Neurofibromatosis with Intrahepatic, Retroperitoneal and Pelvic Involvement: A Case Report and Literature Review

Abstract

Neurofibromatosis type 1 (NF1) is a benign peripheral nerve sheath tumor, which can primarily cause neurocutaneous manifestations. We herein present a rare case of periportal neurofibromatosis with intrahepatic, retroperitoneal and pelvic involvement. The patient underwent abdominal ultrasound (US), magnetic resonance imaging, and a positron emission tomography-computed tomography. Despite these various imaging features, a diagnosis of lymphomas could not be entirely excluded. The patient therefore underwent US-guided biopsy, and a diagnosis of intrahepatic neurofibromatosis was made.Through retrospective analysis of this case along with literature review, we concluded that distributing along the Glisson's sheath may be a characteristic in the diagnosis of NF that involves liver.

Ultrasound-responsive matters for biomedical applications

“…Two-dimensional ultrasonography provides the anatomical structure of the human body, and the combination of both techniques provides complete anatomical information, contributing to the clinical evaluation of blood distribution, flow direction, and velocity. 8 , 9 In contrast, share-wave elastography is another emerging US imaging technique that manipulates the acoustic radiation force produced by an ultrasonic beam to perturb the tissue. 10 Elastic media such as human tissue respond to this push because of its own restorative force, thus causing mechanical waves that can be used to quantitatively display the hardness of human soft tissue.…”

“… 10 Elastic media such as human tissue respond to this push because of its own restorative force, thus causing mechanical waves that can be used to quantitatively display the hardness of human soft tissue. 9 Share-wave technology has been applied in medical imaging by medical engineers in recent years, offering a promising tool for tissue characterization. Typically, liquid containing bubbles has the characteristic of strong scattering properties of US, leading to the development of contrast-enhanced US (CEUS).…”