Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Fialová, L; Bartoš, Aleš; Švarcová, Jana

doi:10.5507/bp.2017.038

Cited by 13 publications

(5 citation statements)

References 48 publications

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“…Data were extracted from 38 studies (Sjögren et al, 2001; de Jong et al, 2007; Pijnenburg et al, 2007; Bjerke et al, 2011; Kester et al, 2012; Gaiottino et al, 2013; Landqvist Waldö et al, 2013; Skillbäck et al, 2013; Evered et al, 2016; Melah et al, 2016; Fialova et al, 2017; Howell et al, 2017; Jensen et al, 2017; Lista et al, 2017; Pereira et al, 2017; Weston et al, 2017, 2019; Zhou et al, 2017; Bettcher et al, 2018; Chatterjee et al, 2018; Fortea et al, 2018; Hampel et al, 2018; Lewczuk et al, 2018; Lin et al, 2018; Merluzzi et al, 2018; Olsson et al, 2018; Paterson et al, 2018; Sánchez-Valle et al, 2018; Steinacker et al, 2018; Vogt et al, 2018; Zerr et al, 2018; Ashton et al, 2019; Bos et al, 2019; Lleó et al, 2019; Marchegiani et al, 2019; Mattsson et al, 2019; Niikado et al, 2019) which were selected by following eligibility criteria (Figure 1). Except for 2 longitudinal studies all others were cross sectional in design.…”

Section: Resultsmentioning

confidence: 99%

Role of Neurofilament Light Chain as a Potential Biomarker for Alzheimer's Disease: A Correlative Meta-Analysis

Jin

Cao

Dai

2019

Front. Aging Neurosci.

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Neurofilament light (NFL) is a putative biomarker of neurodegeneration. This study evaluates the correlative association of NFL with Alzheimer's disease (AD) indices. Relevant studies were identified after a literature search in electronic databases and study selection was based on pre-determined eligibility criteria. Correlation coefficients between NFL levels and important AD indices reported by individual studies were pooled as z-scores. Meta-regression analyses were performed to evaluate the relationships between important covariates. Data from 38 studies (age 68.3 years [95% confidence interval (CI): 65.7, 70.9]; 54 % [95% CI: 50, 57] females) were used. Meta-analyses of correlation coefficients reported by the included studies showed that NFL levels in blood and cerebrospinal fluid (CSF) correlated well (r = 0.59 [95% CI: 0.45, 0.71]; p < 0.0001). NFL levels correlated with MMSE score (r = −0.345 [95% CI: −0.43, −0.25]; p = 0.0001), and age (r = 0.485 [95% CI: 0.35, 0.61]; p = 0.00001). CSF NFL levels correlated with total tau (t-tau; r = 0.39 [95% CI: 0.27, 0.50]; p = 0.0001), phosphorylated tau (p-tau; r = 0.34 [95% CI: 0.19, 0.47]; p = 0.00001), and neurogranin (r = 0.25 [95% CI: 0.12, 0.37]; p = 0.001) but not with beta amyloid (Aβ) (r = 0.00 [95%CI: −0.13, 0.12]; p = 0.937). In meta-regression, MMSE scores were associated inversely with blood NFL (metaregression coefficient (MC) −0.236 [95% CI:−0.40, −0.072; p = 0.008), and age (MC) −0.235 [−0.36, −0.11]; p = 0.001) and positively with CSF Aβ-42 (MC 0.017 [0.010, 0.023]; p = 0.00001). NFL has good correlations with t-tau, and p-tau in CSF and CSF NFL levels correlates well with blood NFL levels. These results show that NFL can be a useful biomarker for improving diagnosis and predicting prognosis in AD patients especially if age weighted.

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Section: Resultsmentioning

confidence: 99%

Role of Neurofilament Light Chain as a Potential Biomarker for Alzheimer's Disease: A Correlative Meta-Analysis

Jin

Cao

Dai

2019

Front. Aging Neurosci.

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“…Much of the research in cell impairment has examined that Aβ25–35 broke down cytoskeletons consisting of axon. Neurofilament, as the core of the axon, plays an important role in the formation of cell cytoskeletons [15]. Thus, based on this evidence, the expression of neurofilament protein and cellular morphology need to be measured to detect the role of hsa-miR-6845-3p in Aβ25–35 damaging model by confocal laser scanning microscopy.…”

Section: Resultsmentioning

confidence: 99%

The emerging role of microRNA-4487/6845-3p in Alzheimer’s disease pathologies is induced by Aβ25–35 triggered in SH-SY5Y cell

Zhang

Yuan

et al. 2018

BMC Syst Biol

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BackgroundAccumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer’s disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis of AD. However, regarding whether miRNA is involved in the accumulation of Aβ in AD, the underlying molecule mechanism remains unclear. Therefore, we conduct a systematic identification of the promising role of miRNAs in Aβ deposition, and shed light on the molecular mechanism of target miRNAs underlying SH-SY5Y cells treated with Aβ-induced cytotoxicity.ResultsStatistical analyses of microarray data revealed that 155 significantly upregulated and 50 significantly downregulated miRNAs were found on the basis of log2 | Fold Change | ≥ 0.585 and P < 0.05 filter condition through 2588 kinds of mature miRNA probe examined. PCR results show that the expression change trend of the selected six miRNAs (miR-6845-3p, miR-4487, miR-4534, miR-3622-3p, miR-1233-3p, miR-6760-5p) was consistent with the results of the gene chip. Notably, Aβ25–35 downregulated hsa-miR-4487 and upregulated hsa-miR-6845-3p in SH-SY5Y cell lines associated with Aβ-mediated pathophysiology. Increase of hsa-miR-4487 could inhibit cells apoptosis, and diminution of hsa-miR-6845-3p could attenuate axon damage mediated by Aβ25–35 in SH-SY5Y.ConclusionsTogether, these findings suggest that dysregulation of hsa-miR-4487 and hsa-miR-6845-3p contributed to the pathogenesis of AD associated with Aβ25–35 mediated by triggering cell apoptosis and synaptic dysfunction. It might be beneficial to understand the pathogenesis and development of clinical diagnosis and treatment of AD. Further, our well-designed validation studies will test the miRNAs signature as a prognostication tool associated with clinical outcomes in AD.

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“…25 In this article, we calculated the ratios between CSF neurocytoskeletal proteins, NfL/T-tau, and NfL/P-tau 181 . 33 The acceptable coefficient of variation (CV) between duplicates was less than 20%. When the results were under the minimum level of detection determined by the manufacturer, the low-detection limit value was considered in the statistical analysis.…”

Section: Neurobehavioral Assessments Hand Diagnosis and Categorizationmentioning

confidence: 99%

Neurocytoskeleton Proteins in Cerebrospinal Fluid of People With HIV-1 Subtypes B and C

Almeida

Ribeiro

Tang

et al. 2020

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background:The objective was to compare the effect of HIV-1C and HIV-1B subtypes on neurofilament light (NfL) cerebrospinal fluid (CSF) levels and ratios of NfL to tau proteins. Additional comparisons were performed between people with HIV (PWH), participants with Alzheimer disease (AD), and HIV-negative controls (HIV-). We also calculated the diagnostic characteristics of CSF NfL and its ratios in HIV-associated neurocognitive disorder (HAND) diagnosis.Methods: CSF NfL, T-tau, and P-tau 181 concentrations were measured using immunoassays in a total of 108 CSF samples, including PWH (n = 68), HIV-(n = 16), and participants with AD (n = 24). These proteins were compared between HIV-1B (n = 27) and HIV-1C (n = 26) using multiple linear regression adjusted for nadir CD4 and plasma viral load suppression. Comparisons between PWH, HIV-, and participants with AD were adjusted for gender and age.Results: CSF neurocytoskeleton proteins and their ratios were comparable in HIV-1B and HIV-1C. However, the HIV-1C group had a higher proportion of samples of CSF NfL above the reference value (n = 14, 53.85%) than the HIV-1B group (n = 8, 29.63%), P = 0.098. The values of CSF NfL were higher in the AD group [2578 (1864; 3500) pg/mL] than those in PWH [683 (500; 1197) pg/mL, P < 0.001] and control [660 (539; 802) pg/mL, P = 0.012] groups. The value of CSF NfL and its ratios for HAND diagnosis were poor. Conclusion:The effects of HIV-1B and HIV-1C on CSF NfL and tau ratios were comparable. The differences in CSF neurocytoskeleton proteins between PWH and individuals with AD suggested they might not share the same mechanisms of impairment. Further research is necessary to evaluate CSF NfL on the differential diagnoses of HAND with AD.

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Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Cited by 13 publications

References 48 publications

Role of Neurofilament Light Chain as a Potential Biomarker for Alzheimer's Disease: A Correlative Meta-Analysis

Role of Neurofilament Light Chain as a Potential Biomarker for Alzheimer's Disease: A Correlative Meta-Analysis

The emerging role of microRNA-4487/6845-3p in Alzheimer’s disease pathologies is induced by Aβ25–35 triggered in SH-SY5Y cell

Neurocytoskeleton Proteins in Cerebrospinal Fluid of People With HIV-1 Subtypes B and C

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