Neuroendocrine tumors of stomach. Modern classification

Abstract

Neuroendocrine tumors (NETs) of the stomach include a wide range of neoplasm with different variants of the disease, various approaches to the treatment and different prognosis. The incidence is quite low - NETs of stomach accounted for only 9% of all gastrointestinal (GI) NETs and 0,3% of all tumors of stomach. Gastric NETs have significantly different biological and clinical characteristics from other carcinoids developing from “foregut”. The distinctive features of these tumors attract the attention of many scientists. Modern methods of instrumental diagnostics, as well as histological, immunohistochemical and molecular genetic, make it possible to assess malignant potential of the tumor and individualize treatment in every case. In this article we have tried to bring the information about NET with high and poor differentiation, which include small and large cell types together.