Neuroendocrine hemisphere asymmetries: Salivary cortisol secretion during lateralized viewing of emotion-related and neutral films

Wittling, Werner; Pflüger, Markus

doi:10.1016/0278-2626(90)90032-j

Cited by 124 publications

(66 citation statements)

References 36 publications

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“…For example, research with young rhesus monkeys indicates that high levels of circulating cortisol are associated with fearful behavior and high right-frontal activity (Kalin et al 1998). This finding is consistent with results from human studies showing a preferential role for the right-hemisphere in emotion-induced cortisol release (Wittling and Pfluger 1990; also see Henry 1993) and further supports the view that neonatal stress and its physiological consequences influence the emergence of hemispheric specialization.…”

supporting

confidence: 90%

Hormonal Correlates of Hand Preference in Free-ranging Primates

Westergaard¹,

Chavanne²,

Lussier³

et al. 2000

Neuropsychopharmacology

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supporting

confidence: 90%

Hormonal Correlates of Hand Preference in Free-ranging Primates

Westergaard¹,

Chavanne²,

Lussier³

et al. 2000

Neuropsychopharmacology

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“…In fact there is some evidence supporting this possibility. 28,29 Obesity is not a homogeneous condition and the term obesities' should probably be used instead. 41,42 Comparisons between normal and overweight subjects may therefore be considered as preliminary.…”

Section: Discussionmentioning

confidence: 99%

“…30 Since parental obesity was not a signi®cant factor for cerebral asymmetry, this more probably suggests that neural axis asymmetry may play a developmental in¯uence on obesity acquisition, as has been proposed by others. 29,50 CRH testing resulted in a large ACTH response with a minor, albeit signi®cant cortisol response. Crudely, this kind of response agrees well with previous reports.…”

Section: ± 43mentioning

confidence: 99%

“…Particularly to the point, emotions are clearly lateralized, one example being the vegetative and endocrine component of emotive expression. 28,29 Given the central control of the endocrine function and in particular of the HPA axis, it is possible that the asymmetry would also be apparent at this level, and contribute to individual variability. The same asymmetry may also be relevant in the pathogenesis of weight gain, since visceral sensation is postulated to be operant in the control of eating behaviour.…”

Section: Introductionmentioning

confidence: 99%

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Psychoneuroendocrine characteristics of common obesity clinical subtypes

et al. 2001

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OBJECTIVE: To relate psychological pro®les, cerebral asymmetry and the hypothalamus ± pituitary ± adrenal axis (HPA) reactivity to clinical characteristics of common obesity. METHODS: Sixty consecutive adult female overweight and obese patients attending the outpatient endocrine department were included in this study. Clinical evaluation speci®cally selected a priori the following indexes: obesity age of onset, parenthood obesity, carbohydrate craving, binge eating with purging, obesity degree (de®ned by the body mass index (BMI) Ð weight (kg)aheight (m 2 )), body fat distribution (de®ned by the abdominal ± thigh ratio (AaT)) and initial weight loss after medical treatment. Psychological evaluation was performed with the Minnesota Multiphasic Personality Inventory (MMPI). In the last 30 patients, the Edinburgh Inventory of Manual Preference (EIMP) and the corticotrophin-releasing hormone (CRH) test were also performed. RESULTS: Clinical characteristics de®ned a priori were independent variables as evaluated by contingency table analysis. Factorial analysis of variance (ANOVA) revealed a signi®cantly different MMPI pro®le, according to parental obesity, with posthoc signi®cantly higher scores on the hypochondriasis (Hs), paranoia (Pa), psychasthenia (Pt) and schizophrenia (Sc) scales in patients with obese parents. Obese patients presented signi®cantly higher dichotomized manual preference indexes in relation to overweight patients. Parental obesity, binge eating behaviour with purging, body fat distribution and the dichotomized manual preference index were independent signi®cant factors for the ACTH response in the CRH test, together explaining 41% of the response variability. Age of onset of obesity and the dichotomized manual preference index were independent and signi®cant factors for the cortisol response, together explaining 37% of its variability. A non-normal distribution was found for the ACTH response: high-and low-responders presented signi®cantly different MMPI pro®les, with high-responders presenting higher scores on all clinical scales except masculinityafemininity (Mf). CONCLUSION: Overweightaobese subjects with parental obesity present a distinctive personality pro®le and a higher ACTH response in the CRH test. Cerebral asymmetry may be a relevant factor for obesity development and is associated with the HPA reactivity. HPA reactivity is a sensitive index integrating clinical, psychological and neural asymmetric factors. International Journal of Obesity (2001) 25, 24 ± 32

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“…In addition to the well-known laterality effects on cognitive functions like attention, language, and spatial and arithmetic talents, dramatically illustrated in stroke clinical syndromes, there is now experimental evidence in animals and humans for a sidedness effect on HPA reactivity (Geschwind & Galaburda, 1985a, 1985b, 1985cKim et al, 1999;Wittling, 1990;Wittling & Pfluger, 1990) that could be the missing link for the reported associations of autoimmune disorders and handedness (Geschwind & Galaburda, 1985a, 1985b, 1985cKang et al, 1991;McManus et al, 1990;Wood and Cooper, 1990). Furthermore, brain asymmetry has been related to cerebrospinal fluid CRH and serum cortisol levels and also to affective style and some immune parameters (Davidson, 1998;Davidson et al, 1999;Kalin et al, 1998Kalin et al, , 2000.…”

Section: Introductionmentioning

confidence: 99%

Personality, Brain Asymmetry, and Neuroendocrine Reactivity in Two Immune-Mediated Disorders: A Preliminary Report

Martins

Alves

Trinca³

et al. 2002

Brain, Behavior, and Immunity

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Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine reactivity in patients with systemic lupus erythematosus (SLE) and chronic hepatitis C (CHC) we used the corticotropin releasing hormone (CRH) test, the Minnesota Multiphasic Personality Inventory (MMPI), and the Edinburgh Inventory of Manual Preference Inventory (EIMP). Compared to controls, the adrenocorticotrophic hormone (ACTH) response to CRH was reduced in CHC, while SLE presented reduced baseline dehydroepiandrosterone sulfate levels; higher neurotic scores were found in SLE and higher behavior deviant scores in CHC. Peak ACTH levels were a significant factor for the MMPI profile variability, while the manual preference score was a significant factor for the ACTH response. Personality and manual preference contribute to neuroendocrine abnormalities. Different behavioral and neuroimmunoendocrine models emerge for these disorders.

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Neuroendocrine hemisphere asymmetries: Salivary cortisol secretion during lateralized viewing of emotion-related and neutral films

Cited by 124 publications

References 36 publications

Hormonal Correlates of Hand Preference in Free-ranging Primates

Hormonal Correlates of Hand Preference in Free-ranging Primates

Psychoneuroendocrine characteristics of common obesity clinical subtypes

Personality, Brain Asymmetry, and Neuroendocrine Reactivity in Two Immune-Mediated Disorders: A Preliminary Report

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