Neurogenic Modifications Induced by Substance P in an Organ Culture of Human Skin

Branchet-Gumila, M.C.; Boisnic, S; Charpentier, Y. Le; Nonotte, Isabelle; Montastier, C.; Breton, Lionel

doi:10.1159/000066245

Cited by 22 publications

(21 citation statements)

References 21 publications

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“…Moreover, in vivo studies using neurokinin-1 receptor knockout mice have demonstrated that NK1R agonists are involved in modulating neutrophil accumulation in the inflamed, but not normal cutaneous microvasculature (740). A similar result was observed in a tissue culture model of human skin in which SP induced a dose-dependent edema, vasodilation, and extravasation of lymphocytes and mast cells through the microvascular wall and the release of proinflammatory mediators IL-1 and TNF-␣ in vitro (113). SP may directly cause vasodilatation on vascular endothelial cells via NK1R (100).…”

Section: Tachykinins and Neurokinin Receptorssupporting

confidence: 53%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

556

521

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This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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Section: Tachykinins and Neurokinin Receptorssupporting

confidence: 53%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

556

521

View full text Add to dashboard Cite

show abstract

“…In previous works [1, 2]we effectively demonstrated the interest of using an ex vivo surviving skin model to evaluate neurogenic mediators. We observed a good correlation between the results obtained with this experimental model and those of patients with slight palmar erythema (70–86% of vessels were dilated with a mean surface lumen of 130–188 µm 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…Skin specimens were fixed in Bouin’s solution and embedded in paraffin. Thick sections of 5 µm were stained with hematoxylin and eosin to evaluate vasodilation, according to methods described previously [1, 2]. Furthermore we studied brain samples to further investigate the relationship between the importance of PE redness, type of tumor, size and growth.…”

Section: Methodsmentioning

confidence: 99%

Palmar Erythema: Cutaneous Marker of Neoplasms

Noble¹,

Boisnic

Branchet-Gumila

et al. 2002

Dermatology

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Background: Acral erythema on the palms is observed in several conditions. However, the relationship with malignant tumors has only been reported exceptionally. It should be noted that tumors produce angiogenic mediators. Objective: These mediators might promote palmar erythema (PE), and the aim of the present study was to investigate the vasodilation of palmar skin capillaries and angiogenesis, mainly with tumors of the central nervous system. Methods: In a prospective study of 107 patients affected by brain tumors, we assessed PE clinically and the rate of dilated vessels histologically. We also evaluated the mean surface of the lumen of capillaries on skin biopsies and brain tumors. Results: 6.5% of the patients had an important erythema and 18.5% had slight and/or localized PE. In the skin biopsies, the rate of dilated vessels and the mean surface of the lumen of capillaries were higher than in normal skin. Moreover, the intensity of palmar redness was related to the increase in these vascular changes in the histopathological slices of brain tumors. The intensity also depended on the type of tumor and on its growth. Conclusion: The results of the present study strongly suggest that acral erythema is associated with malignant tumors and that the intensity of erythema and the vascular changes of brain tumors are related, probably due to angiogenic factors.

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“…The two experimental models used in our study were based on inhibition of substance P‐induced inflammation and free radical release caused by ultraviolet B (UVB) irradiation, respectively. Substance P (SP), the main neuropeptide triggering inflammatory responses in the skin, induces a composite neurogenic inflammation process involving NK 1 receptors and histamine release from mast cells and leading to vasodilation, edema, and pro‐inflammatory mediator release . UVB, directly absorbed by DNA, causes molecular rearrangements forming specific photoproducts, the major type being cyclobutane pyrimidine dimers (CPDs) involving two adjacent pyrimidine nucleotides on the same strand of DNA.…”

Section: Introductionmentioning

confidence: 99%