Neurofilament Protein and Neuronal Activity Markers Define Regional Architectonic Parcellation in the Mouse Visual Cortex

Gucht, Estel Van der; Hof, Patrick R.; Brussel, Leen Van; Burnat, Kalina; Arckens, Lutgarde

doi:10.1093/cercor/bhm012

Cited by 80 publications

(100 citation statements)

References 74 publications

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“…The manatee mainly exhibited light staining in layers IIIc and parts of VI, and heavy staining in layer V, while cetaceans have heavy staining in the combined layer IIIc/V . This pattern differs from what is seen in primates, rodents and carnivores, where staining is more diffusely distributed throughout the cortex wherever there are pyramidal neurons [Campbell and Morrison, 1989;Chaudhuri et al, 1996;Hof et al, 1996;Nimchinsky et al, 1997;Preuss et al, 1997;Budinger et al, 2000;Tsang et al, 2000;Van der Gucht et al, 2001;Sherwood et al, 2004;Baldauf, 2005;Boire et al, 2005;Bourne et al, 2005;Hof and Sherwood, 2005;Bourne et al, 2007;Van der Gucht et al, 2007] but is similar to what is also observed in afrotherians, xenarthrans, monotremes and marsupials Hassiotis et al, 2005;Sherwood et al, 2009]. Primates, rodents and carnivores also have different patterns of NPNFP-ir neuron distribution in different cortical areas [Campbell and Morrison, 1989;Campbell et al, 1991;Hof and Nimchinsky, 1992;Budinger et al, 2000;Van der Gucht et al, 2001, which is not as clearly variable across the cortex in afrotherians, xenarthrans, monotremes and marsupials Ashwell et al, 2005;Hassiotis and Paxinos, 2004;Hassiotis et al, 2005;Sherwood et al, 2009].…”

Section: Possible Factors Influencing Manatee Neuron Types and Districontrasting

confidence: 55%

Neuron Types in the Presumptive Primary Somatosensory Cortex of the Florida Manatee (Trichechus manatus latirostris)

Reyes

Stimpson²,

Gupta³

et al. 2015

Brain Behav Evol

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Within afrotherians, sirenians are unusual due to their aquatic lifestyle, large body size and relatively large lissencephalic brain. However, little is known about the neuron type distributions of the cerebral cortex in sirenians within the context of other afrotherians and aquatic mammals. The present study investigated two cortical regions, dorsolateral cortex area 1 (DL1) and cluster cortex area 2 (CL2), in the presumptive primary somatosensory cortex (S1) in Florida manatees (Trichechus manatus latirostris) to characterize cyto- and chemoarchitecture. The mean neuron density for both cortical regions was 35,617 neurons/mm³ and fell within the 95% prediction intervals relative to brain mass based on a reference group of afrotherians and xenarthrans. Densities of inhibitory interneuron subtypes labeled against calcium-binding proteins and neuropeptide Y were relatively low compared to afrotherians and xenarthrans and also formed a small percentage of the overall population of inhibitory interneurons as revealed by GAD67 immunoreactivity. Nonphosphorylated neurofilament protein-immunoreactive (NPNFP-ir) neurons comprised a mean of 60% of neurons in layer V across DL1 and CL2. DL1 contained a higher percentage of NPNFP-ir neurons than CL2, although CL2 had a higher variety of morphological types. The mean percentage of NPNFP-ir neurons in the two regions of the presumptive S1 were low compared to other afrotherians and xenarthrans but were within the 95% prediction intervals relative to brain mass, and their morphologies were comparable to those found in other afrotherians and xenarthrans. Although this specific pattern of neuron types and densities sets the manatee apart from other afrotherians and xenarthrans, the manatee isocortex does not appear to be explicitly adapted for an aquatic habitat. Many of the features that are shared between manatees and cetaceans are also shared with a diverse array of terrestrial mammals and likely represent highly conserved neural features. A comparative study across manatees and dugongs is necessary to determine whether these traits are specific to one or more of the manatee species, or can be generalized to all sirenians.

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Section: Possible Factors Influencing Manatee Neuron Types and Districontrasting

confidence: 55%

Neuron Types in the Presumptive Primary Somatosensory Cortex of the Florida Manatee (Trichechus manatus latirostris)

Reyes

Stimpson²,

Gupta³

et al. 2015

Brain Behav Evol

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“…Significance was set at p Ͻ 0.05. Diamond et al, 1999;Paxinos and Franklin, 2001;Grove and Fukuchi-Shimogori, 2003;Van der Gucht et al, 2007). Green shading is for primary somatosensory cortex (BF, barrel field; FL, forelimb; HL, hindlimb; LL, lower lip; No, nostril; Rv, rostral vibrissae; Tr, trunk; UL, upper lip), blue shading is for visual cortex and red shading for motor cortex.…”

Section: Methodsmentioning

confidence: 99%

Local Hemodynamics Dictate Long-Term Dendritic Plasticity in Peri-Infarct Cortex

Mostany¹,

Chowdhury²,

Johnston³

et al. 2010

J. Neurosci.

115

107

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Changes in dendritic spine turnover are a major mechanism of experience-dependent plasticity in the adult neocortex. Dendritic spine plasticity may also contribute to functional recovery after stroke, but in that setting its expression may be complicated by alterations in local tissue perfusion, especially around the infarct. Using adult Thy-1 GFP-M mice, we simultaneously recorded long-term spine dynamics in apical dendrites from layer 5 pyramidal cells and blood flow from surrounding capillaries with in vivo two-photon microscopy in peri-infarct cortex before and after unilateral middle cerebral artery occlusion. Blood flow in periinfarct cortex decreased significantly immediately after stroke and improved gradually over time, in a distance-dependent manner from the epicenter of the infarct. However, local tissue perfusion was never fully restored even after a 3 month recovery period. On average, surviving layer 5 pyramidal neurons experienced a ϳ20% decrease in spine density acutely after stroke but eventually recovered. The dynamics of this improvement were different depending on the degree of tissue perfusion acutely after arterial occlusion. Cells in ischemic areas closer to the infarct returned to normal spine density levels slowly by retaining spines, while cells in more remote regions with preserved blood flow recovered faster by adding more spines, eventually surpassing baseline spine density by 15%. Our data suggest that maintaining tissue perfusion in the area surrounding the infarct could hasten or augment synaptic plasticity and functional recovery after stroke.

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“…8 ; see list of abbreviations). Recent architectonic studies in the mouse have further divided this medial cortex into a V2M caudally and 4 rostromedial fields (RM1-4) using nonphosphorylated neurofilament protein [ Van der Gucht et al, 2007].…”

Section: Organization Of Visual Cortexmentioning

confidence: 99%

All Rodents Are Not the Same: A Modern Synthesis of Cortical Organization

Krubitzer

Campi²,

Cooke³

2011

Brain Behav Evol

128

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Rodents are a major order of mammals that is highly diverse in distribution and lifestyle. Five suborders, 34 families, and 2,277 species within this order occupy a number of different niches and vary along several lifestyle dimensions such as diel pattern (diurnal vs. nocturnal), terrain niche, and diet. For example, the terrain niche of rodents includes arboreal, aerial, terrestrial, semi-aquatic, burrowing, and rock dwelling. Not surprisingly, the behaviors associated with particular lifestyles are also highly variable and thus the neocortex, which generates these behaviors, has undergone corresponding alterations across species. Studies of cortical organization in species that vary along several dimensions such as terrain niche, diel pattern, and rearing conditions demonstrate that the size and number of cortical fields can be highly variable within this order. The internal organization of a cortical field also reflects lifestyle differences between species and exaggerates behaviorally relevant effectors such as vibrissae, teeth, or lips. Finally, at a cellular level, neuronal number and density varies for the same cortical field in different species and is even different for the same species reared in different conditions (laboratory vs. wild-caught). These very large differences across and within rodent species indicate that there is no generic rodent model. Rather, there are rodent models suited for specific questions regarding the development, function, and evolution of the neocortex.

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Neurofilament Protein and Neuronal Activity Markers Define Regional Architectonic Parcellation in the Mouse Visual Cortex

Cited by 80 publications

References 74 publications

Neuron Types in the Presumptive Primary Somatosensory Cortex of the Florida Manatee <b><i>(Trichechus manatus latirostris)</i></b>

Neuron Types in the Presumptive Primary Somatosensory Cortex of the Florida Manatee <b><i>(Trichechus manatus latirostris)</i></b>

Local Hemodynamics Dictate Long-Term Dendritic Plasticity in Peri-Infarct Cortex

All Rodents Are Not the Same: A Modern Synthesis of Cortical Organization

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