Neuroendocrine Carcinoma of the Uterine Cervix: A Clinicopathologic Retrospective Study of 31 Cases with Prognostic Implications

Abstract

The present study describes 31 clinical cases of neuroendocrine cervical carcinoma (NECC) treated at Mackay Memorial Hospital between January 1, 1991 and October 31, 2003. There are two cases of atypical carcinoid tumor (ACT), four cases of large-cell neuroendocrine carcinoma (LCNEC), and 25 cases of small-cell neuroendocrine carcinoma (SCNEC). Overall survival did not differ significantly in relation to surgery, tumor histology, age, FIGO stages, chemotherapeutic regimens or lymph node involvement. The specimens available did not permit HPV (human papillomavirus)-DNA analysis in 5 cases (5/31, 9.7%). The HPV viral infection was absent in 8 cases (8/31, 26%); 17 cases of HPV-18 (17/31); and 1 case of HPV-16 (1/31). The prognosis between mixed and pure type histologic patterns is not significant. The mean survival time for all patients was 32.3 months. The 2-year and 5-year survival rates were 54.8% and 31.5% for all patients. The results of this study reaffirm the biologically aggressive nature of this rare malignancy, its low survival rate, and its very unpredictable prognostic factors. Effective treatments of neuroendocrine cervical tumor still remain inconclusive. Further efforts are still required to identify prognostic factors for this uncommon disease.

HPV-Related Squamous Cell Carcinoma Variants in the Head and Neck

“…The majority of HPV-related SCC of the oropharynx exhibits a characteristic microscopic appearance, typically a non-keratinizing squamous cell morphology [31][32][33]. The neoplastic cells show an immature basaloid appearance and are mitotically active.…”

“…Both are associated with high-risk HPV, commonly coexist with non-small cell squamous cell carcinoma, and share the same aggressive clinical behavior with early distant metastasis and poor OS [27,28,30,31].…”

Prognostic factors in FIGO stage IB–IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: results of a multi-center retrospective Korean study

“…We therefore carried out a retrospective multicenter trial to identify the clinical and pathologic factors prognostic of survival, and to determine optimal treatment strategies for patients with early stage SCNEC. Table 3 is a review of literature published until a recent date for SCNEC [3,5,[10][11][12][13][14][15][16][17]. Large tumor size, lymph node metastases, smoking, stage, deep stromal invasion and a pure histologic type have been indicated as possible poor prognostic factors [3-5, 10, 12, 13, 18].…”

Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

“…Available evidences based on only a constrained number of NECA cases demonstrate that almost all of NECA cases are associated with HPV 16 and/or HPV 18. However, in contrast to that noted in SCCA, the most prevalent HPV type among NECA cases is HPV 18, followed by HPV 16 (Masumoto et al, 2003;Ishida et al, 2004;Wang et al, 2006). In a study from Northern Thailand which is the largest study conducted to determine HPV genotype distribution in NECA, almost 90% of cases of NECA are HPV 16 and/or HPV 18-related.…”