‐cell neuroendocrine carcinomas (SCNECs) of the female genital tract are rare and aggressive tumors that are characterized by a high rate of recurrence and poor prognosis. They can arise from various sites within the female genital tract, including the cervix, endometrium, ovary, fallopian tube, vagina, and vulva. They are composed of cells with neuroendocrine features, such as the ability to produce and secrete hormones and peptides, and a high mitotic rate. Immunohistochemical staining for neuroendocrine markers, such as chromogranin A, synaptophysin, and CD56, can aid in the diagnosis of these tumors. This article provides an overview of the epidemiology, etiology, and risk factors associated with these tumors, as well as their clinical presentation, cellular characteristics, diagnosis, and finally the current treatment options for SCNECs, including surgery, chemotherapy, and radiation therapy, alone or in combination.

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Combined Carcinoid Carcinoma and Squamous Cell Carcinoma of the Endometrium: A Case Report and Survey of Related Literature

Han,

Zhang,

Niu

et al. 2023

Case Rep Oncol

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Introduction: Histologically, endometrial neuroendocrine carcinoma is an extremely rare pathological type of endometrial cancer. In addition, this type is characterized by high invasiveness and poor clinical outcome, which was classified into carcinoid (low grade), and small-cell and large-cell neuroendocrine carcinoma (high grade). Globally, reports on endometrial carcinoid carcinoma are limited. Clinically, it is also rare to see primary squamous cell carcinoma of endometrium. Case Presentation: Here, we report an interesting case of mixed carcinoma of endometrium with both carcinoid and squamous cell carcinoma, which presented with persistent vaginal bleeding and hyponatremia. Conclusion: Careful pathologic review is necessary to diagnose this rare disease. More studies in the future are warranted to demonstrate the primary surgical treatments and the efficacy of adjuvant therapy of this disease.

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Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy

Cited by 8 publications

References 18 publications

Clinical characteristic and prognostic factors in high‐grade endometrial neuroendocrine carcinoma

Clinical characteristic and prognostic factors in high‐grade endometrial neuroendocrine carcinoma

Small‐cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Combined Carcinoid Carcinoma and Squamous Cell Carcinoma of the Endometrium: A Case Report and Survey of Related Literature

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