2006
DOI: 10.1016/j.neulet.2006.09.027
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Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death

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Cited by 148 publications
(140 citation statements)
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“…Knockdown of Ngb rendered these cultures more vulnerable to hypoxia, whereas forced overexpression of Ngb in a cell line derived from hippocampal neurons conferred relative protection from hypoxia. In another study, cultured human neuroblastoma cells transfected with a Ngb-(or Cgb-) expressing plasmid were resistant to oxidative injury induced by H 2 O 2 (Fordel et al, 2006). In vivo studies yielded similar results.…”
Section: Introductionmentioning
confidence: 78%
“…Knockdown of Ngb rendered these cultures more vulnerable to hypoxia, whereas forced overexpression of Ngb in a cell line derived from hippocampal neurons conferred relative protection from hypoxia. In another study, cultured human neuroblastoma cells transfected with a Ngb-(or Cgb-) expressing plasmid were resistant to oxidative injury induced by H 2 O 2 (Fordel et al, 2006). In vivo studies yielded similar results.…”
Section: Introductionmentioning
confidence: 78%
“…Recent studies of neuronal cancer cells support the finding of the antioxidative stress effects of Cygb. 10,11 In addition to Cygb, recent studies reported that hemoglobin 28 and myoglobin 45 also scavenge radicals, which emphasizes a role for globin proteins as antioxidants. Collectively, these in vitro studies suggest a novel antioxidative role for globins in addition to their known conventional facilitation of oxygen transport, and support the finding that Cygb serves as a defensive mechanism against oxidative stress.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, Ngb-overexpressing transgenic mice are resistant to cerebral infarction from occlusion of the middle cerebral artery [10,11]. Ngb also reduces the toxicity of H 2 O 2 [5], paraquat [5] and β-amyloid [13] in vitro. However, the mechanisms that underlie neuroprotection by Ngb are unknown.…”
mentioning
confidence: 99%