Neurohumoral Cardiovascular Responses to Alcohol and Their Modulation by Peroral Fluid

Sehested, J.; Heringlake, Matthias; Schmidt, Volker

doi:10.1016/s0002-9149(97)01010-2

Cited by 18 publications

(18 citation statements)

References 25 publications

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“…Conversely, 2 of 12 studies including Murata and colleagues (1994) and Reed and colleagues (1999) reported only the loading dose of alcohol but not BAC (Table 2). Interestingly, in a study by Koskinen and colleagues (1994), the BAC reached only 18.9 mg/dl 60 minutes after consumption of an alcohol solution equivalent to 1 g/kg, while other studies utilizing an alcohol solution equivalent of 0.7 to 1 g/kg reported BACs between 83 and 114 mg/dl 60 minutes after alcohol consumption (van de Borne et al., 1997; Koskinen et al., 1994; Sehested et al., 1998; Weise et al., 1986).…”

Section: Resultsmentioning

confidence: 92%

“…Eight studies evaluated HRV response to acute alcohol consumption in healthy nonalcoholic volunteers (Gonzalez Gonzalez et al., 1992; Koskinen et al., 1994; Murata et al., 1994; Sehested et al., 1998; Spaak et al., 2010; van de Borne et al., 1997; Vaschillo et al., 2008; Weise et al., 1986). Low‐dose (0.3 g/kg) alcohol consumption (BAC = 30 mg/dl 60 minutes after consumption) resulted in increased LF, decreased HF and was interpreted as sympathetic activation and decreased parasympathetic input, respectively (Gonzalez Gonzalez et al., 1992).…”

Section: Resultsmentioning

confidence: 99%

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Changes in Heart Rate Variability Associated With Acute Alcohol Consumption: Current Knowledge and Implications for Practice and Research

Romanowicz¹,

Schmidt²,

Bostwick³

et al. 2011

Alcoholism Clin & Exp Res

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Alcohol consumption is associated with a broad array of physiologic and behavioral effects including changes in heart rate. However, the physiologic mechanisms of alcohol effects and the reasons for individual differences in the cardiac response remain unknown. Measuring changes in resting heart rate (measured as beats/min) has not been found to be as sensitive to alcohol's effects as changes in heart rate variability (HRV). HRV is defined as fluctuations in interbeat interval length which reflect the heart's response to extracardiac factors that affect heart rate. HRV allows simultaneous assessment of both sympathetic and parasympathetic activity and the interplay between them. Increased HRV has been associated with exercise and aerobic fitness, while decreased HRV has been associated with aging, chronic stress, and a wide variety of medical and psychiatric disorders. Decreased HRV has predictive value for mortality in general population samples and patients with myocardial infarction and used as an indicator of altered autonomic function. A significant inverse correlation was found between HRV and both the severity of depression and the duration of the depressive episode. HRV analysis provides insights into mechanisms of autonomic regulation and is extensively used to clarify relationships between depression and cardiovascular disease. This article will review the methodology of HRV measurements and contemporary knowledge about effects of acute alcohol consumption on HRV. Potential implications of this research include HRV response to alcohol that could serve as a marker for susceptibility to alcoholism. At present however there is almost no research data supporting this hypothesis.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Changes in Heart Rate Variability Associated With Acute Alcohol Consumption: Current Knowledge and Implications for Practice and Research

Romanowicz¹,

Schmidt²,

Bostwick³

et al. 2011

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…These effects are evident even after a 48-h abstinence in alcoholics (DePetrillo et al 1999). Likewise, acute alcohol ingestion in human and nonhuman primates is associated with disruptive autonomic effects, a decrease in HRV and elevated HR (Wang et al 1993;Rossinen et al 1997;Sehested et al 1998;Bennett et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis)

et al. 2007

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“…All studies are in agreement that acute alcohol ingestion results in a decrease in heart rate variability (HRV), as measured using frequency-domain or timedomain analyses (Newlin et al, 1990;Koskinen et al, 1994;Rossinen et al, 1997;Sehesterd et al, 1998). Although the effects of acute alcohol ingestion are presumed to be due to effects of alcohol on parasympathetic activity, the mechanism modulating these effects remains obscure.…”

mentioning

confidence: 55%

Effects of Alcohol Use and Gender on the Dynamics of EKG Time‐Series Data

DePetrillo

White

Liu

et al. 1999

Alcoholism Clin & Exp Res

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Hurst analysis of EKG data obtained from a population of alcoholic (n = 13) and nonalcoholic (n = 48) subjects was undertaken. Potential subjects (n = 120) were screened using the Schedule for Affective Disorders and Schizophrenia and Structured Clinical Interview for DSM-III instruments. Data from subjects with a diagnosis of current alcohol dependence were analyzed. Subjects with diagnoses such as major depression, bipolar disorder or schizophrenia (Axis I diagnoses), or personality disorders (Axis II diagnoses) were excluded from analysis. Subjects undergoing testing were free of alcohol and illicit drugs. Alcoholic subjects had no clinical evidence of alcohol withdrawal symptoms at the time of testing. EKG data were obtained with eyes open or with eyes closed. Approximately 3.5 min of data were obtained for each condition. Alcoholic subjects had less complex heart rate dynamics as evidenced by higher values of H = 0.18 +/- 0.05 (mean +/- SEM), compared with healthy comparison subjects with H = 0.09 +/- 0.02, p < 0.014 for the eyes closed condition, and H = 0.17 +/- 0.05 (mean +/- SEM) compared with healthy comparison subjects with H = 0.07 +/- 0.02,p < 0.011 for the eyes open condition. A gender effect was seen, with female subjects showing evidence of more complex heart rate dynamics than male subjects.

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Neurohumoral Cardiovascular Responses to Alcohol and Their Modulation by Peroral Fluid

Cited by 18 publications

References 25 publications

Changes in Heart Rate Variability Associated With Acute Alcohol Consumption: Current Knowledge and Implications for Practice and Research

Changes in Heart Rate Variability Associated With Acute Alcohol Consumption: Current Knowledge and Implications for Practice and Research

Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis)

Effects of Alcohol Use and Gender on the Dynamics of EKG Time‐Series Data

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