2021
DOI: 10.1007/s00423-021-02256-z
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Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome

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Cited by 8 publications
(10 citation statements)
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“…Zhou et al 30 retrospectively analyzed 446 patients with biliary NEN from the SEER database and found that young patients and patients with NET or smaller tumor size had a significantly better prognosis. Another SEER database study also revealed that age, tumor stage, extension, and grade were associated with the outcomes 28 . Adjuvant therapy has also been associated with improved OS rates 9 .…”
Section: Discussionmentioning
confidence: 97%
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“…Zhou et al 30 retrospectively analyzed 446 patients with biliary NEN from the SEER database and found that young patients and patients with NET or smaller tumor size had a significantly better prognosis. Another SEER database study also revealed that age, tumor stage, extension, and grade were associated with the outcomes 28 . Adjuvant therapy has also been associated with improved OS rates 9 .…”
Section: Discussionmentioning
confidence: 97%
“…Ayabe et al 8 analyzed 300 patients from a large national database in America and revealed that the median OS time was 25 months. Gogna et al 28 studied 482 patients with gallbladder NEN from the SEER database and found that the mean survival time was 37.11 months. In addition to survival time, reports on survival rates vary widely.…”
Section: Discussionmentioning
confidence: 99%
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“…The prognosis of GB-NEC is very poor and the recurrence risk is very high. 5 Very few pure LCNEC have been reported in the literature with a median survival of 8 to 10 months, so it becomes very difficult to propose the best management plan. 3 , 7 Still, surgical resection improves overall survival and is the cornerstone in the management of GB-NEC.…”
Section: Discussionmentioning
confidence: 99%
“… 3 , 7 Still, surgical resection improves overall survival and is the cornerstone in the management of GB-NEC. 5 For neuroendocrine tumours of GB, cholecystectomy could be enough if detected in early stages (in situ and T1 tumours). 5 , 6 Extended cholecystectomy (including GB, adjacent liver segments IVB & V along with adequate lymphadenectomy) should be the first line of treatment in patients with advanced GB-NEC without distant metastasis.…”
Section: Discussionmentioning
confidence: 99%