Neurological and Ocular Fascioliasis in Humans

Mas‐Coma, Santiago; Agramunt, Veronica H.; Valero, M. Adela

doi:10.1016/b978-0-12-800099-1.00002-8

Cited by 109 publications

(113 citation statements)

References 202 publications

(347 reference statements)

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“…This disease has recently proven to have a great morbidity impact throughout the biliary or chronic period of the disease (Valero et al 2003(Valero et al , 2006aGirones et al 2007), and not only due to the pathogenicity of the acute phase as hitherto believed (Chen and Mott, 1990). Clinical studies have shown this disease to be pronouncedly complex, giving rise to progressive general deterioration of the patients, with sequelae sometimes *Corresponding author: Madela.Valero@uv.es Syed Ali Ahasan et al 268 leaving them handicapped and frail, even including fatal cases (Mas-Coma et al 2014a). The diagnosis of the liver fluke infection in humans poses, moreover, many problems related to the different epidemiological scenarios and transmission patterns, as well as to the different situations in individual patients and due to the different periods this disease shows in humans Mas-Coma et al 2014b).…”

Section: Introductionmentioning

confidence: 99%

CIAS detection of Fasciola hepatica/F. gigantica intermediate forms in bovines from Bangladesh

Ahasan¹,

Valero

Chowdhury

et al. 2016

Acta Parasitologica

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Fascioliasis is an important food-borne parasitic zoonosis caused by two trematode species, Fasciola hepatica and Fasciola gigantica. The characterisation and differentiation of Fasciola populations is crucial to control the disease, given the different transmission, epidemiology and pathology characteristics of the two species. Lineal biometric features of adult liver flukes infecting livestock have been studied to characterise and discriminate fasciolids from Bangladesh. An accurate analysis was conducted to phenotypically discriminate between fasciolids from naturally infected bovines (cattle, buffaloes) throughout the country. Morphometric analyses were made with a computer image analysis system (CIAS) applied on the basis of standardised measurements and the logistic model of the body growth and development of fasciolids in the different host groups. Since it is the first ever comprehensive study of this kind undertaken in Bangladesh, the results are compared to pure fasciolid populations of F. hepatica from the European Mediterranean area and F. gigantica from Burkina Faso, geographical areas where both species do not co-exist. Principal component analysis showed that the biometric characteristics of fasciolids from Bangladesh are situated between F. hepatica and F. gigantica standard populations, indicating the presence of phenotypes of intermediate forms in Bangladesh. These results are analysed by considering the present emergence of animal fascioliasis, the local lymnaeid fauna, the impact of climate change, and the risk of human infection in the country.

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Section: Introductionmentioning

confidence: 99%

CIAS detection of Fasciola hepatica/F. gigantica intermediate forms in bovines from Bangladesh

Ahasan¹,

Valero

Chowdhury

et al. 2016

Acta Parasitologica

Self Cite

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“…After reaching the bile ducts, the helminth develops and transforms into a mature worm within three months [11]. Fever, abdominal pain, gastrointestinal disturbances, urticaria, and respiratory symptoms are among the major symptoms [6]. In their study, Ulger et al reported that 95% of patients had abdominal pain, and 79% of them had eosinophilia [17].…”

Section: Discussionmentioning

confidence: 99%

“…In the chronic phase, cholangitis and cholecystitis were the results of inflammation, epithelial hyperplasia, and thickening and dilatation of the bile ducts and gallbladder walls [6]. In patients admitted in the biliary phase, abdominal pain, pain in the upper right quadrant, biliary colic, jaundice associated with the obstruction of bile ducts by the adult parasite, and inflammatory response were the most common complaints [18].…”

Section: Discussionmentioning

confidence: 99%

“…An estimated 2.4 to 17 million people are infected in more than 51 countries [4]; 91 million are at risk worldwide [5]. This disease in humans shows an increasing importance, which is due to its recent widespread emergence related to climate and global changes and also its pathogenicity in the invasive, biliary, and advanced chronic phases in the human endemic areas, mainly of developing countries [6].…”

Section: Introductionmentioning

confidence: 99%

“…However, this method is complex and not reliable [1,7]. Computerized tomography findings are used in the diagnosis of fascioliasis in patients in the acute (invasive) phase, and ultrasonography findings are used in patients in the biliary phase [6,8]. The diagnosis has to be confirmed, which depends on serological findings and parasite tests [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey

Boşnak

Karaoğlan

Şahin

et al. 2016

J Infect Dev Ctries

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Introduction: In this study, clinical, laboratory, radiological, and serological examinations of fascioliasis patients were analyzed, and data with a significant impact on differential diagnosis were evaluated. Methodology: Clinical, radiological, and laboratory findings and treatment responses of a total of 22 fascioliasis patients, treated between October 2009 and September 2014, were evaluated. Nineteen patients were diagnosed with fascioliasis at the invasive phase and three patients at the chronic phase. Patients were followed up for clinical, laboratory, and radiology findings for a period of three months to one year after treatment. Results: The most frequent complaints in both groups were abdominal pain, and the most common physical examination finding was epigastric tenderness. In the performed examination, an eosinophil elevation in whole blood count was detected in 19 patients (100%) in the hepatic phase, and in 2 patients (66.6%) in the biliary phase. The results of the Fasciola hepatica indirect hemagglutination assay (IHA) test ordered in the diagnosis were positive in all patients. Treatment with 10 mg/kg/day triclabendazole for two consecutive days was effective. Live parasites were extracted from patients in the biliary phase with endoscopic retrograde cholangiopancreatography. In the follow-ups, remission in IHA titer and clinical and radiological improvement was achieved in all patients. Conclusions: If hypereosinophilia is detected by peripheral smear in patients who are admitted with complaints such as abdominal pain, weakness, nausea, myalgia, and weight loss, radiological evaluation and serological tests should be performed and fascioliasis should be considered in the differential diagnosis.

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