Neuroleptiques Et Effets Extra-Pyramidaux: Correlation Entre Les Proprietes Antipsychotiques Et Extra-Pyramidales

Abstract

Data obtained in two comparative controlled studies of neuroleptics were used to ascertain if there were some correlation between the degree of improvement in the mental state and the severity of extrapyramidal symptoms induced in patients receiving one or other of the following neuroleptics: trifluperidol, trifluoperazine, T.P.S.-23 and chlorpromazine. In this study patients are used as experimental units. For each trial, the importance of psychiatric symptoms has been measured with the Brief Psychiatric Rating Scale and the neurological syndrome with the “Bilan extra-pyramidal” (Extrapyramidal Rating Scale). It has been impossible to find a correlation between the antipsychotic and extrapyramidal-inducing properties of the neuroleptics we have studied.