Neurohistological study of the development of experimental epileptogenic cortical cobalt-gelatine foci in rats and their correlation with the onset of epileptic electrical activity

Decreased GAB A, Benzodiazepine, and Picrotoxinin Receptor Binding in Brains of Rats After Cobalt‐Induced Epilepsy

“…As PTZ has a half-life of elimination of 3.8 h in the rat (Vohland and Koransky, 1972), the convulsant may have disappeared from the animal at the time of tissue sampling. All the cobalt-implanted rats showed a decreased threshold to PTZ convulsions, and 40% of these animals had spontaneous contralateral manifestations of focal irritation in the brain, which agrees with the findings of Fischer et al (1968). It is possible that 16-19 days after implantation the cell structures present after the heavy destruction of neuronal and glial elements maintain the epileptic activity in the focal area.…”

“…In vitro, the TBPS, MUS, and FLU binding were unaffected by 10-9-10-6 M cobalt. (7) 13.5 2 17 (7) 119 i 14 (7) 140 i 26 ( 3.1 ( 3 ) 1,052 f 167 ( 3 Fischer et al (1968) reported that epileptic activity appears on the 8th day in the cobalt focus after cobalt implantation to rats. Very soon thereafter, the contralateral and homotropic MF starts to spike independently of the primary focus.…”

“…The animals have manifestations of epileptic activity such as contralateral jerks. Three weeks after implantation the histopathological changes have stabilized (Fischer et al, 1968), but the spiking activity continues up to the 30th day (Engel, 1968), possibly even longer.…”