Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA

Ethans, Karen; Casey, Alan; Bard, Robert J.; Namaka, Michael

doi:10.2147/dnnd.s40349

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…Spinal cord transection/injury models are commonly utilized to study DO, DESD, and other types of lower urinary tract (LUT) dysfunction after any injury to the spinal cord, just as traumatic, developmental, infectious, vascular, degenerative injuries, and so on (Ethans et al, 2014;Panicker, 2020). Typically, the SCI model could be achieved by complete transection at different levels of spinal cord in different animals, particularly cats (de Groat et al, 1990) and rats (Shaker et al, 2003;Behr-Roussel et al, 2011).…”

Section: Animal Models Of Neurogenic Overactive Bladdermentioning

confidence: 99%

“…The mechanism underlying MS-related OAB symptoms is mainly due to the DO induced by suprapontine lesions, with disruption or lack of descending inhibitory impulses from the brain to the spinal cord (Ethans et al, 2014). Many studies about urodynamics in MS cases have demonstrated detrusor hyperreflexia or hyporeflexia (Akkoç et al, 2016;Wang et al, 2016).…”

Section: Neurological Conditions With Overactive Bladder Symptoms Multiple Sclerosis and Related Neuroinflammatory Disordersmentioning

confidence: 99%

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Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

2021

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Overactive bladder (OAB) is a common debilitating condition characterized by urgency symptoms with detrimental effects on the quality of life and survival. The exact etiology of OAB is still enigmatic, and none of therapeutic approaches seems curative. OAB is generally regarded as a separate syndrome, whereas in clinic, OAB symptoms could be found in numerous diseases of other non-urogenital systems, particularly nervous system. The OAB symptoms in neurological diseases are often poorly recognized and inadequately treated. This review provided a comprehensive overview of recent findings related to the neurogenic OAB symptoms. Relevant neurological diseases could be mainly divided into seven kinds as follows: multiple sclerosis and related neuroinflammatory disorders, Parkinson’s diseases, multiple system atrophy, spinal cord injury, dementia, peripheral neuropathy, and others. Concurrently, we also summarized the hypothetical reasonings and available animal models to elucidate the underlying mechanism of neurogenic OAB symptoms. This review highlighted the close association between OAB symptoms and neurological diseases and expanded the current knowledge of pathophysiological basis of OAB. This may increase the awareness of urological complaints in neurological disorders and inspire robust therapies with better outcomes.

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Section: Animal Models Of Neurogenic Overactive Bladdermentioning

confidence: 99%

Section: Neurological Conditions With Overactive Bladder Symptoms Multiple Sclerosis and Related Neuroinflammatory Disordersmentioning

confidence: 99%

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

2021

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“…Overactive bladder syndrome (OAB) is defined by the International Continence Society (ICS) as urinary urgency, usually with urinary frequency and nocturia, with or without urgency urinary incontinence [1,2]. Ethans et al indicated that OAB can be further differentiated into cases having neurological causes (mostly multiple sclerosis) or as being idiopathic [3].…”

Section: Introductionmentioning

confidence: 99%

Functional Polymorphism in the ADRB3 Gene, Encoding the Beta-3 Adrenergic Receptor, and Response to Intra-Detrusor Injection of Botulinum Toxin-A in Women with Overactive Bladder

Ciećwież

Lewandowska

Boroń

et al. 2022

JCM

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Background: There are reports suggesting an association between the rs4994 polymorphism in the ADRB3 gene encoding the beta-3 adrenergic receptor and OAB risk in females. The injection of botulinum toxin-A into the bladder wall is recommended as a possible treatment for OAB patients in whom first-line therapies have failed. The aim of our study was to analyze the possible association between the ADRB3:rs4994 polymorphism and the patient-perceived response to a single intra-detrusor injection of botulinum toxin-A in Polish women with overactive bladder. Methods: The study group consisted of 115 consecutive female patients with OAB. The response to botulinum toxin-A was evaluated at three months after injection, as absolute or relative reductions in OAB symptoms or in scores from questionnaires ICIQ-OAB (parts A and B) and ICIQ-LUTS-QoL (parts A and B). ADRB3:rs4994 variants were identified by the sequencing of genomic DNA extracted from buccal swabs. Results: There were no statistically significant differences between ADRB3:rs4994 [T];[T] homozygotes and [T];[C]+[C];[C] subjects for absolute or relative reductions in symptoms or in scores from all four questionnaire parts at three months after the injection of botulinum toxin-A. Conclusions: Our results do not support the hypothesis that ADRB3:rs4994 polymorphism is associated with the response to the intra-detrusor injection of botulinum toxin-A in Polish females with overactive bladder.

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Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder

Ciećwież,

Lewandowska,

Szylińska

et al. 2024

Pharmacol. Rep

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Background Intra-detrusor injection of botulinum neurotoxin type A (BoNT/A) is recommended as a possible treatment for patients with overactive bladder (OAB) in whom first-line therapies have failed. The c.190T > C (rs4994) polymorphism in the gene encoding the beta-3 adrenergic receptor (ADRB3) has been suggested to be associated with predisposition to OAB or with response to OAB treatment via a cholinergic muscarinic receptor antagonist. This prospective study aimed to use a urodynamic parameter-based assessment of response, six months after a single intra-detrusor injection of BoNT/A in female OAB patients, to elucidate possible association with the ADRB3 polymorphism. Methods The study group consisted of 138 consecutive, Polish, adult, female OAB patients. Urodynamic parameters were recorded before injection of BoNT/A and at six months after administration. ADRB3:rs4994 variants were identified by the sequencing of genomic DNA extracted from buccal swabs. Results Apart from baseline, and relative, increase in Maximum Cystometric Capacity (MCC) six months after BoNT/A injection, no significant differences were found in urodynamic parameters between reference TT homozygotes and women with at least one C allele. Conclusions Our results do not exclude that ADRB3:rs4994 variants are associated with a positive urodynamic test-based response to intra-detrusor injection of BoNT/A in females with OAB.

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Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA

Cited by 5 publications

References 49 publications

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

Functional Polymorphism in the ADRB3 Gene, Encoding the Beta-3 Adrenergic Receptor, and Response to Intra-Detrusor Injection of Botulinum Toxin-A in Women with Overactive Bladder

Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder

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