Neurohypophysial hormones in fetal life and pregnancy II. Chromatographic studies in the sheep (Ovis aries)

Vizsolyi, E.; Perks, A. M.

doi:10.1016/0016-6480(76)90005-8

Cited by 14 publications

(5 citation statements)

References 13 publications

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“…AVT-like bioactivity and/or immunoactivity have been reported in adult pineal glands of rats, mice, hamsters, guinea pigs, gerbils, and cows and in fetal bovine pineal glands [5,8,9,26]. Furthermore, there is good chemical evidence for AVT in fetal pituitaries provided by Vizsolyi and Perks [21] using amino acid analysis and in the bovine pineal gland by Cheesman and Farris using amino acid analysis and mass spectrometry [27,28]. Either a hypothalamic-pituitary or pineal source might account for the CSF AVT.…”

Section: Discussionmentioning

confidence: 85%

“…AVTlike bioactivity has been found in fetal neurohypophyses of several mam malian species, including sheep and seals [1,21], and AVT immunoreactivity has been reported in the neurohypophysis of the human and sheep fetus [2]. AVT-like bioactivity and/or immunoactivity have been reported in adult pineal glands of rats, mice, hamsters, guinea pigs, gerbils, and cows and in fetal bovine pineal glands [5,8,9,26].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in adult animals there is an orga nized diurnal rhythm of AVP and OT concentrations in CSF [14,15,17]. OT also has been measured in monkey and sheep amniotic fluid [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Radioimmunoassay of Vasotocin, Vasopressin, and Oxytocin in Human Neonatal Cerebrospinal and Amniotic Fluid

Artman¹,

Leake²,

Weitzman³

et al. 1984

Dev Pharmacol Ther

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Arginine vasotocin (AVT) has been measured in neonatal cerebrospinal fluid (CSF) and human amniotic fluid using a newly developed specific radioimmunoassay system. There were significant amounts of AVT in all samples. Vasopressin and oxytocin also were measured in the samples and could not account for the levels of vasotocin found. The source and function of these neurohypophyseal peptides in CSF and amniotic fluid remains speculative.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Radioimmunoassay of Vasotocin, Vasopressin, and Oxytocin in Human Neonatal Cerebrospinal and Amniotic Fluid

Artman¹,

Leake²,

Weitzman³

et al. 1984

Dev Pharmacol Ther

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“…Pavel [10,11] has reported both the in vitro bio synthesis of AVT bioactivity by human fetal neurohypophysial cells [10] and the presence of AVT bioactivity in newborn cerebrospinal fluid [11]. The presence of AVT in human fetal pituitaries was previously reported by RIA [12] and has now been confirmed by the use of RIA and HPLC analyses [3]. The role of AVT in the fetus and newborn is not known.…”

Section: Discussionmentioning

confidence: 89%

“…However, only 17% of the immuno reactivity (about 1 pg/ml) was actually at tributable to circulating AVT. AV I has been reported in pituitaries of fetal sheep by bioassay [12] and RIA [13], and AVT has been shown to be present in ovine fetal plasma and urine during the later stages of gestation [5]. The plasma levels in sheep dur ing the third trimester of gestation also are in the 1-to 2-pg/ml range [5].…”

Section: Discussionmentioning

confidence: 99%

Arginine Vasotocin and a Novel Oxytocin-Vasotocin-Like Material in Plasma of Human Newborns

et al. 1988

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Plasma of human adults contains an oxytocin, vasotocin-like (OT-VT) immunoreactive material that is estrogen responsive in both males and females and the levels of which are elevated during pregnancy. Although OT-VT is immunoreactive with an antiserum raised against synthetic arginine vasotocin (AVT), the elution profile of OT-VT by high-performance liquid chromatography (HPLC) is distinct from AVT, arginine vasopressin (AVP) or oxytocin (OT). Because the fetus is also exposed to high estrogen levels during pregnancy and AVT has been reported to be present in human fetal pituitaries, cord blood samples from 16 vaginally delivered human newborn infants were examined for evidence of OT-VT and AVT. Analysis of an extracted pool of cord blood plasma by HPLC revealed 4 peaks (I-IV) of AVT-like immunoreactivity. Peaks II and IV coeluted with synthetic AVP and OT, respectively, and were attributable to cross-reaction of the AVT antiserum with these peptides. Peak I was identified as AVT on the basis of its coelution with synthetic AVT. Peak III eluted in a manner identical with OT-VT. These results indicate that human newborn plasma contains at least three neurohypophysial peptides, AVP, OT and AVT. Additionally, newborn plasma contains an AVT-like immunoreactive material that is distinct from AVT, AVP and OT, but is identical with a novel OT-VT material observed in plasma of estrogen-primed adults. The physiological significance of AVT and OT-VT in newborn plasma remains to be determined.

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Hormonal Influences on Fetal and Perinatal Water Metabolism

Perks

Cassin

1987

Endocrinology and Physiology of Reproduction

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Neurohypophysial hormones in fetal life and pregnancy II. Chromatographic studies in the sheep (Ovis aries)

Cited by 14 publications

References 13 publications

Radioimmunoassay of Vasotocin, Vasopressin, and Oxytocin in Human Neonatal Cerebrospinal and Amniotic Fluid

Radioimmunoassay of Vasotocin, Vasopressin, and Oxytocin in Human Neonatal Cerebrospinal and Amniotic Fluid

Arginine Vasotocin and a Novel Oxytocin-Vasotocin-Like Material in Plasma of Human Newborns

Hormonal Influences on Fetal and Perinatal Water Metabolism

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