Neuroendocrine Dysfunction in PCOS: A Critique of Recent Reviews

Doi, Suhail A.R.

doi:10.3121/cmr.2008.796

Cited by 23 publications

(18 citation statements)

References 73 publications

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“…Although elevated A4 levels are a frequent finding among women with PCOS, it is not often considered a main diagnostic criterion of biochemical HA. DHEAS, DHEA and A4 are all precursors of testosterone . In severe PCOS phenotypes, circulating A4 levels may be increased, making it a valuable marker to assess biochemical HA; A4 and DHEAS are of both adrenal and ovarian origin; therefore, the existence any positive associations between FG score and these parameters can represent an adrenal disorder.…”

Section: Discussionmentioning

confidence: 99%

Association between biochemical hyperandrogenism parameters and Ferriman‐Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta‐regression analysis

Amiri

Tehrani

Nahidi

et al. 2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

Association between biochemical hyperandrogenism parameters and Ferriman‐Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta‐regression analysis

Amiri

Tehrani

Nahidi

et al. 2017

Clinical Endocrinology

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“…The clutter in the release of gonadotropins: luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary have been implicated in the pathogenesis of PCOS. In almost patients with PCOS, the relation of LH/FSH is altered, being higher the LH secretion in relation to FSH, resulting in an increased production of androgens by theca cells, and anovulatory cycles [18] [19]. However, more recent studies have shown that these changes in LH levels are a secondary event and non-primary [19].…”

Section: Abnormalities In Pituitary Functionmentioning

confidence: 99%

Polycystic Ovary Syndrome (PCOS) and Fertility

Barbosa¹,

Sá²,

Rocha³

et al. 2016

OJEMD

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The polycystic ovary syndrome (PCOS) is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhea, infertility, and dysfunctional uterine bleeding), with or without the presence of polycystic ovaries on ultrasound. It represents the main endocrine disorder in the reproductive age, affecting 6% -15% of women in menacme. It is the most common cause of infertility due to anovulation, and the main source of female infertility. When in the presence of a menstrual disorder, the diagnosis of PCOS is reached in 30% -40% of patients with primary or secondary amenorrhoea and in 80% of patients with oligomenorrhea. PCOS should be diagnosed and treated early in adolescence due to reproductive, metabolic and oncological complications which may be associated with it. Treatment options include drugs, diet and lifestyle improvement.

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“…Many studies have revealed that increase in testosterone levels disturbs the gonadotropin-releasing hormone secretion which, in turn, affects the release of sex hormones such as progesterone and estrogen [23,24]. For the maintenance of implantation of blastocyst and pregnancy in humans and other mammals, the sex hormones such as progesterone and estrogen are the most important hormones [25,26].…”

Section: Discussionmentioning

confidence: 99%

Effect of Sargassum Ilicifolium on Ovogenesis in Pcos Induced Rats

Anbu

Krishnan

Shivalingappa

et al. 2016

Asian J Pharm Clin Res

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Objective: This study was conducted to evaluate the effect of Sargassum ilicifolium on testosterone-induced polycystic ovary syndrome (PCOS) in rats.Methods: Female Wistar albino rats were divided into 6 groups consisting of 6 rats each. PCOS was induced in all the animals except normal group on the administration of testosterone (2 mg/100 g) for 21 days daily. After PCOS induction, the standard group rats were treated with clomiphene citrate (CC) (1 mg/kg. p.o.). The test groups were treated with 100, 200, and 400 mg/kg of ethanolic extract of S. ilicifolium orally, and normal animals were administered 2% carboxymethyl cellulose (2 ml/kg), respectively, for 21 days during induction and treatment period various parameters such as estrus cycle, histopathology, hormonal, and biochemical assays have been evaluated. Further to confirm the enhanced fertility rate, the rats were mated, and the litter size was observed. Results:The results revealed the normalcy in estrus cycle, hormonal, biochemical, and histopathological parameters. The litter size was increased significantly compared to control. Conclusion:Overall, from the obtained results, it is determined that the S. ilicifolium exhibited a good antiandrogenic effect by reducing the testosterone levels in PCOS-induced conditions.

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Neuroendocrine Dysfunction in PCOS: A Critique of Recent Reviews

Cited by 23 publications

References 73 publications

Association between biochemical hyperandrogenism parameters and Ferriman‐Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta‐regression analysis

Association between biochemical hyperandrogenism parameters and Ferriman‐Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta‐regression analysis

Polycystic Ovary Syndrome (PCOS) and Fertility

Effect of Sargassum Ilicifolium on Ovogenesis in Pcos Induced Rats

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