“…However, the role of Nrgn is less clear in rodent models, as overexpression of Nrgn enhances spatial memory (Chaalal et al, 2014; Huang et al, 2006; Zhong et al, 2015). Controversially, recent studies have shown that elevated CSF Nrgn levels are associated with increased severity of cognitive decline (Hellwig et al, 2015; Janelidze et al, 2016; Kester et al, 2015; Portelius et al, 2015). Increased Nrgn phosphorylation has also been associated with memory impairments (Andrade et al, 2008; Kim et al, 2010; Severino et al, 2011).…”