Neuroendocrine neoplasms of the ovary: an analysis of clinicopathological characteristics and prognosis with a focus on histological grading

Huang, Wenmin; Bao, Yiting; Luo, Xukai; Yao, Liangqing; Yuan, Lei

doi:10.1007/s12020-022-03067-y

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…The prognostic factors for primary ovarian carcinoids have been proposed in several studies that mainly focused on the tumor stage 7,12,18 . However, unlike other NETs, the role of the Ki‐67 proliferative index in determining survival outcomes and tumor grading has rarely been evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic factors for primary ovarian carcinoids have been proposed in several studies that mainly focused on the tumor stage. 7 , 12 , 18 However, unlike other NETs, the role of the Ki‐67 proliferative index in determining survival outcomes and tumor grading has rarely been evaluated. In the NETs of the digestive system and lung, the Ki‐67 index has been a reliable predictor of biological behavior and survival outcomes, with a cutoff value of 2%–10%.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and survival outcomes in patients with primary ovarian carcinoid: A historical cohort study

Kong

Sun

Sui

et al. 2023

Acta Obstet Gynecol Scand

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Introduction: Primary ovarian carcinoids are extremely rare ovarian tumors, and there is limited data available on their clinical characteristics and survival outcomes. Material and methods:We conducted a historical cohort study of 56 patients to investigate their clinical characteristics. The overall survival, disease-specific survival, recurrence-free survival, and potential prognostic factors of these patients were also evaluated. Results:The median age of these patients was 42.0 years (range: 20-71). The average mass and carcinoid size was 7.3 and 0.4 cm, respectively. Elevated tumor marker levels and ascites were observed in 15 and 10 patients, respectively. In 98.2% of the patients, tumors were confined to the ovary, while only one had metastatic disease. Surgery was the mainstay therapy: 37.5% of the patients underwent unilateral

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and survival outcomes in patients with primary ovarian carcinoid: A historical cohort study

Kong

Sun

Sui

et al. 2023

Acta Obstet Gynecol Scand

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“…Primary ONTs are rare malignant neoplasms associated with unfavorable prognosis. There is limited data on the risk factors and prognosis compared to other pathological subtypes ( 24 - 26 ). LCNEC had the worst prognosis among ONTs in our study, with a 3-year DS rate of 21.8%.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and clinic-pathologic characteristics of ovarian tumor with different histologic subtypes—a SEER database population study of 41,376 cases

Shao,

Guo,

Chen

et al. 2023

Transl Cancer Res

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Background Ovarian cancer is considered the leading cause of cancer-related deaths among all gynecological malignancies and a significant reason for mortality in women. This cohort study aimed to explore the survival trends of malignant ovarian tumors (MOT), cancer antigen 125 (CA125) level, and clinicopathological prognostic factors of MOT by histological subtype. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, a total of 41,411 MOT cases diagnosed between January 2005 and December 2014 were extracted. According to the histological classification of MOT, four categories were included: epithelial ovarian carcinoma (EOC), malignant ovarian germ cell tumors (MOGCTs), malignant ovarian sex cord-stromal tumors (MOSCSTs) and ovarian neuroendocrine tumors (ONTs). We analyzed disease-specific survival (DS) and overall survival (OS) among the four categories, and their histological subtypes. Kaplan-Meier method was used to estimate survival curves, and log-rank test was used to evaluate differences between curves. Univariate and multivariate Cox proportional hazards models were applied to evaluate the prognostic impact of MOT. Results Significant predictors related to improved OS were younger age, low grade, early FIGO stage and localized SEER stage, while positive/elevated CA125 level was a risk factor. For MOGCT and MOSCST, 3-, 5- and 10-year DS rate estimates were all >80%, followed by ONT around 70%. Malignant epithelial cancer showed low DS rate at 3-year (70.7%), 5-year (58.7%), and 10-year (47.3%). Conclusions EOC patients had the worst outcome, whereas MOGCT cases had the most favorable survival. Positive/elevated CA125 level led to poor prognosis. Furthermore, younger age, low grade, early FIGO stage and localized SEER stage were significant predictors for improved OS.

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“…The present study refers to adjuvant therapies for lung small cell carcinoma, speci cally chemotherapy and radiation [2].…”

Section: Therapy Of Ovarian Neuroendocrine Carcinomamentioning

confidence: 99%

“…NENs are a heterogeneous group of diseases. Neuroendocrine carcinoma (NEC) of the ovary represents the highly malignant end of this spectrum, characterized by high-grade tumors that often exhibit aggressive clinical behavior and unfavorable outcomes [2]. NEC of the ovary can be further classi ed into two subtypes: large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma of the ovary (SCCO) [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

Xing,

Zhang,

Liu

et al. 2023

Preprint

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Background Neuroendocrine neoplasms (NENs) of the female genital tract are rare. This study aims to enhance our clinical understanding of neuroendocrine carcinoma of the ovary. Methods A retrospective review was conducted on 12 patients diagnosed with neuroendocrine carcinoma of the ovary, analyzing clinicopathological characteristics, treatment modalities, and survival status. Results The median age at diagnosis was 34.5 years (range: 20 to 62 years). Among the 12 cases, 9 were small cell carcinoma of the ovary (SCCO) and 3 were large cell neuroendocrine carcinoma (LCNEC). Five cases were stage I tumors, one case was stage IV, and six cases were stage III. Eleven patients underwent surgery as part of their treatment. All patients received adjuvant chemotherapy. Among the 12 patients, one patient received radiotherapy, and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after chemotherapy. The median progression-free survival was 13 months, and the median overall survival was 19.5 months. Four cases remained disease-free, while eight cases experienced tumor recurrence, including three cases that resulted in death due to disease recurrence. Conclusion Neuroendocrine carcinoma of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical outcomes. Surgical resection remains the mainstay of treatment, with some patients benefiting from adjuvant chemoradiation therapy.

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Neuroendocrine neoplasms of the ovary: an analysis of clinicopathological characteristics and prognosis with a focus on histological grading

Cited by 7 publications

References 13 publications

Clinical characteristics and survival outcomes in patients with primary ovarian carcinoid: A historical cohort study

Clinical characteristics and survival outcomes in patients with primary ovarian carcinoid: A historical cohort study

Prognostic factors and clinic-pathologic characteristics of ovarian tumor with different histologic subtypes—a SEER database population study of 41,376 cases

Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

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