2007
DOI: 10.1002/9780470513989.ch3
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Neuroendocrine Metabolism of Progesterone and Related Progestins

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Cited by 28 publications
(14 citation statements)
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“…THP is formed from P via two enzymatic conversions, with 5α-reductase and 3α-hydroxysteroid oxidoreductase (3α-HSD) (Compagnone and Mellon, 2000; Karavolas and Hodges, 1990; Mellon and Vaudry, 2001). This steroid can be produced in the adrenal gland, with release into the general circulation before puberty onset.…”
Section: 4 Puberty and Pubertal Hormonesmentioning
confidence: 99%
“…THP is formed from P via two enzymatic conversions, with 5α-reductase and 3α-hydroxysteroid oxidoreductase (3α-HSD) (Compagnone and Mellon, 2000; Karavolas and Hodges, 1990; Mellon and Vaudry, 2001). This steroid can be produced in the adrenal gland, with release into the general circulation before puberty onset.…”
Section: 4 Puberty and Pubertal Hormonesmentioning
confidence: 99%
“…Thus, the enzymes and mitochondrial transporters necessary for the synthesis of GABA A R-active pregnane steroids are expressed in the CNS. The synthesis of 5α3α-THPROG and 5α3α-THDOC from PROG and DOC respectively, requires two sequential reactions catalyzed by 5α-reductase and 3α-hydroxysteroid dehydrogenase (3α-HSD; Karavolas and Hodges, 1990; Figure 1). These key enzymes are expressed within the CNS in a region-specific manner and often, are co-localized (Agis-Balboa et al, 2006).…”
Section: The Influence Of “Local” Neurosteroids On Neuronal Inhibitiomentioning
confidence: 99%
“…Estrogens can increase the activity of the enzymatic pathway (5>-R)-3-hydroxysteroid-oxidoreductase, which converts progesterone into 5-dihydroprogesterone and AP, respectively. 8,25 It has been postulated that raloxifene, DT56a, and estradiol have a common receptor(s) and mechanism of action in the bone and vascular tissue. 15,26/28 Thus, the same mechanism of action, mediated by the ER(s), might be recruited for the modulation of AP content in the brain and serum.…”
Section: Discussionmentioning
confidence: 99%