Neuroimmunomodulation by estrogen in health and disease

Priyanka, Hannah P.; Nair, Rahul S.

doi:10.3934/neuroscience.2020025

Cited by 14 publications

(4 citation statements)

References 119 publications

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“…Increase oxidative stress in patients with breast cancer causes activation of the number of transcription factors and then lead to expression of the genes that include growth factor, inflammatory cytokines, chemokines and cell cycle regulatory molecules, 48 and then result in harm to DNA and impede signal transduction pathways responsible for cell proliferation, apoptosis, and angiogenesis. 49…”

Section: Discussionmentioning

confidence: 99%

Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients

Mahmood

Allwsh

2022

J. Contemp. Med. Sci.

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Objective: This study aimed to estimate the levels of HER2, PD-L1 and oxidative stress in newly diagnosed breast cancer patients. Also, to estimate the probability of using HER2 and PD-L1 as a predictive marker on the occurrence of breast cancer in addition to study the effect of menopausal status at the level of HER2, PD-L1, oxidative stress and breast cancer risk factor. Methods: This study included 125 newly diagnosed breast cancer patients (53 premenopausal and 72 postmenopausal) from Oncology and Nuclear Medicine Hospital in Mosul, Iraq, and 100 apparently healthy women as a control group (44 premenopausal and 56 postmenopausal), during the period from Jan. 2021 to Jun. 2021. The ages of patients and control are matched, and it is ranged from 30-60 years. In this study we estimate the level of Human Epidermal Growth Factor Receptor 2 (HER2), Programmed Death -Ligand 1(PD-L1), total antioxidant capacity (T-AOC), arylesterase activity, uric acid level, malondialdehyde (MDA) level, peroxidase activity, lactoperoxidase activity and iron level at breast cancer patients and control. Results: The results show that there is a significant elevation in the level of HER2, PD-L1, malondialdehyde, peroxidase, lactoperoxidase and iron, and a significant decrease in the level of T-AOC, arylesterase and uric acid in the serum of breast cancer patients (pre and postmenopausal) compared with the control group (pre and postmenopausal). Also, increase the level of HER2 and oxidative stress at postmenopausal status for the control and patient groups. while PD-L1 level does not affect by menopausal status for both control and patient groups. Conclusion: The level of HER2, PD-L1, and oxidative stress was significantly increased in newly diagnosed breast cancer patients compared with the control group at the same menopausal status. Increase breast cancer risk factor at the postmenopausal status.

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Section: Discussionmentioning

confidence: 99%

Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients

Mahmood

Allwsh

2022

J. Contemp. Med. Sci.

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“…Neuroimmunomodulation and its contribution to neurodegeneration has been vastly studied [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Maintaining a healthy interaction between neurons and the astrocytes, microglia, infiltrating monocytes, and other cells that initiate and modulate neuroimmune response is of great importance for neuronal health.…”

Section: Discussionmentioning

confidence: 99%

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

2021

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Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identification of numerous mutations either directly linked or associated with HSP and PLS begins to reveal the genetic component of UMN diseases. Since each of these mutations are identified on genes that code for a protein, and because cellular functions mostly depend on protein-protein interactions, we hypothesized that the mutations detected in patients and the alterations in protein interaction domains would hold the key to unravel the underlying causes of their vulnerability. In an effort to bring a mechanistic insight, we utilized computational analyses to identify interaction partners of proteins and developed the protein-protein interaction landscape with respect to HSP and PLS. Protein-protein interaction domains, upstream regulators and canonical pathways begin to highlight key cellular events. Here we report that proteins involved in maintaining lipid homeostasis and cytoarchitectural dynamics and their interactions are of great importance for UMN health and stability. Their perturbation may result in neuronal vulnerability, and thus maintaining their balance could offer therapeutic interventions.

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“…The intricate and complex interactions among these systems form a multidimensional network maintaining homeostasis and improving body function [ 62 ]. Estrogen affects the regulatory functions of the N-E-IN through a variety of ways [ 63 ]. The serotonin molecule is a classic neuroendocrine hormone.…”

Section: Role Of the Kidney/hpg Axis In The Maintenance Of Bone Funct...mentioning

confidence: 99%

Biological Deciphering of the “Kidney Governing Bones” Theory in Traditional Chinese Medicine

Zhu

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The description of the “kidney” was entirely different from modern medicine. In traditional Chinese medicine (TCM), the kidney was a functional concept regulating water metabolism, which was closely related to the urinary system, reproductive system, nervous system, endocrine, skeleton, hearing, metabolism, immunity, etc. In particular, the kidney in TCM plays an important regulatory role in the processes of growth, development, prime, aging, and reproduction. Hence, “Kidney Governing Bone” (KGB) was a classical theory in TCM, which hypothesized that the function of the kidney was responsible for bone health. However, the related modern physiological mechanisms of this TCM theory are unclear. This present paper proposed a new understanding and explored the biological basis of the KGB theory. After searching through plenty of reported literature, we discovered that the functions of the kidney in TCM were closely associated with the hypothalamic-pituitary-gonadal (HPG) axis in modern science. The physiological mechanism of the KGB was regulated by sex hormones and their receptors. This review deciphered the connotation of the KGB theory in modern medicine and further verified the scientificity of the basic TCM theory.

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Neuroimmunomodulation by estrogen in health and disease

Cited by 14 publications

References 119 publications

Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients

Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Biological Deciphering of the “Kidney Governing Bones” Theory in Traditional Chinese Medicine

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