Neurofibroma of the hard palate

Cartwright, Bethany; Corsar, Kenneth

doi:10.1136/bcr-2020-239887

Cited by 2 publications

(3 citation statements)

References 6 publications

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Section: Discussionmentioning

confidence: 99%

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Guo,

Wu,

Liang

et al. 2024

Preprint

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Background Neurofibroma is a benign tumor of neuronal origin that can occur as a solitary tumor or as a component of the generalized syndrome of neurofibromatosis. Neurofibromas are primarily located in the subcutaneous soft tissues and commonly involve extra-oral sites. Solitary intraosseous neurofibromas of the oral cavity are infrequent, with occurrences in the maxilla being exceedingly rare. Case presentation: A 22-year-old male patient presented with an asymptomatic mass in the maxilla. Cone-beam computed tomography revealed a round, well-outlined, radiolucent lesion with expansive growth. The neoplasm with the complete capsule was completely removed and confirmed as a neurofibroma based on histopathological and immunohistochemical findings. The reported cases of solitary intraosseous neurofibromas located in the maxilla published in the English literature were compiled to assist in the diagnosis of solitary intraosseous neurofibromas of the maxilla. Four months after the surgery, there were no signs of tumor recurrence or malignant transformation. Conclusions This report emphasizes that rare neoplasms, such as solitary intraosseous neurofibromas, typically demonstrate nonspecific clinical and radiological features. Clinicians should consider solitary intraosseous neurofibromas as possible differential diagnoses and recognize the histopathological and immunohistochemical features to confirm the correct diagnosis. A longer follow-up period is required because of the potential for local recurrence and malignant transformation of these tumors.

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Section: Discussionmentioning

confidence: 99%

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Guo,

Wu,

Liang

et al. 2024

Preprint

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“…In the present case, the tumor was an isolated intraosseous entity that was not associated with any systemic pathology and seldom changed into a malignant form. However, it is important to consider that solitary intraosseous neurofibroma may be an initial manifestation of NF-1 [ 8 , 12 ] with no family history, but it can be caused by a spontaneous mutation [ 23 , 24 ]. There are no distinctive features between solitary and multiple forms apart from systemic and hereditary factors; if possible, genetic studies to rule out common autosomal genetic disorders are recommended [ 19 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical behavior of neurofibromas is characterized by a benign course with a low frequency of recurrence after surgical excision, primarily because of the absence of a complete capsule [2][3][4][5][6]23]. The local recurrence rate of this condition may be lower due to the appearance of an intact envelope.…”

Section: Discussionmentioning

confidence: 99%

Solitary intraosseous neurofibroma of the oral cavity: rare localization in the maxilla

Guo,

Wu,

Liang

et al. 2024

BMC Oral Health

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Background Neurofibroma is a common benign tumor of neuronal origin that can occur as a solitary tumor or as a component of the generalized syndrome of neurofibromatosis. Neurofibromas are primarily located in the subcutaneous soft tissues and commonly involve extra-oral sites. Solitary intraosseous neurofibromas of the oral cavity are infrequent, with occurrences in the maxilla being exceedingly rare. Case presentation A 22-year-old male patient presented with an asymptomatic mass in the maxilla. Cone-beam computed tomography revealed a round, well-outlined, radiolucent lesion with expansive growth. The neoplasm with the complete capsule was completely removed and confirmed as a neurofibroma based on histopathological and immunohistochemical findings. The reported cases of solitary intraosseous neurofibromas located in the maxilla published in the English literature were compiled to assist in the diagnosis of solitary intraosseous neurofibromas of the maxilla. Nine months after the surgery, there were no signs of tumor recurrence or malignant transformation. Conclusions This report emphasizes that rare locations of neurofibromas, such as solitary intraosseous neurofibromas in the maxilla, typically demonstrate nonspecific clinical and radiological features. Clinicians should consider solitary intraosseous neurofibromas as possible differential diagnoses and recognize the histopathological and immunohistochemical features to confirm the correct diagnosis. A longer follow-up period is required because of the potential for local recurrence and malignant transformation of these tumors.

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Neurofibroma of the hard palate

Cited by 2 publications

References 6 publications

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Solitary intraosseous neurofibroma of the oral cavity: rare localization in the maxilla

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