Neuroimmunology and (Epi)Genetics in Depressive Disorders

Gałecki, Piotr; Bliźniewska-Kowalska, Katarzyna; Maes, Michaël; Su, Kuan‐Pin

doi:10.3390/jpm11070670

Cited by 2 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aetiology of depression is complex and multifactorial, including dysfunctions in the serotonergic system, changes in the functioning of the hypothalamic-pituitary-adrenal axis and issues in the field of immunology [22,31]. One of the approaches that aims to integrate the existing ones is the neurodevelopmental theory [4,21].…”

Section: Neurodevelopmental Theory Of Depressionmentioning

confidence: 99%

“…These results suggest that the observed dysregulation of HPA axis functioning is caused by the action of cytokines [29,30]. These interactions affect neuronal transmission and the functioning of the HPA axis [27], which results, among many other consequences, in a disruption of the kynurenine pathway [22,31]. The kynurenine hypothesis of the aetiology of depression indicates that inflammatory factors cause the excessive activation of indoleamine-2,3-dioxygenase.…”

mentioning

confidence: 92%

See 1 more Smart Citation

Inflammation and Cognition in Depression: A Narrative Review

Wachowska

Gałecki

2021

JCM

Self Cite

View full text Add to dashboard Cite

The authors aim to present a narrative review of research on the inflammatory aetiology of depression. Depression is a psychiatric disorder, constituting the most common reason of disability due to a health condition. It has been estimated that at least one in six people suffer from depression at some point of their lives. The aetiology of depression, although researched extensively all around the world, still remains unclear. Authors discuss the possible role of inflammation in depression, the neurodevelopmental theory of depression as well as associations between cognition and depression. Possible associations between memory dysfunction among depressive patients and inflammatory markers are included. The associations between the immune system, depression and cognition are observed. Possible mediating factors between these areas include personality traits, hormonal imbalance and functioning of the brain areas. The question as to what mediating factors are involved is still open to research.

show abstract

Section: Neurodevelopmental Theory Of Depressionmentioning

confidence: 99%

mentioning

confidence: 92%

Inflammation and Cognition in Depression: A Narrative Review

Wachowska

Gałecki

2021

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…The number of patients receiving antidepressant treatment is increasing every year [1]. However, only 60-70% of patients suffering from this disorder respond to the standard antidepressant treatment, which means that treatment-resistant depression (TRD) can be as prevalent as 1/3 of patients with clinical depression [3,4]. Hence, it is essential to continue searching for possible pathological mechanisms in order to find new, effective, and safe therapies.…”

Section: Introductionmentioning

confidence: 99%

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

Dziedzic,

Maciak,

Bliźniewska-Kowalska

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

The microbiota–gut–brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health and disease. Dysbiosis, a disturbance in the gut microbiome equilibrium, can significantly impact the MGB axis, leading to alterations in microbial composition and function. Emerging evidence highlights the connection between microbiota alterations and neurological and psychiatric disorders, including depression. This review explores the potential of psychobiotics in managing depressive disorders, emphasizing their role in restoring microbial balance and influencing the MGB axis. Psychobiotics exhibit positive effects on the intestinal barrier, immune response, cortisol levels, and the hypothalamic–pituitary–adrenal (HPA) axis. Studies suggest that probiotics may serve as an adjunct therapy for depression, especially in treatment-resistant cases. This review discusses key findings from studies on psychobiotics interventions, emphasizing their impact on the gut–brain axis and mental health. The increasing acceptance of the expanded concept of the MGB axis underscores the importance of microorganisms in mental well-being. As our understanding of the microbiome’s role in health and disease grows, probiotics emerge as promising agents for addressing mental health issues, providing new avenues for therapeutic interventions in depressive disorders.

show abstract

Neuroimmunology and (Epi)Genetics in Depressive Disorders

Abstract: Depression causes individual suffering, loss of productivity, increased health care costs and high suicide risk. Despite the fact that depressive disorders are a serious brain dysfunction, their etiopathogenesis is not yet fully understood [...]

Cited by 2 publications

References 10 publications

Inflammation and Cognition in Depression: A Narrative Review

Inflammation and Cognition in Depression: A Narrative Review

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

Contact Info

Product

Resources

About