Diabetes is a multifaceted metabolic illness. When it is a chronic ailment, it severely damages several organs, including the kidneys, heart, eyes, blood arteries, and nerves. This further leads to difficulties with the macro and microvascular systems. Although there are currently enough medications to manage diabetes, there is a significant danger and death rate associated with the disease. One of the biggest problems facing medical and healthcare professionals is the reported partial relief and ongoing pain of their patients. A parallel epidemic of complications from diabetes and prediabetes has been brought on by the global epidemics of these conditions.While the last ten years have seen a significant advancement in our knowledge of the intricacies of diabetic neuropathy, the unique processes behind neuropathy in type 1 and type 2 diabetes are still unknown. To effectively treat and prevent diabetic neuropathy, further research on the disease's pathophysiology will be essential. People with diabetic peripheral neuropathy (DPN) have a much lower quality of life when they have painful diabetic neuropathy. The development of tolerance is a constraint and the efficacy of currently available pharmaceutical medicines is restricted. We shall talk about an Investigation on Novel Combination for Diabetic Neuropathy in this paper.