Neurohumoral regulation of spontaneous constrictions in suburothelial venules of the rat urinary bladder

Shimizu, Yuki; Mochizuki, Seibu; Mitsui, Retsu; Hashitani, Hikaru

doi:10.1016/j.vph.2014.01.002

Cited by 17 publications

(17 citation statements)

References 36 publications

(49 reference statements)

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“…13 In addition, calcitonin gene-related peptide (CGRP) nerve fibers, which regulate the immune system, were located in bladder smooth muscle and more densely distributed in the neck compared with the dome. 21 Recently, CGRP has shown to be associated with inflammation and venular relaxation. 21,22 Thus, we hypothesize that CGRP may play a role in CRBD.…”

Section: Discussionmentioning

confidence: 99%

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Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Bai

Wang

Liu

et al. 2015

Journal of Endourology

102

142

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Section: Discussionmentioning

confidence: 99%

“…21 Recently, CGRP has shown to be associated with inflammation and venular relaxation. 21,22 Thus, we hypothesize that CGRP may play a role in CRBD. Unfortunately, few literatures have reported on this issue.…”

Section: Discussionmentioning

confidence: 99%

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Bai

Wang

Liu

et al. 2015

Journal of Endourology

102

142

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“…We have recently demonstrated that the venules in the submucosal layer of the bladder [1][2][3], proximal antrum [4] and distal colon [5] develop spontaneous phasic constrictions, suggesting that the venules may more actively contribute to the regulation of the microcirculation than previously thought. Constrictions arise through contractions of venular SMCs or pericytes (depending on the vessel or vessel size) through spontaneous SR Ca 2+ release opening Ca 2+ -activated chloride channels, the resultant depolarization triggering the opening of L-type voltage-dependent Ca 2+ channels (VDCCs) and associated Ca 2+ influx [1,2,4,5].…”

Section: Introductionmentioning

confidence: 87%

Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum

et al. 2015

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Properties of spontaneous Ca(2+) transients in the myenteric microvasculature of the guinea-pig stomach were investigated. Specifically, we explored the spatio-temporal origin of Ca(2+) transients and the role of voltage-dependent Ca(2+) channels (VDCCs) in their intercellular synchrony using fluorescence Ca(2+) imaging and immunohistochemistry. The microvasculature generated spontaneous Ca(2+) transients that were independent of both Ca(2+) transients in interstitial cells of Cajal (ICC) and neural activity. Spontaneous Ca(2+) transients were highly synchronous along the length of microvasculature, and appeared to be initiated in pericytes and spread to arteriolar smooth muscle cells (SMCs). In most cases, the generation or synchrony of Ca(2+) transients was not affected by blockers of L-type VDCCs. In nifedipine-treated preparations, synchronous spontaneous Ca(2+) transients were readily blocked by Ni(2+), mibefradil or ML216, blockers for T-type VDCCs. These blockers also suppressed the known T-type VDCC dependent component of ICC Ca(2+) transients or slow waves. Spontaneous Ca(2+) transients were also suppressed by caffeine, tetracaine or cyclopiazonic acid (CPA). After the blockade of both L- and T-type VDCCs, asynchronous Ca(2+) transients were generated in pericytes on precapillary arterioles and/or capillaries but not in arteriolar SMCs, and were abolished by CPA or nominally Ca(2+) free solution. Together these data indicate that pericytes in the myenteric microvasculature may act as the origin of synchronous spontaneous Ca(2+) transients. Pericyte Ca(2+) transients arise from Ca(2+) release from the sarco-endoplasmic reticulum and the opening of T-type Ca(2+) VDCCs is required for their synchrony and propagation to arteriolar SMCs.

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“…Adenosine triphosphate (ATP) is released into the urinary space upon bladder stretch . Secretion of other molecules by the urothelium also may occur during filling‐emptying cycles, which may stabilize the filling process and improve vascular perfusion . In addition, the urothelium is sensitive to the excretion of drug metabolites and can affect other sensory functions .…”

Section: The Concept Of Urine Quality and Potential Effects On The Urmentioning

confidence: 99%

Urine: Waste product or biologically active tissue?

2018

Neurourology and Urodynamics

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Neurohumoral regulation of spontaneous constrictions in suburothelial venules of the rat urinary bladder

Cited by 17 publications

References 36 publications

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum

Urine: Waste product or biologically active tissue?

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