Neuroimmunomodulatory compound for sensitive skin care: <i> in vitro</i> and clinical assessment

Dieamant, Gustavo de Campos; Pereda, Maria Del Carmen Velazquez; Eberlin, Samara; Nogueira, Cecília; Werka, Rejane Maria; Queiroz, Mary Luci de Souza

doi:10.1111/j.1473-2165.2008.00373.x

Cited by 31 publications

(35 citation statements)

References 22 publications

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“…Individuals with sensitive skin frequently report reddening of their skin [15,35,37,38,43,44,49,57,58]. Therefore, the assessment of erythema in skin irritation has been widely investigated, either by visual assessment [28,37,41,59,60] or by quantitative methods such as tristimulus reflectance colorimetry (a* value) [20,50,51,52], reflectance spectrophotometry (erythema index) [38,53,59] or laser Doppler flowmetry (cutaneous blood flow) [20,41,48,50,51,53,61].…”

Section: Resultsmentioning

confidence: 99%

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Richters

Falcone

Uzunbajakava³

et al. 2014

Skin Pharmacol Physiol

148

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Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701 articles which we appraised in detail. Impaired skin barrier function and increased vascular reactivity are most often associated with sensitive skin. We identified key reasons causing an ambiguity around the sensitive skin phenomenon. We propose using standardized selection methods of subjects by a multifactorial questionnaire spanning a range of provocations, including those of chemical, mechanical and environmental origin, followed by clinical, histological and top-notch biophysical measurements. This could lead to a breakthrough in the understanding of the sensitive skin phenomenon, fueling advances of biomedical and dermatological science. © 2014 S. Karger AG, Basel

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Section: Resultsmentioning

confidence: 99%

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Richters

Falcone

Uzunbajakava³

et al. 2014

Skin Pharmacol Physiol

148

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“…Rhodiola rosea B16F0 cells 1 Suppressed melanin synthesis and tyrosinase activity 2 Inhibited TRP-1 and tyrosinase expression 3 Inhibited MC1R/ CREB/ GSK3b/MITF [74,75] Rhodiola rosea extract/ L-carnosine-associated compound Human skin 1 Reduced transepidermal water loss (TEWL) 2 Elevated the skin barrier function 3 Positive subjective response [65] Rhodiola rosea extract/ L-carnosine-associated compound Keratinocytes 1 Promoted the release of proopiomelanocortin peptides 2 Restored to normal the increased levels of neuropeptides and cytokines [65] Rhodiola imbricata SD rats 1 Promoted wound healing 2 Promoted cellular proliferation 3 Increased collagen synthesis 4 Increased the DNA, protein, hydroxyprolin, and hexosamine in granulation cells 5 Antioxidant and decrease lipid peroxidation [38] Rhodiola crenulata extract Propionibacterium acnes antibiofilm activity against Propionibacterium acnes [66] Salidroside B16F0 cells Suppressed melanin synthesis and tyrosinase activity, but no effect on the expression of MC1R, MITF, TRP-1, or TRP-2 [74,78,79] Tyrosol B16F0 cells 1 Suppression of melanin synthesis and tyrosinase activity 2 Suppressed the expression of MC1R and TRP-1, but not TRP-2 and MITF [78] j o u r n a l o f f o o d a n d d r u g a n a l y s i s x x x ( 2 0 1 5 ) 1 e1 1 inhibition of HIF-1a [52]. Rhodiola sachalinensis and salidroside protected liver tissue from oxidative-stress-induced damage.…”

Section: Plants/constituents Models Results Referencesmentioning

confidence: 99%

Rhodiola plants: Chemistry and biological activity

Chiang

Chen

et al. 2015

Journal of Food and Drug Analysis

158

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Rhodiola is a genus of medicinal plants that originated in Asia and Europe and are used traditionally as adaptogens, antidepressants, and anti-inflammatory remedies. Rhodiola plants are rich in polyphenols, and salidroside and tyrosol are the primary bioactive marker compounds in the standardized extracts of Rhodiola rosea. This review article summarizes the bioactivities, including adaptogenic, antifatigue, antidepressant, antioxidant, anti-inflammatory, antinoception, and anticancer activities, and the modulation of immune function of Rhodiola plants and its two constituents, as well as their potential to prevent cardiovascular, neuronal, liver, and skin disorders.

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“…To quantify this subjective data, we utilized a 0–3 grade scale to evaluate the sensations after 0.17 min, and then every minute up to 5 min post-application of test materials. We supposed this scale could better quantify small changes in subjective responses (333435). …”

Section: Discussionmentioning

confidence: 99%

Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans

et al. 2016

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Sensitive skin is a frequently mentioned cosmetic complaint. Addition of a biomimetic of neuromediator has recently appeared as a promising new way to cure skin care product problems. This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protective effect with that of the well-known anti irritant strontium chloride. The effect of each test compound was studied on 28 selected healthy volunteers with sensitive skin in accordance with a double-blind vehicle-controlled protocol. From day 1 to day 13 each group was applied the test compound (bPOMC or strontium chloride) to one wing of the nose and the corresponding placebo (vehicle) to the other side twice daily. On days 0 and 14, acute skin irritation was induced by capsaicin solution and quantified using clinical stinging test assessments. Following the application of capsaicin solution, sensory irritation was evaluated using a 4-point numeric scale. The sensations perceived before and after treatment (on days 0 and 14) was calculated for the two zones (test materials and vehicle). Ultimately the percentage of variation between each sample and the placebo and also the inhibitory effect of bPOMC compared to that of strontium chloride were reported. Clinical results showed that after two weeks treatment, the levels of skin comfort reported in the group treated with bPOMC were significantly higher than those obtained in the placebo group and the inhibitory effect of bPOMC was about 47% higher than that of strontium chloride. The results of the present study support the hypothesis that biomimetic peptides may be effective on sensitive skin.

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Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment

Cited by 31 publications

References 22 publications

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Rhodiola plants: Chemistry and biological activity

Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans

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