Neuroimagem e Biomarcadores no Prognóstico Funcional de Doentes com Acidente Vascular Cerebral

Branco, João; Costa, Joana Santos; Sargento-Freitas, João; Oliveira, Sandra de; Mendes, Bruno Coelho; Pinheiro, João Páscoa

doi:10.20344/amp.7411

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…De maneira geral, muitos estudos estão sendo conduzidos, mas eles ainda se mostram insuficientes para predizer a recuperação funcional, uma vez que um modelo de predição reprodutível e sensível não foi construído ou alcançado [24][25][26].…”

Section: Discussionunclassified

Biomarcadores relacionados à funcionalidade do membro superior de pessoas que sofreram acidente vascular cerebral: protocolo de revisão sistemática

Carrogi-Vianna,

Oliveira-Kumakura,

Garcia-Salazar

et al. 2024

Enferm Bras

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Objetivo: Determinar quais biomarcadores têm sido relacionados à funcionalidade do membro superior na fase aguda, subaguda ou crônica de pessoas que sofreram acidente vascular cerebral (AVC) isquêmico ou hemorrágico. Métodos: Protocolo de revisão sistemática, registrado no PROSPERO (CRD42021274244), com busca de dados sem corte de tempo na PubMed, PubMed PMC, Embase, Web of Science, Scopus, Cinahl e ProQuest. Os revisores avaliarão independentemente títulos, resumos e artigos de texto completo recuperados de bases de dados para identificar estudos potencialmente elegíveis. Os artigos relevantes serão avaliados quanto ao risco de viés e qualidade por meio do uso da ferramenta Quality In Prognosis Studies (QUIPS). A revisão incluirá estudos primários (original), do tipo Ensaios Controlados ou Observacionais (transversal, caso-controle ou estudos longitudinais) com análises de biomarcadores nas diferentes fases de AVC quanto à funcionalidade ou predição de recuperação. Serão excluídos pacientes com menos de 18 anos, diagnóstico de ataque isquêmico transitório e artigos que não explicitam os critérios de forma detalhada da avaliação dos biomarcadores. A qualidade e o risco de viés dos estudos serão avaliados de forma independente por dois pesquisadores. A síntese de dados será realizada utilizando um resumo narrativo e uma análise quantitativa. Modelos de meta-análise de efeitos aleatórios poderão ser empregados com base nas variáveis de resultados encontrados.

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Section: Discussionunclassified

Biomarcadores relacionados à funcionalidade do membro superior de pessoas que sofreram acidente vascular cerebral: protocolo de revisão sistemática

Carrogi-Vianna,

Oliveira-Kumakura,

Garcia-Salazar

et al. 2024

Enferm Bras

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“…As a consequence, the inclusion of lesion size in predictive models of outcome has the potential to improve stratification of samples and increase the power for effective detection in trials of acute therapies and of rehabilitative strategies in ischemic stroke. The evaluation of stroke volume and localization when combined with NIHSS showed potential predictive value, which might be further improved by several biomarkers, namely the S100 calcium-binding protein B, C-reactive protein, matrix metalloproteinases, and cerebral natriuretic peptide [34]. …”

Section: Structural Imagingmentioning

confidence: 99%

Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke

Heiss¹

2017

Cerebrovasc Dis

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Prediction measures of recovery and outcome after stroke perform with only modest levels of accuracy if based only on clinical data. Prediction scores can be improved by including morphologic imaging data, where size, location, and development of the ischemic lesion is best documented by magnetic resonance imaging. In addition to the primary lesion, the involvement of fiber tracts contributes to prognosis, and consequently the use of diffusion tensor imaging (DTI) to assess primary and secondary pathways improves the prediction of outcome and of therapeutic effects. The recovery of ischemic tissue and the progression of damage are dependent on the quality of blood supply. Therefore, the status of the supplying arteries and of the collateral flow is not only crucial for determining eligibility for acute interventions, but also has an impact on the potential to integrate areas surrounding the lesion that are not typically part of a functional network into the recovery process. The changes in these functional networks after a localized lesion are assessed by functional imaging methods, which additionally show altered pathways and activated secondary centers related to residual functions and demonstrate changes in activation patterns within these networks with improved performance. These strategies in some instances record activation in secondary centers of a network, for example, also in homolog contralateral areas, which might be inhibitory to the recovery of primary centers. Such findings might have therapeutic consequences, for example, image-guided inhibitory stimulation of these areas. In the future, a combination of morphological imaging including DTI of fiber tracts and activation studies during specific tasks might yield the best information on residual function, reserve capacity, and prospects for recovery after ischemic stroke.

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“…In recent years, the literature has shown that the presence of certain markers in the human body can directly influence stroke survivor prognoses, either positively or negatively. Even though some markers may act predictively, it is not yet known whether an individual marker -or a group of markers, for that matter -acting in isolation have absolute precision in patient prognoses [9]. In addition, these markers, which act as identification tools, are agents whose levels can be observed through experimental measurements that signal the presence of a pathological abnormality or disease in the organism, including a response to a particular pharmacological agent.…”

Section: Introductionmentioning

confidence: 99%

Can oxidative stress markers help define stroke prognosis?

2019

Biointerface Res Appl Chem

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Objective: To identify which oxidative stress markers can influence early stroke prognosis. Methodology: This is a systematic review carried out in two databases, PubMed and Web of Science, from November to December 2018. Two blinded, independent researchers probed the databases and gleaned descriptors indexed on both sites. "Markers", "oxidative stress" AND "stroke" were the terms singled out for this study. The inclusion criteria were: the articles needed to have been published in English from 2013 to 2018, as well as include descriptors either in the title or in the abstract, and involve clinical trials with samples composed of stroke survivors. The exclusion criteria were: research involving animal experimentation; duplicate publications; articles without a clear methodology; articles that chiefly addressed any disease other than stroke, and those that were not available in full. Results: This review identified TBARS, catalase, nitric oxide (NO), Thiois, C-reactive protein and SOD as the most recurrent oxidative regulation markers in stroke survivors. These findings may direct new research toward obtaining early prognoses, and therefore enable more accurate decision-making. thus minimizing the costs and time related to the patient rehabilitation process.

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Neuroimagem e Biomarcadores no Prognóstico Funcional de Doentes com Acidente Vascular Cerebral

Cited by 8 publications

References 13 publications

Biomarcadores relacionados à funcionalidade do membro superior de pessoas que sofreram acidente vascular cerebral: protocolo de revisão sistemática

Biomarcadores relacionados à funcionalidade do membro superior de pessoas que sofreram acidente vascular cerebral: protocolo de revisão sistemática

Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke

Can oxidative stress markers help define stroke prognosis?

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